GHS Classification Result

Chemical Name：2,2'-[oxybis(methylene)]bisoxirane
CAS：2238-07-5

Result：
ID: 898
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Category 4 - Warning H227: Combustible liquid P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ... 		Flash point: >60degC and <=93degC
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Classification not possible - - - - No data available
9 Pyrophoric liquids Classification not possible - - - - No data available
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Organic compounds containing oxygen (but not chlorine and fluorine) chemically bonded only to carbon and hydrogen (but not to other elements).
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - No data available

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		Category 4 based on SPECIES: Rat; ENDPOINT: LD50; VALUE: :450mg/kg (ACGIH 7th, 2001; PATTY 4th, 1994) and 510mg/kg (PATTY 4th, 1994)
1 Acute toxicity （Dermal） Category 3 Danger H311: Toxic in contact with skin P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P322: Specific treatment （see ... on this label）.
P361: Remove/Take off immediately all contaminated clothing.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Rat LD50 value = 1000mg/kg (ACGIH 7th, 2001, PATTY 4th, 1994), and rabbit LD50 value = 1500mg/kg (ACGIH 7th, 2001, PATTY 4th, 1994). The lower value was adopted and it was set as Category 3.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Category 1 Danger H330: Fatal if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P284: Wear respiratory protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P320: Specific treatment is urgent （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on rat LC50 (8 hours) value: 68ppm (4-hour equivalent: 0.51mg/L) (ACGIH 7th, 2001, PATTY 4th, 1994), 0.51mg/L could be judged from vapor pressure as the steam with almost no mist. And it was classified by the ppm concentration standard. 0.51mg/L was converted to 96ppm with the conversion factor (1ppm = 5.32mg/m3), and it was classified as Category 1.
1 Acute toxicity （Inhalation: Dusts and mists） Category 4 Warning H332: Harmful if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell. 		Based on rate LC50 (4 hours) value: 200ppm (equivalent 1.06mg/L) (ACGIH 7th, 2001, PATTY 4th, 1994), it was set as Category 4.
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P362: Take off contaminated clothing and wash before reuse. 		It was set as Category 2 from descriptions that severe irritation which produced erythema, edema and eschar was acknowledged in the test using the rabbit (ACGIH (7th, 2001)), and that severe irritation and chemical burn were acknowledged when single time application was done in the rabbit skin (PATTY (4th, 1994)).
3 Serious eye damage/eye irritation Category 2A Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection. 		We classified it as Category 2A based on the descriptions that severe irritational property was acknowledged in the tests applied to the eyes of the animals (ACGIH (7th, 2001) and PATTY (4th, 1994)).
4 Respiratory sensitization Classification not possible - - - - No data
4 Skin sensitization Classification not possible - - - - There were descriptions that strong skin sensitization was acknowledged in the test using the guinea pigs in ACGIH (7th, 2001) and PATTY (4th, 1994), however, the test method was not clear, therefore we presupposed it not to be able to be classified for the insufficiency of data.
5 Germ cell mutagenicity Classification not possible - - - - Classification not possible due to lack of data
6 Carcinogenicity Not classified - - - - Not classified because of "A4" (ACGIH, 7th, 2001)
7 Reproductive toxicity Classification not possible - - - - Although the effect on the testes was observed in the repetitive inhalation exposure test using rat (ACGIH (7th, 2001)), and the 24-hour inhalation exposure test using a rabbit, there is no data of the examination which examined fertility, and it cannot be classified since data is insufficient.
8 Specific target organ toxicity - Single exposure Category 1 (testis, respiratory system, liver, kidney, adrenal gland) Danger H370: Causes damage to organs (testis, respiratory system, liver, kidney, adrenal gland) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		From description in PATTY (4th, 1994) that in the inhalation exposure test using rats, breathing difficulty, change in liver, kidney, and the adrenal gland were seen at the concentration of the guidance value range of Category 1, and description in ACGIH (7th, 2001) that testicular atrophy was seen at the concentration of the guidance value range of Category 1 in the inhalation exposure test using the rabbits. So it was set as Category 1 (testes, respiratory tracts, liver, kidney, adrenal gland) .
9 Specific target organ toxicity - Repeated exposure Category 1 (testis, blood), Category 2 (eye, immune system, kidney, adrenal gland) Danger
Warning 		H372: Cause damage to organs through prolonged or repeated exposure (testis, blood)
H373: May cause damage to organs through prolonged or repeated exposure (eye, immune system, kidney, adrenal gland) 		P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		Based on the description that the effects on the testes and on the blood was observed with the concentration of the guidance value range of Category 1in the inhalation exposure test using the rat (ACGIH (7th, 2001) and PATTY (4th, 1994)), and on the description that in the dermal administration test using the rat, the corneal opacity, and the effects on thymic, lymphs, kidney , testes, and the adrenal with the dose of the guidance value range of Category 2 (PATTY (4th, 1994)), it was classified to be Category 1 ( testes, blood) and Category 2 (eye, immune system, kidney, adrenal gland).
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Classification not possible - - - - No data available
11 Hazardous to the aquatic environment （Long-term） Classification not possible - - - - No data available.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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