GHS Classification Result

Chemical Name：2-Nitrotoluene
CAS：88-72-2

Result：
ID: 880
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not classified - - - - UNRTDG Class: 6.1
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Not classified - - - - Flash point: >93degC, UNRTDG Class: 6.1
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not classified - - - - Classified in UNRTDG Class: 6.1
9 Pyrophoric liquids Not classified - - - - Flash point: 420degC (ICSC (J), 2000)
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Not classified - - - - UNRTDG Class: 6.1
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not classified - - - - UNRTDG Class: 6.1
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Containing no -0-0- structure
16 Corrosive to metals Not classified - - - - UNRTDG Class: 6.1

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		Calculated based on the rat LD50 value: 890mg/kg (CERI Hazard Data, 1999, DFGOT vol.8, and 1997), 891mg/kg (NTP TR 504, 2002, IARC 65, 1996), 2100mg/kg(IARC 65, 1996) and 2546mg/kg (CERI Hazard Data, 1999, DFGOT vol.8, 1997). Since the calculated value was 1221mg/kg, it was classified to category 4.
1 Acute toxicity （Dermal） Not classified - - - - Based on rat LD50 value: >5000mg/kg (CERI Hazard Data, 1999), it was set as the outside of Category.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - There is description that rat LC50 (8 hours) value: >197ppm (4-hour equivalent >1.56mg/L) (CERI Hazard Data(1999)). But there is no other data, and data is insufficient, it cannot be classified.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available
2 Skin corrosion/irritation Not classified - - - - It was carried out the outside of Category from description that irritation was not indicated in the skin of the rabbit on CERI Hazard Data (1999) and DFGOT (vol.8, 1997).
3 Serious eye damage/eye irritation Not classified - - - - Based on the description that the eye is not stimulated (DFGOT (vol.8, 1997)), it was set as the outside of Category.
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Classification not possible - - - - No data available
5 Germ cell mutagenicity Not classified - - - - Since there was a negative result (NTP TR 504, 2002) with micronucleus test on rat and mouse red corpuscles which is an in vivo mutagenicity test using somatic cells, it was classified as out of Category.
6 Carcinogenicity Not classified - - - - It was classified into category 2 (EU-Annex I, 2005) in EU. But it was classified into the group 3 (IARC 65, 1996) in IARC. So it was considered as the outside of Category. Expert judgement is required for appropriateness of the categories.
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		It was classified into Categoty 2 based on the description that the denaturation of a testis, the reduction of sperm motility, decrease of a sperm count, and extension of the female estrous cycle were observed at the dose causing the decreased weight gains in the rat feeding oral administration tests during 90 days (DFGOT (vol.8, 1997), IARC 65 (1996), ACGIH (7th, 2001)).
8 Specific target organ toxicity - Single exposure Category 1 (blood), Category 3 (narcotic effects) Danger
Warning 		H370: Causes damage to organs (blood)
H336: May cause drowsiness or dizziness (narcotic effects) 		P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ...
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell. 		It was set as Category 1 (blood), from description in ACGIH (7th, 2001), PATTY (4th, 1994), and CERI Hazard Data (1999) that methemoglobinemia is caused. Moreover, CERI Hazard Data (1999) shows that influence on the central nervous system, which is considered to be transient, was seen in the oral administration examination using rats and the dermal administration test using rabbits, it was judged that there was an anesthetic actions and was set as Category 3 (anesthetic actions).
9 Specific target organ toxicity - Repeated exposure Category 1 (blood), Category 2 (liver) Danger
Warning 		H372: Cause damage to organs through prolonged or repeated exposure (blood)
H373: May cause damage to organs through prolonged or repeated exposure (liver) 		P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		Based on the description that anemia is occured in chronic exposures (PATTY (4th, 1994)), it was classified into Category 1 (blood). Based on the description that in the 14-days feeding oral administration tests using the rat, the effects on the liver were observed with the dosage a little exceeding the Category 2 guidance value range (CERI Hazard Data (1999), DFGOT (vol.8, 1997), IARC 65 (1996)), it was classified into Category 2 (liver).
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 2 - - H401: Toxic to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		It was classified into Category 2 from 48-hour EC50=5.4 mg/L of Crustacea (Daphnia magna) (CERI Hazard Data, 2000).
11 Hazardous to the aquatic environment （Long-term） Category 2 - H411: Toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Classified into Category 2, since acute toxicity was Category 2 and not rapidly degrading (BOD: 0.5% (existing chemical safety inspections data)), though less bio-accumulative (BCF=29.9 (existing chemical safety inspections data)).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

To GHS Information