NITE - Chemical Management Field

GHS Classification Result

Chemical Name：Chlorine dioxide
CAS：10049-04-4

Result：


ID:	873
Classifier:	Inter-ministerial Committee on GHS
Year Classified:	FY2006
Reference Manual:	GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Explosives	Not applicable	-	-	-	-	Gas (GHS definition)
2	Flammable gases （including chemically unstable gases）	Classification not possible	-	-	-	-	No data available by regulated test methods (there is a lot of information with "high explosive" and "Non-combustible")
3	Aerosols	Not applicable	-	-	-	-	Not aerosol products
4	Oxidizing gases	Classification not possible	-	-	-	-	No data available by regulated test methods ("strong oxidizing agent"according to some reports)
5	Gases under pressure	Classification not possible	-	-	-	-	Classification not possible due to lack of data
6	Flammable liquids	Not applicable	-	-	-	-	Gas (GHS definition)
7	Flammable solids	Not applicable	-	-	-	-	Gas (GHS definition)
8	Self-reactive substances and mixtures	Not applicable	-	-	-	-	Gas (GHS definition)
9	Pyrophoric liquids	Not applicable	-	-	-	-	Gas (GHS definition)
10	Pyrophoric solids	Not applicable	-	-	-	-	Gas (GHS definition)
11	Self-heating substances and mixtures	Not applicable	-	-	-	-	Gas (GHS definition)
12	Substances and mixtures which, in contact with water, emit flammable gases	Not applicable	-	-	-	-	Gas (GHS definition)
13	Oxidizing liquids	Not applicable	-	-	-	-	Gas (GHS definition)
14	Oxidizing solids	Not applicable	-	-	-	-	Gas (GHS definition)
15	Organic peroxides	Not applicable	-	-	-	-	Gas (GHS definition)
16	Corrosive to metals	Classification not possible	-	-	-	-	Test methods applicable to gas substances are not available

HEALTH HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Acute toxicity （Oral）	Not applicable	-	-	-	-	Gas (GHS definition)
1	Acute toxicity （Dermal）	Not applicable	-	-	-	-	Gas (GHS definition)
1	Acute toxicity （Inhalation: Gases）	Category 1		Danger	H330: Fatal if inhaled	P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P284: Wear respiratory protection. P310: Immediately call a POISON CENTER or doctor/physician. P320: Specific treatment is urgent （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ...	It was considerd as Category 1 based on rat LC50 (4 hours) value: 32ppm (CICAD 37, 2002).
1	Acute toxicity （Inhalation: Vapours）	Not applicable	-	-	-	-	Gas (GHS definition)
1	Acute toxicity （Inhalation: Dusts and mists）	Not applicable	-	-	-	-	Gas (GHS definition)
2	Skin corrosion/irritation	Category 2		Warning	H315: Causes skin irritation	P302+P352: IF ON SKIN: Wash with plenty of soap and water. P332+P313: If skin irritation occurs: Get medical advice/attention. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection. P321: Specific treatment （see ... on this label）. P362: Take off contaminated clothing and wash before reuse.	It was set as Category 2 from description that the skin was stimulated seriously (ICSC (J)(1999), HSDB (2005)).
3	Serious eye damage/eye irritation	Category 2A		Warning	H319: Causes serious eye irritation	P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313: If eye irritation persists: Get medical advice/attention. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection.	There is the description that in evidence of exposure in humans eye irritations were acknowldged (CICAD 37 (2002)), and the description that the eyes are stimulated seriously (ICSC (J)(1999)). So it was set as Category 2A.
4	Respiratory sensitization	Classification not possible	-	-	-	-	No data available
4	Skin sensitization	Classification not possible	-	-	-	-	No data available
5	Germ cell mutagenicity	Category 2		Warning	H341: Suspected of causing genetic defects	P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ...	There are negative result with dominant lethal test on mice (CICAD 37, 2002), negative result with chromosome aberration test on mouse marrow cells, which is an in vivo mutagenicity test using somatic cells (CICAD 37, 2002, ATSDR, 2004, IRIS, 2006), and negative result with micronucleus test by oral administration which used the mouse erythrocytes (CICAD 37, 2002, ATSDR, 2004, IRIS, 2006). But there is a positive result with micronucleus test which used the mouse erythrocytes by the medication in the abdominal cavity (ACGIH 7th, 2001, PATTY 4th, 1994, ATSDR, 2004, IRIS, 2006), and there was no positive result with productive cell in vivo genotoxicity study. So it was classified as Category 2.
6	Carcinogenicity	Not classified	-	-	-	-	Since it was classified into Group D in EPA (IRIS, 2000), it was considered as the outside of Category.
7	Reproductive toxicity	Not classified	-	-	-	-	It was considered as out of Category based on the description that effect was not observed in fertility in rat one generation administration in drinking water reproduction study (CICAD 37 (2002), ATSDR (2004), and IRIS (2005)), and the description that clear reproductive toxicity was not observed in administration in drinking water test to female rat from premating to pregnant period at dose causing general toxicity to maternal animals.
8	Specific target organ toxicity - Single exposure	Category 1 (respiratory system)		Danger	H370: Causes damage to organs (respiratory system)	P307+P311: IF exposed: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ...	From description in CICAD 37 (2002), ATSDR (2004), and IRIS (2005) that pulmonary edemas was seen at the concentration of the guidance value range of Category 1 in the single inhalation exposure tests which used rats, and description in ATSDR (2004) and IRIS (2005) that dyspnea and decreased respiratory function was seen in humans in evidence of exposure, respiratory systems was considered to be the target organ, and was set as Category 1.
9	Specific target organ toxicity - Repeated exposure	Category 1 (respiratory system)		Danger	H372: Cause damage to organs through prolonged or repeated exposure (respiratory system)	P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ...	Based on the description that in the occupational evidence of exposure in humans, the effects on the respiratory systems were observed (ACGIH (7th, 2001), PATTY (4th, 1994),CICAD 37 (2002), ATSDR (2004), and IRIS (2005)), and the description that in the repeated inhalation exposures test using the rat and rabbit, the effects on the respiratory systems were observed with the concentration in the Category 1 guidance value range (CICAD 37 (2002), ATSDR (2004), and IRIS (2005)), it was classified into Category 1, since respiratory systems were considered to be target organs.
10	Aspiration hazard	Not applicable	-	-	-	-	Gas (GHS definition)

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
11	Hazardous to the aquatic environment （Acute）	Category 1		Warning	H400: Very toxic to aquatic life	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	It was classified into Category 1 from 96-hour LC50=0.02-0.17mg/L of fishes (Fathead minnows), and others (CICAD37, 2002).
11	Hazardous to the aquatic environment （Long-term）	Category 1		Warning	H410: Very toxic to aquatic life with long lasting effects	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	Classified into Category 1, since acute toxicity was Category 1, and behavior in water and bioaccumulative potential are unknown.

NOTE:

* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：

Reference Manual
Definitions / Abbreviations
Model SDS by MHLW	MHLW Website （in Japanese Only）