GHS Classification Result

Chemical Name：Propane, 2-nitro-
CAS：79-46-9

Result：
ID: 885
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not classified - - - - UNRTDG Class: 3
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Category 3 Warning H226: Flammable liquid and vapour P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P233: Keep container tightly closed.
P240: Ground/bond container and receiving equipment.
P241: Use explosion-proof electrical/ventilating/lighting/.../equipment.
P242: Use only non-sparking tools.
P243: Take precautionary measures against static discharge.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ... 		Flash point: >=23degC and <=60degC, UNRTDG Class: 3, PGIII
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not classified - - - - Classified in UNRTDG Class: 3
9 Pyrophoric liquids Not classified - - - - Flash point: 425degC (Hommel, 1991 Card No.298)
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not classified - - - - UNRTDG Class: 3
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Containing no -0-0- structure
16 Corrosive to metals Not classified - - - - UNRTDG Class: 3

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		Category 4 based on SPECIES: Rat; ENDPOINT: LD50; VALUE: :720mg/kg; REFERENCE SOURCE: ACGIH 7th (2001)
1 Acute toxicity （Dermal） Not classified - - - - From the description that effect was not observed at 2000mg/kg in the single dermal administration test using rabbits (EHC 138 (1992)), it was set as the outside of Category.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Category 2 Danger H330: Fatal if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P284: Wear respiratory protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P320: Specific treatment is urgent （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on rat LC50 (6 hours) value: 400ppm (4-hour converted values 1.78mg/L) (ACGIH 7th, 2001, IARC 29, 1982, EHC 138, 1992), 1.78mg/L was judged to be vapor with almost no mist from its vapor pressure, and it was classified by the ppm concentration standard. 1.78mg/L was converted to 489ppm using conversion factor 1ppm = 3.64mg/m3, and it was classified as Category 2.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available
2 Skin corrosion/irritation Not classified - - - - From description that when applied to the skin of the rabbit on EHC 138 (1992), local effects were not admitted, it was carried out the outside of Category.
3 Serious eye damage/eye irritation Classification not possible - - - - There is the description that in the test applied to the eye of the rabbit, irritation was not acknowledged (IUCLID (2000)). It could be set as the outside of Category, but there is no data which negates hazard clearly in Priority1. So it cannot be classified.
4 Respiratory sensitization Classification not possible - - - - No data
4 Skin sensitization Classification not possible - - - - Although there was a possibility that it is classified as Out Of Category based on the description that skin sensitizing property was not acknowledged in the study using the guinea pigs in IUCLID (2000), we presupposed that we could not classify it since there was no data in Priority 1 which negates hazardousness clearly.
5 Germ cell mutagenicity Not classified - - - - There are negative results with dominant lethal test on rats and mice (ACGIH 7th, 2001, DFGOT vol.3, 1992, EHC 138, 1992), micronucleus test on rat and mouse red corpuscles, which is an in vivo mutagenicity test using somatic cells (IARC 71, 1999, ACGIH 7th, 2001, DFGOT vol.3, 1992, PATTY 4th, 1994, EHC 138, 1992), mouse spot test (DFGOT vol.3, 1992) and chromosome aberration test on rat myeloid cells (EHC 138, 1992). So it was classified as out of Category.
6 Carcinogenicity Category 2 Warning H351: Suspected of causing cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		It was classified into a category 2 in EU (EU-Annex I, 2005). But it was classified into 2B (IARC 71, 1999) in IARC and in Japan Assoc. of Industrial Health (industrial hygene academic society magazine 47, 2005), A3 (ACGIH 7th, 2001) in ACGIH and R (NTP RoC 11th, 2005) in NTP. So it was considered as Category 2.
7 Reproductive toxicity Classification not possible - - - - No data available
8 Specific target organ toxicity - Single exposure Category 1 (liver, blood) Danger H370: Causes damage to organs (liver, blood) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		From description in IARC 71(1999), ACGIH (7th, 2001), DFGOT (vol.3, 1992), EHC 138 (1992) PATTY (4th, 1994) and IRIS (2005) that a liver damages was seen in humans by high exposure levels, and from description in ACGIH (7th, 2001) and EHC 138 (1992) that the effects on blood was seen at the concentration of the guidance value range of Category 1 in the inhalation exposure test using the rabbits, it was set as Category 1 (liver, blood).
9 Specific target organ toxicity - Repeated exposure Category 1 (nervous system), Category 2 (liver, blood, lung, kidney) Danger
Warning 		H372: Cause damage to organs through prolonged or repeated exposure (nervous system)
H373: May cause damage to organs through prolonged or repeated exposure (liver, blood, lung, kidney) 		P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		Based on the description that in the occupational evidence of exposure in humans, the nausea, emesis, lanorexia, severe headaches are observed (IARC 29 (1982), ACGIH (7th, 2001), DFGOT (3 vol. 1992), and EHC 138 (1992)), it was classified into Category 1(nervous systems), since it is assumed that the nervous systems was affected. Moreover, based on the description that in the repeated oral administration test using the rat, the effects on the liver and blood were observed with the dosage in the Category 2 guidance value range (EHC 138 (1992)), and the description that in the repeated inhalation exposures test using the rat, mouse, and rabbit, the effects on the liver, lung, and kidney were observed with concentration in the Category 2 guidance value range (IARC 29 (1982), EHC 138 (1992), and IRIS (2005)), it was classified into Category 2(liver, blood, lung, and kidney).
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Not classified - - - - It carried out the outside of Category from 96-hour LC50>210 mg/L of fishes (Fathead minnows) (EHC138, 1992).
11 Hazardous to the aquatic environment （Long-term） Not classified - - - - Since not water-insoluble (water solubility=17000mg/L(PHYSPROP Database, 2005)) and acute toxicity is low.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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