GHS Classification Result

Chemical Name:tetrasodium 3,3'-[(3,3'-dimethyl[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[5-amino-4-hydroxynaphthalene-2,7-disulphonate]
CAS:72-57-1

Result:
ID: 840
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual (10 Feb, 2006)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Classification not possible - - - - No data available
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Classification not possible - - - - No data available
11 Self-heating substances and mixtures Classification not possible - - - - http://www8.cao.go.jp/cstp/index.html
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified - - - - "Sol in water forming a deep blue soln." (Merck, 2006)
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Classification not possible - - - - No data available
15 Organic peroxides Not applicable - - - - Containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - Liquid at a test temperature, 55degC. Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Not classified - - - - Not classified because of SPECIES: Rat; ENDPOINT: LD50; VALUE: :6200mg/kg; REFERENCE SOURCE: HSDB (2006), RTECS (2006)
1 Acute toxicity (Dermal) Classification not possible - - - - No data available
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Solid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - There is description that death was not acknowledged by rat 1-hour exposure (4-hour equivalent 0.1184mg/L) in the 0.4735mg/L concentration (HSDB (2006)). But there is no other data and the category could not be specified. Therefore, it cannot be classified since data is insufficient.
2 Skin corrosion/irritation Classification not possible - - - - There is statement that skin irritations symptoms were not acknowledged by repeated administration in the test which used the rabbit (HSDB (2006)). But there is no statement which negated hazard clearly in Priority 1, it could not be classified due to shortage of data for carrying out the outside of Category.
3 Serious eye damage/eye irritation Classification not possible - - - - There is the description that irritation was not acknowledged, even if it applies to a human eyes (HSDB (2006) and SITTIG (4th, 2002)). But it cannot be classified, since there was no statement which negates hazard clearly in Priority 1, and the data is insufficient for set as the outside of Category.
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Classification not possible - - - - No data available
5 Germ cell mutagenicity Classification not possible - - - - Although there was a positive result with in vivo chromosomal aberration test on rats in RTECS (2006), and it would be classified into Category 2 assuming the target sector was marrow cells and would be Category 1B with spermatogenous cells, the target sector was unknown. So it could not be specified or be classified.
6 Carcinogenicity Category 2 Warning H351: Suspected of causing cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
It was classified into group 2B (IARC Suppl.7, 1987) in IARC and 2B in Japan Assoc. of Industrial Health (industrial hygene academic society recommentation, 2005). So it was considered as Category 2.
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
There is no description of general toxicity of parent animals. However, there is a description that although the route of administration is unknown, teratogenicity was observed in a mouse, a rat, and a guinea pig (IARC 8 (1975)) . Moreover, there is a description that impact on fertility and developmental anomaly were observed in pregnant rat oral administration examination (RTECS (2006)). Therefore, it was classified into Category 2.
8 Specific target organ toxicity - Single exposure Classification not possible - - - - No data available.
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - No data available
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Classification not possible - - - - Insufficient data available.
11 Hazardous to the aquatic environment (Long-term) Classification not possible - - - - Classification not possible due to lack of data


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model SDS by MHLW

MHLW Website (in Japanese Only)


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