GHS Classification Result
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
Reference：
Chemical Name：1,1,2,2-Tetrachloro-1,2-difluoroethane (synonym: CFC-112)
CAS：76-12-0
Result：
| ID: | 837 |
| Classifier: | Inter-ministerial Committee on GHS |
| Year Classified: | FY2006 |
| Reference Manual: | GHS Classification Manual （10 Feb, 2006） |
PHYSICAL HAZARDS
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable | - | - | - | - | There are no chemical groups associated with explosive properties present in the molecules. |
| 2 | Flammable gases （including chemically unstable gases） | Not applicable | - | - | - | - | Solid (GHS definition) |
| 3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products |
| 4 | Oxidizing gases | Not applicable | - | - | - | - | Solid (GHS definition) |
| 5 | Gases under pressure | Not applicable | - | - | - | - | Solid (GHS definition) |
| 6 | Flammable liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
| 7 | Flammable solids | Not classified | - | - | - | - | Non-combustible |
| 8 | Self-reactive substances and mixtures | Not applicable | - | - | - | - | There are no chemical groups associated with explosive or self-reactive properties present in the molecule. |
| 9 | Pyrophoric liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
| 10 | Pyrophoric solids | Not classified | - | - | - | - | Non-combustible solids |
| 11 | Self-heating substances and mixtures | Not classified | - | - | - | - | Not combustible |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | - | The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
| 13 | Oxidizing liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
| 14 | Oxidizing solids | Not applicable | - | - | - | - | Organic compounds containing oxygen (but not chlorine and fluorine) and the oxygen is chemically bonded only to carbon (but not to other elements). |
| 15 | Organic peroxides | Not applicable | - | - | - | - | Organic compounds containing no -0-0- structure |
| 16 | Corrosive to metals | Classification not possible | - | - | - | - | No data available on corrosion to metals |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Not classified | - | - | - | - | In test using rats, mortality is not seen in 25g/kg (EHC113(1990) PATTY (5th, 2001)). Since this value was over the value of 5000mg/kg (oral: 2000mg/kg (Category 4) *2.5), it was set to outside of Category. |
| 1 | Acute toxicity （Dermal） | Not classified | - | - | - | - | In rabbit test, death is not observed at 7.5g/kg(PATTY (5th, 2001)). Since this value was over 5000mg/kg (dermal: 2000mg/kg (Category 4) *2.5), it was set as the outside of Category. |
| 1 | Acute toxicity （Inhalation: Gases） | Not applicable | - | - | - | - | Solid (GHS definition) |
| 1 | Acute toxicity （Inhalation: Vapours） | Not classified | - | - | - | - | LC values for rat inhalation exposure: 15000ppm (equivalent 124.79mg/L) (PATTY (5th, 2001), ACGIH (2001)) and LC50: 125000mg/m3 (equivalent: 15000ppm) (RTECS (2004)) are considered to be inhalation steam study, since the saturated vapor pressure concentration at 20degC is 52320ppm or less. Moreover, since it was over the value of 12500ppm (gas 5000ppm (Category 4) *2.5), it was classified as out of Category. |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Classification not possible | - | - | - | - | No data available |
| 2 | Skin corrosion/irritation | Category 2 |
|
Warning | H315: Causes skin irritation |
P302+P352: IF ON SKIN: Wash with plenty of soap and water. P332+P313: If skin irritation occurs: Get medical advice/attention. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection. P321: Specific treatment （see ... on this label）. P362: Take off contaminated clothing and wash before reuse. |
Since erythema (erythema) was accepted with the rabbit (EHC 113 (1990)), it was set as Category 2. |
| 3 | Serious eye damage/eye irritation | Category 2B | - | Warning | H320: Causes eye irritation |
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313: If eye irritation persists: Get medical advice/attention. P264: Wash ... thoroughly after handling. |
As the test results with the guinea pigs is MILD (RTECS(2004), it was set as Category 2B. |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | - | Since there was no data, respiratory sensitizing property could not be classified. |
| 4 | Skin sensitization | Not classified | - | - | - | - | We classified it as "Out Of Category" based on the information (PATTY (5th, 2001)) (EHC 113 (1990)) that it has no sensitizing property for the guinea pigs. |
| 5 | Germ cell mutagenicity | Not classified | - | - | - | - | It was classified as out of Category. Based on the result was negative in dominant lethal examination of the mouse (EHC 113 (1990)) (DFGOT vol.1 (1991)). |
| 6 | Carcinogenicity | Not classified | - | - | - | - | It was considered as the out of Category. Based on the test result that although there is no rating administrative information, carcinogenicity was not observed (DFGOT vol.1 (1991)). |
| 7 | Reproductive toxicity | Classification not possible | - | - | - | - | No data available |
| 8 | Specific target organ toxicity - Single exposure | Classification not possible | - | - | - | - | In rat inhalation exposure, slight decrease in the central nervous system at 10000ppm (4-hour equivalent: 7070ppm), death by the stimulativeness of critical lungs 20000-30000ppm (4-hour equivalent: 10000 - 18000ppm), and death by pulmonary hemorrhage in 5000ppm (4-hour equivalent: 10750 ppm) are acknowledged (PATTY(5th, 2001) DFGOTvol.1 (1991)) but all were the given doses exceeding the guidance value of Category 2, it is not adopted as a category. Since there is no other effective data, it cannot classify. |
| 9 | Specific target organ toxicity - Repeated exposure | Classification not possible | - | - | - | - | Although symptoms were observed in lungs, liver, the spleen, and the central nervous system, all were set to out of Category with the dose exceeding a guidance value. |
| 10 | Aspiration hazard | Classification not possible | - | - | - | - | No data available on chemical pneumonia |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Classification not possible | - | - | - | - | No data available |
| 11 | Hazardous to the aquatic environment （Long-term） | Classification not possible | - | - | - | - | No data available. |
NOTE:
|
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference：
|
Reference Manual |
|
|
Definitions / Abbreviations |
|
|
Model SDS by MHLW |
MHLW Website （in Japanese Only） |