GHS Classification Result

Chemical Name：cyhexatin
CAS：13121-70-5

Result：
ID: 863
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Classification not possible - - - - No data available
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Classification not possible - - - - No data available
11 Self-heating substances and mixtures Classification not possible - - - - No data available
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified - - - - Not cause a serious reaction with water. (HSDB, 2005)
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Classification not possible - - - - No data available
15 Organic peroxides Not applicable - - - - Containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		It was classified to category 4 based on the data of Rat LD50 value: 540mg/kg (ACGIH 7th, 2001 and EHC 15, 1980).
1 Acute toxicity （Dermal） Category 2 Danger H310: Fatal in contact with skin P302+P350: IF ON SKIN: Gently wash with plenty of soap and water.
P262: Do not get in eyes, on skin, or on clothing.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P322: Specific treatment （see ... on this label）.
P361: Remove/Take off immediately all contaminated clothing.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Rat LD50 values = 446mg/kg , and rabbit LD50 value = 2422mg/kg (RTECS2005 and HSDB2005). Based on the lower rat LD50 value, it was set as Category 2.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Solid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - Classification not possible due to lack of data
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P362: Take off contaminated clothing and wash before reuse. 		There is description that the skin was not stimulated by 0.01mg/kg exposure to humans (EHC 15 (1980)). But from description that the skin irritation responses were acknowledged by single sprays to the sheep (ACGIH (7th, 2001)), and description that the skin reactions were acknowledged by repeated skin exposure to the rabbit (EHC 15 (1980)). So it was judged that there was skin irritation and it was set as Category 2.
3 Serious eye damage/eye irritation Category 2A-2B Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection. 		There was no data of the test which applied directly to the eye of the animal. But based on the description that eye irritations were acknowledged by single spray to the goat (ACGIH (7th, 2001), EHC 15 (1980)), it was set as Category 2A-2B.
4 Respiratory sensitization Classification not possible - - - - No data
4 Skin sensitization Not classified - - - - We classified it as Out Of Category based on the description that no reaction was acknowledged in the skin sensitivity test for the human in EHC 15 (1980).
5 Germ cell mutagenicity Classification not possible - - - - No data available
6 Carcinogenicity Not classified - - - - Not classified because of "A4" (ACGIH, 7th, 2001)
7 Reproductive toxicity Not classified - - - - It was considered as out of Category based on the description that effect was not observed in the reproductive function, fertility or development of children in the rat three-generation reproductive test, and in the 8-16 days pregnant rabbit administration test (ACGIH (7th, 2001) and EHC 15 (1980)) .
8 Specific target organ toxicity - Single exposure Category 1 (central nervous system, gastrointestinal tract), Category 3 (respiratory tract irritation) Danger
Warning 		H370: Causes damage to organs (central nervous system, gastrointestinal tract)
H335: May cause respiratory irritation (respiratory tract irritation) 		P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ...
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell. 		From description in EHC 15 (1980) and ACGIH (7th, 2001) that central nervous systems depressions and watery diarrheas were seen with the given dose of the guidance value range of Category 1 in the infusion test into the sheep rumen, it was set as Category 1 (a central nervous systems, a gastrointestinal). Moreover, it was set as Category 3 (respiratory irritant) from description in HSFS (2002) and SITTIG (4th, 2002) that the nose and throat are stimulated.
9 Specific target organ toxicity - Repeated exposure Category 1 (gastrointestinal tract, kidney, liver) Danger H372: Cause damage to organs through prolonged or repeated exposure (gastrointestinal tract, kidney, liver) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		Based on the description that the inflammation of digestive tracts, nephropathy and liver cholangitis in the 19-days oral study using the rat, and nephropathy and cholangitis in the 90-days feeding oral administration tests using a rat were observed with the dosage in the Category 1 guidance value range respectively (EHC 15 (1980)), it was classified into Category 1 all, since digestive tracts, kidney and liver are considered as the target organs.
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		It was classified into Category 1 from 96-hour LC50=6.7microg/L of fishes (Bluegill) (HSDB, 2004).
11 Hazardous to the aquatic environment （Long-term） Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Classified into Category 1, since acute toxicity is Category 1, supposed not rapidly degrading (BIOWIN), and bioaccumulative (log Kow=6.63 (PHYSPROP Database, 2005)).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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