GHS Classification Result

Chemical Name：tetranitromethane
CAS：509-14-8

Result：
ID: 841
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not classified - - - - UNRTDG Class: 5.1
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Liquid (GHS definition)
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Not classified - - - - Flash point: >93degC
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - Classified in oxidizing liquids
9 Pyrophoric liquids Not classified - - - - It is classified into the UNRTDG class 5.1.
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Not classified - - - - UNRTDG class 5.1
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Category 1 Danger H271: May cause fire or explosion; strong oxidizer P371+P380+P375: In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
P306+P360: IF ON CLOTHING: Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P370+P378: In case of fire: Use ... for extinction.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P220: Keep/Store away from clothing/.../combustible materials.
P221: Take any precaution to avoid mixing with combustibles/...
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P283: Wear fire/flame resistant/retardant clothing.
P501: Dispose of contents/container to ... 		UNRTDG Class: 5.1; PG I
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Containing no -0-0- structure
16 Corrosive to metals Not classified - - - - UNRTDG Class: 5.1

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 3 Danger H301: Toxic if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ... 		SPECIES: Rat ROUTE ADMIN: ORAL ENDPOINT: LD50 VALUE: 130 mg/kg REFERENCE SOURCE: ACGIH, DFGOT, PATTY, NTP
1 Acute toxicity （Dermal） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Category 1 Danger H330: Fatal if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P284: Wear respiratory protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P320: Specific treatment is urgent （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on rat inhalation LC50 (4 hours): 0.14mg/L (level equivalent: 17.5ppm) (ACGIH and (7th, 2001), DFGOTvol.4 (1992), PATTY (4th, 1994), and NTP TR386 (1990)), it was classified as Category 1. In addition, above-mentioned LC50 value is significantly lower than the saturated vapor concentration of this substance of 11100ppm(equivalent: 88.11mg/m3), the inhalation exposure test was judged to have been conducted with steam which does not include mist.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available
2 Skin corrosion/irritation Not classified - - - - Based on description that "the skin is not also stimulated in repeated exposure in humans" of DFGOTvol.4 (1992) or PATTY (4th, 1994) which are the source of Priority 1, it was considered as the outside of Category. In addition, "The skin is stimulated" is described by ICSC (J)(2004), SITTIG (47th, 2002), HSDB (2005) and HSFS (2000) which are sources of Priority 2. It was judged that all were insufficient for considering as basis of the categories since former references were not indicated.
3 Serious eye damage/eye irritation Category 2A Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection. 		Based on the description that irritation was acknowledged in the eyes in the cases of occupational exposure (ACGIH, DFGOT, and PATTY), it was set as Category 2A.
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Classification not possible - - - - No data available
5 Germ cell mutagenicity Classification not possible - - - - Although multiple indices with in vitro mutagenicity test, such as reverse mutation test which uses bacteria, sister chromatid exchange test (-S9), chromosome aberration test (+S9), using a mammals cultured cell, show positive results (ACGIH (7th, 2001), DFGOTvol.4 (1992), IARC 65 (1996)), the degree of response is unknown. On the other hand, since there is no data of in vivo, and there are not known germ-cell mutagenicities substance which chemical structure similar to this substance, it was judged that there was no finding which suggests potential of having germ-cell mutagenicities in this product. And it was presupposed that it cannot be classified due to data insufficiency.
6 Carcinogenicity Category 2 Warning H351: Suspected of causing cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		It was classified into 2B in IARC 65 (1996), A3 in ACGIH (7th, 2001), 2B in industrial hygene academic society recommentation (2005) and R in NTP RoC (11th, 2005). So it was considered as Category 2.
7 Reproductive toxicity Classification not possible - - - - No data available
8 Specific target organ toxicity - Single exposure Category 3 （Respiratory tract irritation） Warning H335: May cause respiratory irritation (respiratory tract irritation) P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P405: Store locked up.
P501: Dispose of contents/container to ... 		From description that the nose and the tracheal gill were stimulated of exposure in human (ACGIH (7th, 2001), DFGOTvol.4 (1992), PATTY (4th, 1994)), it was thought that there was respiratory irritant and it was set as Category 3.
9 Specific target organ toxicity - Repeated exposure Category 1 (respiratory system, blood) Danger H372: Cause damage to organs through prolonged or repeated exposure (respiratory system, blood) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		Based on in the case of occupational exposure it was observed pulmonary edema and methemoglibinemia (ACGIH (7th, 2001) and DFGOTvol.4 (1992)), and in 13 weeks of rat repetition inhalation test, with 10 ppm exposure (equivalent to 0.08 mg/L, which can be judged to be steam from steam pressure), target organs were considered to be respiratory tracts and blood (ACGIH (7th, 2001), IARC 65 (1996), DFGOTvol.4 (1992), PATTY (4th, 1994), NTP TR386 (1990)), and were classified into Category 1.
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Classification not possible - - - - No data available
11 Hazardous to the aquatic environment （Long-term） Classification not possible - - - - No data available.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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