GHS Classification Result

Chemical Name：1,2,4-Trichlorobenzene
CAS：120-82-1

Result：
ID: 860
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Not classified - - - - Flash point: >93degC
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not classified - - - - Flash point: >500degC (Ullmanns (E), 5th, 1995, A6: p328-333)
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not classified - - - - Organic compounds containing chlorine (but not oxygen and fluorine) chemically bonded only to carbon and hydrogen (but not to other elements).
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Containing no -0-0- structure
16 Corrosive to metals Not classified - - - - UNRTDG Class: 6.1

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		Calculated based on the following data: Rat LD50 value: 756mg/kg (DFGOT vol.3, 1992, ACGIH 7th, 2001, EHC 128, 1991, EU-RAR, 2003), 880mg/kg (DFGOT vol.3, 1992, ACGIH 7th, 2001), 930mg/kg (DFGOT vol.3, 1992, EU-RAR, 2003), and 1019mg/kg (DFGOT vol.3, 1992, ACGIH 7th, 2001, EU-RAR, 2003). Since the calculated values was 806.2mg/kg, it was classified to category 4.
1 Acute toxicity （Dermal） Not classified - - - - Based on rat LD50 values: 6139mg/kg (DFGOT vol. 3, 1992, and ACGIH 7 th2001, EHC128, 1991, EU-RAR, 2003), 11415mg/kg (DFGOT vol. 3, 1992, and ACGIH 7 th, 2001, EU-RAR, 2003), and approximately 5000mg/kg (EU-RAR, 2003) and >5000mg/kg (EU-RAR, 2003), it was considered as the outside of Category.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - There was description that death was not acknowledged by 418ppm (equivalent 3.1mg/L) 4-hour exposure in rats (EU-RAR (2003)). But there is no other data, and the category could not be specified. Therefore, it cannot be classified since data is insufficient.
2 Skin corrosion/irritation Category 3 - Warning H316: Causes mild skin irritation P332+P313: If skin irritation occurs: Get medical advice/attention. It was set as Category 3 from description that very slight stimulativeness was acknowledged in the animal experiments according to the OECD Guidelines (EU-RAR (2003)).
3 Serious eye damage/eye irritation Not classified - - - - There is the description that in the animal experiments complied with the OECD Guidelines of EU-RAR (2003), effect was not acknowledged in corneal and iris, and the description that in the test applied to the eye of the rabbit, effect was not acknowledged in a corneal (EHC 128 (1991), DFGOT vol.3 (1992), EU-RAR (2003)). As judging that it is not applicable to the acceptance criteria of irritation, it was set as the outside of Category.
4 Respiratory sensitization Classification not possible - - - - No data
4 Skin sensitization Not classified - - - - We classified it as Out Of Category based on the description that positive rates were 10% or less in maximization test using the guinea pigs in EU-RAR (2003).
5 Germ cell mutagenicity Not classified - - - - Since there was a negative result with the micronucleus test on mouse red corpuscles, which is an in vivo mutagenicity test using somatic cells (EHC 128, 1991, DFGOT vol.14, 2000, EU-RAR, 2003), it was classified as out of Category.
6 Carcinogenicity Not classified - - - - Since it was classified into D in EPA (IRIS, 2005), it was considered as the outside of Category.
7 Reproductive toxicity Not classified - - - - It was considered as out of Category based on the description that specific reproductive toxicity was not observed at the dose causing general toxicity to parental animals in pregnant rat oral administration examination and in the rat multigeneration reproductivre study (EHC 128 (1991), DFGOT (vol.3, 1992), PATTY (4th, 1994), EU-RAR (2003), IRIS (2005)).
8 Specific target organ toxicity - Single exposure Category 3 （Respiratory tract irritation, Narcotic effects） Warning H336: May cause drowsiness or dizziness (respiratory tract irritation, narcotic effects)
H335: May cause respiratory irritation (respiratory tract irritation, narcotic effects) 		P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P405: Store locked up.
P501: Dispose of contents/container to ... 		From description in EU-RAR (2003), ACGIH (7th, 2001), and DFGOT (vol.3, 1992) that a throat is stimulated as effect on humans, and description in DFGOT (vol.3, 1992) that the anesthetic actions was seen in the oral study on rats, it was set as Category 3 (respiratory irritation, anesthetic actions).
9 Specific target organ toxicity - Repeated exposure Category 2 (liver, thyroid, kidney, adrenal gland) Warning H373: May cause damage to organs through prolonged or repeated exposure (liver, thyroid, kidney, adrenal gland) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		Based on the description that in feeding oral administration tests using the rat, the effects on the liver and thyroid were observed with the dosage in the Category 2 guidance value range (EHC 128 (1991), DFGOT (vol.3, 1992), EU-RAR (2003)), the description that in the feeding oral administration tests using the rat, the effects on the liver and kidney were observed with the dosage in the Category 2 guidance value range (PATTY (4th, 1994), EU-RAR (2003)), and the description that in the oral administration tests using the rat, the effects on the adrenal gland were observed with the dosage in the Category 2 guidance value range (IRIS (2005)), it was classified into Category 2 (liver, thyroid, kidney, adrenal gland). In addition, although ACGIH (7th, 2001) has description that hepatotoxicity may be occured in high exposure levels, as the effects on human, it was classified into Category 2, since the concrete case was not indicated, and it could not fully be sure to justify the classification to Category 1.
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		It was classified into Category 1 from 96-hour EC50=0.45mg/L of Crustacea (Mysid shrimp), and others (EU-RAR, 2003).
11 Hazardous to the aquatic environment （Long-term） Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Classified into Category 1, since acute toxicity is Category 1,not rapidly degrading (BOD: 0% (existing chemical substances safety inspections data)), and bioaccumulative (BCF=1320 (existing chemical substances safety inspections data)).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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