GHS Classification Result

Chemical Name：4-dimethylaminoazobenzene
CAS：60-11-7

Result：
ID: 894
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Classification not possible - - - - No data available
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Classification not possible - - - - No data available
11 Self-heating substances and mixtures Classification not possible - - - - No data available
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not applicable - - - - Containing no oxygen , chlorine and fluorine.
15 Organic peroxides Not applicable - - - - Containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 3 Danger H301: Toxic if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the rat LD50 value = 200mg/kg (RTECS (Access on July 2005)), the value was classified to category 3.
1 Acute toxicity （Dermal） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Solid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P362: Take off contaminated clothing and wash before reuse. 		It classified into Category 2 according to description which stimulated person's skin and caused dermatitis (IARC Vol.8 (1975), HSDB (Access on May 2005), HSFS (2003), and SITTIG (4th, 2002)).
3 Serious eye damage/eye irritation Category 2A-2B Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection. 		We classified it as Category 2A-2B based on the description that it stimulates the eyes (ICSC (E) (2005)).
4 Respiratory sensitization Classification not possible - - - - No data
4 Skin sensitization Classification not possible - - - - There is a description that contact dermatitis was acknowledged in occupational exposure cases (IARC Vol.8 (1975)), however, details, such as number of cases, are unknown, moreover, since there is no information of reliable test data etc otherwise, we could not classify it.
5 Germ cell mutagenicity Category 2 Warning H341: Suspected of causing genetic defects P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		There are negative and positive results with in vivo mouse mutagenicity test using the somatic cells (micronucleus test) and positive with the test on rat liver/peripheral blood. Moreover, the positive results was obtained with genotoxicity tests (sister chromatid exchange test, DNA adduct formations test and DNA damage test) (all in RTECS(s) (Access on July 2005)). So it was classified as Category 2.
6 Carcinogenicity Category 2 Warning H351: Suspected of causing cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Since it is classified into group 2B in IARC 8 (1975) and Japan Assoc. of Industrial Health (2005) and R in NTP RoC (11th, 2005), it was considered as Category 2.
7 Reproductive toxicity Classification not possible - - - - There is a description that effect on spermatogenesis (intraperitoneal injection, RTECS(Access on July 2005), a musculoskeletal systems developmental defects (specific developmental abnormalities; musculoskeletal system. subcutaneous administration, RTECS (Access on July 2005)), and the teratogenicity of the scaffold including a cleft palates (a embryotic term single dose, unidentified administration route, HSDB (Access on May 2005)) were observed in the mouse. However, each case does not have detailed information, such as the influence on maternal or the discovered abnormalities. Therefore, it is unclassifiable due to insufficient date.
8 Specific target organ toxicity - Single exposure Category 3 （Respiratory tract irritation） Warning H335: May cause respiratory irritation (respiratory tract irritation) P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P405: Store locked up.
P501: Dispose of contents/container to ... 		From description in ICSC (E) (2005) that the airway is stimulated, it was judged that there was airway stimulativeness and was set as Category 3.
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - Since data was insufficient, we could not classify it. We had the description that cell-mediated immunoreactive inhibition was observed in the rat (HSDB (Access on May 2005)), however, the details of influence to the immune systems are unknown, and since other related information could not be found, we could not judge whether the immune systems is affected.
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Classification not possible - - - - Insufficient data available.
11 Hazardous to the aquatic environment （Long-term） Classification not possible - - - - Classification not possible due to lack of data


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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