GHS Classification Result

Chemical Name:Methane, nitro-
CAS:75-52-5

Result:
ID: 886
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual (10 Feb, 2006)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not classified - - - - UNRTDG Class: 3
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Category 3 Warning H226: Flammable liquid and vapour P303+P361+P353: IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P233: Keep container tightly closed.
P240: Ground/bond container and receiving equipment.
P241: Use explosion-proof electrical/ventilating/lighting/.../equipment.
P242: Use only non-sparking tools.
P243: Take precautionary measures against static discharge.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ...
23 degC<= flash point <=60 degC [special note] Although this product is classified as Category 2 with UNRTDG classification, flash point data obtained from all materials were clearly more than 23 degC. So it was classified as Category 3. But expert judgement is required for its validation.
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not classified - - - - Classified in UNRTDG Class: 3
9 Pyrophoric liquids Not classified - - - - Flash point: 415degC (Hommel, 1991 Card No.297)
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Not classified - - - - UNRTDG Class: 3
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not classified - - - - UNRTDG Class: 3
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Containing no -0-0- structure
16 Corrosive to metals Not classified - - - - UNRTDG Class: 3

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ...
Category 4 based on SPECIES: Rat; ENDPOINT: LD50; VALUE: :940mg/kg; (NTP TR 461, 1997), 1210mg/kg; REFERENCE SOURCE: ACGIH 7th, 2001, DFGOT vol.19, 2003, NTP TR 461, 1997)
1 Acute toxicity (Dermal) Classification not possible - - - - No data available
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - No data available
2 Skin corrosion/irritation Category 3 - Warning H316: Causes mild skin irritation P332+P313: If skin irritation occurs: Get medical advice/attention. It was set as Category 3 from description that the skin of the humans was stimulated slightly (ACGIH (7th, 2001), DFGOT (vol.19, 2003)).
3 Serious eye damage/eye irritation Category 2A-2B Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
Based on the description that the eye is not stimulated (ICSC (J) (1999)), it was set as Category 2A-2B.
4 Respiratory sensitization Classification not possible - - - - No data
4 Skin sensitization Classification not possible - - - - Although there was a possibility that it is classified to be Out Of Category based on the description that skin sensitizing property was not acknowledged in the study using the guinea pigs in IUCLID (2000), we presupposed that we could not classify it because of insufficiency of data.
5 Germ cell mutagenicity Not classified - - - - There is a negative result with micronucleus test on mouse red corpuscles which is an in vivo mutagenicity test using somatic cells (ACGIH 7th, 2001, DFGOT vol.19, 2003, IARC 77, 2000, NTP DB, 2005). So it was classified as out of Category.
6 Carcinogenicity Category 2 Warning H351: Suspected of causing cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
It was classified into group 2B (IARC 77, 2000)in IARC, 2B (industrial hygene academic society magazine 47, 2005) in Japan Assoc. of Industrial Health and A3 (ACGIH 7th, 2001) in ACGIH. So it was considered as Category 2.
7 Reproductive toxicity Classification not possible - - - - Although low sperm count and reduction of sperm motility are observed in the rat and mouse 13-week inhalation exposure test (ACIGH (7th, 2001) and IARC 77 (2000)), it cannot be classified due to absent of data about whether it is clear or not,
8 Specific target organ toxicity - Single exposure Category 1 (liver), Category 2 (kidney), Category 3 (respiratory tract irritation) Danger
Warning
H370: Causes damage to organs (liver)
H371: May cause damage to organs (kidney)
H335: May cause respiratory irritation (respiratory tract irritation)
P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician.
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
From description in NTP TR 461 (1997) that the influence on liver was seen in the oral administration study at guidance value within the limits of Category 1 using dogs, from description that the renal influence was seen at guidance value within the limits of Category 2, it was set as Category 1 (liver) and Category 2 (kidney). Moreover, it was set as Category 3 (respiratory irritant) from description in DFGOT (vol.19, 2003) that respiratory irritant was seen in the inhalation exposure test using rabbits and guinea pigs.
9 Specific target organ toxicity - Repeated exposure Category 2 (liver, blood, respiratory system, nervous system) Warning H373: May cause damage to organs through prolonged or repeated exposure (liver, blood, respiratory system, nervous system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
Based on the description that respectively the effects on the liver in the oral study using the rat, and the effects on the blood, respiratory systems, and nervous systems in the repeated inhalation exposures test using the rat or mouse were o bserved with the dosage a little exceeding the Category 2 guidance value range (ACGIH (7th, 2001), DFGOT (vol.19, 2003), PATTY (4th, 1994), IARC 77 (2000), or NTP TR 461 (1997)), it was classified into Category 2(liver, blood, respiratory systems, and nervous systems).
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 3 - - H402: Harmful to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ...
It was classified into Category 3 from 72-hour ErC50=ca.36mg/L of algae (Scenedesmus) (IUCLID, 2000).
11 Hazardous to the aquatic environment (Long-term) Category 3 - - H412: Harmful to aquatic life with long lasting effects P273: Avoid release to the environment.
P501: Dispose of contents/container to ...
Classified into Category 3, since acute toxicity was Category 3 and not rapidly degrading (BOD: 4% (existing chemical safety inspections data)), though less bio-accumulative (log Kow=-0.35(PHYSPROP Database, 2005)).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

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