GHS Classification Result

Chemical Name:D.D.T.
CAS:50-29-3

Result:
ID: 857
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual (10 Feb, 2006)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Classification not possible - - - - Although there are information that it is combustible or that it is incombustible or flame proofs (ICSC (J) (2004)) and (HSDB (2006)), there is no data with defined test method.
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Classification not possible - - - - No data available
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid or solid substances at 140degC are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not applicable - - - - Organic compounds containing chlorine (but not oxygen and fluorine) and the chlorine is chemically bonded only to carbon and hydrogen (but not to other elements).
15 Organic peroxides Not applicable - - - - Containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - Although there is information that it has some corrosiveness to iron or aluminum (HSDB (2006)), test methods suitable for a solids material are not established.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ...
Calculated based on rat LD50 values: 250mg/kg (ACGIH 7th, 2001, PATTY 4th, 1994), 113mg (MOE Risk Assessment the 1st volume, 2002), 240, 280, 420, 940 and 1400mg/kg (PATTY 4th, 1994), 500 - 2500 mg/kg and 113 - 450 mg/kg (EHC 9, 1979) 300, 800, 113, 355.2, 194.5, and 437.8mg/kg (ATSDR, 2002). Since the calculated values was 313mg/kg, it was set as Category 4.
1 Acute toxicity (Dermal) Category 3 Danger H311: Toxic in contact with skin P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P322: Specific treatment (see ... on this label).
P361: Remove/Take off immediately all contaminated clothing.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ...
Calculation was applied by animal classification. Based on rat LD50 values: 2500mg/kg (ACGIH 7th, 2001, MOE Risk Assessment the 1st volume, 2002), 250 - 3000 mg/kg (EHC 9, 1979), 2500 - 3000 mg/kg (ATSDR, 2002), rabbit LD50 values: 300 - 2820 mg/kg (EHC 9, 1979), and 300mg/kg (ATSDR, 2002). The calculated value of rat was 1602mg/kg. And the rabbit one was lower than the lowest value ,the lowest value of 300mg/kg was adopted. Based on the lower toxic value of a rabbit, it was set as Category 3.
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Solid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - No data available
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment (see ... on this label).
P362: Take off contaminated clothing and wash before reuse.
There is description that irritation was not admitted by a human dermal exposure tests (EHC 9 (1979)). But from description that the slight or moderate skin irritation was suggested in the test using the rabbit (PATTY (4th, 1994)), it was set as Category 2.
3 Serious eye damage/eye irritation Category 2B - Warning H320: Causes eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
Based on the description that in the part of in evidence of exposure in humans, the mild irritation which is considered to be by the contact directly to the eyes was acknowledged (ATSDR (2002)), it was set as Category 2B.
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Classification not possible - - - - No data available
5 Germ cell mutagenicity Category 1B Danger H340: May cause genetic defects P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
There were results as positive (ATSDR, 2002) or weakly positive (IARC 53, 1991) with the dominant lethal test on mice which is an in vivo generation mutagenicity test using germ cells. So it was classified as Category 1B.
6 Carcinogenicity Category 2 Warning H351: Suspected of causing cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
It was classified into group 2B (ARC 53, 1991) in IARC, A3 (ACGIH 7th, 2001) in ACGIH, B-2 (IRIS, 2006) in EPA, R (NTP RoC 11th, 2005) in NTP, category 3 (EU-Annex I, 2006) in EU, and 2B (industrial hygene academic society recommentation, 2005) in Japan Assoc. of Industrial Health. So it was considered as Category 2.
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
It was classified into Category 2 based on the description that it is observed of clear reproductive toxicity as reduction of male/female reproductive potential and increase miscarriage and preterm delivery in rat, mouse and rabbit oral administration test (IARC 53 (1991), ATSDR (2002), PATTY (4th, 1994), and EHC 9 (1979)).
8 Specific target organ toxicity - Single exposure Category 1 (nervous system, liver) Danger H370: Causes damage to organs (nervous system, liver) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
It was set as Category 1 (a nervous systems, liver). Based on the descriptions that the effects on the liver and nervous systems in the single-dose oral study used the rat and monkey at the doses of guidance value range of category 1 (ATSDR (2002)), and description that the symptom indicating nervous systems damage as acute effects on humans (MOE Risk Assessment vol. 1(2002), ACGIH (7th, 2001), EHC 9 (1979), IARC 53 (1991), and NTP TR131 (1978)) were acknowledged, and from description that the target organ in the humans after acute exposure is a nervous systems of ATSDR (2002). .
9 Specific target organ toxicity - Repeated exposure Category 1 (liver, nervous system) Danger H372: Cause damage to organs through prolonged or repeated exposure (liver, nervous system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
Based on the description that in the repeated oral administration tests using the rat, the effects on the liver were observed with dosage in the Category 1 guidance value range (MOE Risk Assessment the 1st volume (2002), IRIS (2006), ATSDR (2002), PATTY (4th, 1994), ACGIH (7th, 2001), EHC 9 (1979)), and the description that in the repeated oral administrations test using the rat, the effects on the nervous systems were observed with the dosage a little exceeding the Category 1 guidance value range (NTP TR131 (1978), ATSDR (2002)), it was classified into Category 1 (liver, nervous system).
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
It was classified into Category 1 from two days EC50=0.36microg/L of Crustacea (Daphnia magna), and others (MOE Risk Assessment No.1, 2002).
11 Hazardous to the aquatic environment (Long-term) Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
Classified into Category 1, since acute toxicity is Category 1,not rapidly degrading (BOD: 0% (existing chemical substances safety inspections data)), and bioaccumulative (BCF=25900 (existing chemical substances safety inspections data)).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model SDS by MHLW

MHLW Website (in Japanese Only)


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