GHS Classification Result

Chemical Name：Sulfur dioxide
CAS：7446-09-5

Result：
ID: 872
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - Gas (GHS definition)
2 Flammable gases （including chemically unstable gases） Not classified - - - - Non-combustible (Merck, 2005; etc.)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not classified - - - - Not classified in UNRTDG Subsidiary risks Class: 5.1
5 Gases under pressure Liquefied gas Warning H280: Contains gas under pressure; may explode if heated P410+P403: Protect from sunlight. Store in a well-ventilated place. Critical temp: >-50degC (Partially liquid at temperatures above -50degC)
6 Flammable liquids Not applicable - - - - Gas (GHS definition)
7 Flammable solids Not applicable - - - - Gas (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - Gas (GHS definition)
9 Pyrophoric liquids Not applicable - - - - Gas (GHS definition)
10 Pyrophoric solids Not applicable - - - - Gas (GHS definition)
11 Self-heating substances and mixtures Not applicable - - - - Gas (GHS definition)
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Gas (GHS definition)
13 Oxidizing liquids Not applicable - - - - Gas (GHS definition)
14 Oxidizing solids Not applicable - - - - Gas (GHS definition)
15 Organic peroxides Not applicable - - - - Gas (GHS definition)
16 Corrosive to metals Classification not possible - - - - Although there is information that it corrodes aluminum (HSDB (2005)), test methods suitable for gaseous substances are not established.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Not applicable - - - - Gas (GHS definition)
1 Acute toxicity （Dermal） Not applicable - - - - Gas (GHS definition)
1 Acute toxicity （Inhalation: Gases） Category 3 Danger H331: Toxic if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P311: Call a POISON CENTER or doctor/physician.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		LC50 value of the study was judged to 593 - 1319ppm, and it was considered as Category 3. This is from description that death is not observed at 593ppm, three of eight examples died at 965ppm, five of eight examples died at 1168ppm, and the all eight examples died at 1319ppm in the rat 4-hour inhalation exposure test (ATSDR (1998)).
1 Acute toxicity （Inhalation: Vapours） Not applicable - - - - Gas (GHS definition)
1 Acute toxicity （Inhalation: Dusts and mists） Not applicable - - - - Gas (GHS definition)
2 Skin corrosion/irritation Classification not possible - - - - No data available
3 Serious eye damage/eye irritation Category 2A Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection. 		There is the description that in high concentrations evidence of exposure in the humans, reversible conjunctivitis and burn of corneal surface were acknowledged (ATSDR (1998)). As judging that there were eye irritations, it was set as Category 2A.
4 Respiratory sensitization Classification not possible - - - - Since data was insufficient, we could not classify it.
4 Skin sensitization Classification not possible - - - - Since data was insufficient, we could not classify it.
5 Germ cell mutagenicity Classification not possible - - - - Classification not possible due to lack of data
6 Carcinogenicity Not classified - - - - Since it was classified into a group 3 (IARC 54, 1992) in IARC and A4 (ACGIH 7th, 2001) in ACGIH, it was considered as the outside of Category.
7 Reproductive toxicity Classification not possible - - - - There is a desctiption that specific reproductive toxicity was not observed in inhalation exposure test using pregnant mice and rabbits (IARC 54 (1992) and ATSDR (1998)). However, general toxicity of parent animals is not observed, either. Therefore, the data was not enough to be classified as out of Category, it is unclassifiable due to insufficient date.
8 Specific target organ toxicity - Single exposure Category 1 (respiratory system) Danger H370: Causes damage to organs (respiratory system) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		From description in EHC 8 (1979), ACGIH (7th, 2001), IARC 54 (1992) and ATSDR (1998) that in the inhalation exposure test using guinea pigs, dogs, rabbits, and rats, airway mucosa irritation, increased airway resistances and respiratory ciliary loss are seen by the concentration of the guidance value range of Category 1, and that decreases respiratory function, such as an increase in airway resistance, was seen also in the inhalation exposure test in humans. And description in IARC 54 (1992) that pulmonary edemas was seen in evidence of concentrated accidental exposure, it was set as Category 1 (respiratory tracts).
9 Specific target organ toxicity - Repeated exposure Category 1 (respiratory system) Danger H372: Cause damage to organs through prolonged or repeated exposure (respiratory system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		Based on the description that in the inhalation exposure test using the rat and guinea pig, pneumonia and bronchitis were observed with the concentration in the Category 1 guidance value range (EHC 8 (1979) and ATSDR (1998)), it was classified into Category 1 (respiratory systems).
10 Aspiration hazard Not applicable - - - - Gas (GHS definition)

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Classification not possible - - - - Insufficient data available.
11 Hazardous to the aquatic environment （Long-term） Classification not possible - - - - Classification not possible due to lack of data


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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