GHS Classification Result
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
Reference：
Chemical Name：Ethane, 1,1'-thiobis[2-chloro-
CAS：505-60-2
Result：
| ID: | 901 |
| Classifier: | Inter-ministerial Committee on GHS |
| Year Classified: | FY2006 |
| Reference Manual: | GHS Classification Manual （10 Feb, 2006） |
PHYSICAL HAZARDS
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable | - | - | - | - | There are no chemical groups associated with explosive properties present in the molecules. |
| 2 | Flammable gases （including chemically unstable gases） | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products |
| 4 | Oxidizing gases | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 5 | Gases under pressure | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 6 | Flammable liquids | Not classified | - | - | - | - | Flash point: >93degC |
| 7 | Flammable solids | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 8 | Self-reactive substances and mixtures | Not applicable | - | - | - | - | There are no chemical groups associated with explosive or self-reactive properties present in the molecule. |
| 9 | Pyrophoric liquids | Classification not possible | - | - | - | - | No data available |
| 10 | Pyrophoric solids | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 11 | Self-heating substances and mixtures | Classification not possible | - | - | - | - | Test methods applicable to liquid substances are not available |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | - | The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
| 13 | Oxidizing liquids | Not applicable | - | - | - | - | Organic compounds containing chlorine (but not oxygen and fluorine) chemically bonded only to carbon and hydrogen (but not to other elements). |
| 14 | Oxidizing solids | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 15 | Organic peroxides | Not applicable | - | - | - | - | Containing no -0-0- structure |
| 16 | Corrosive to metals | Classification not possible | - | - | - | - | No data available |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Category 2 |
|
Danger | H300: Fatal if swallowed |
P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P330: Rinse mouth. P405: Store locked up. P501: Dispose of contents/container to ... |
SPECIES: Rat ENDPOINT: LD50 VALUE: 17mg/kg REFERENCE SOURCE: ATSDR (2003) |
| 1 | Acute toxicity （Dermal） | Category 1 |
|
Danger | H310: Fatal in contact with skin |
P302+P350: IF ON SKIN: Gently wash with plenty of soap and water. P262: Do not get in eyes, on skin, or on clothing. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P280: Wear protective gloves/protective clothing/eye protection/face protection. P310: Immediately call a POISON CENTER or doctor/physician. P322: Specific treatment （see ... on this label）. P361: Remove/Take off immediately all contaminated clothing. P363: Wash contaminated clothing before reuse. P405: Store locked up. P501: Dispose of contents/container to ... |
Rabbit LD50 value = 100mg/kg (DFGOT vol.4, 1992), and rat LD50 value = 18mg/kg (DFGOT vol.4, 1992) and 9mg/kg (DFGOT vol.4, 1992, ATSDR, 2003). The lower rat LD50 value was adopted and it was set as Category 1. |
| 1 | Acute toxicity （Inhalation: Gases） | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 1 | Acute toxicity （Inhalation: Vapours） | Classification not possible | - | - | - | - | No data available |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Classification not possible | - | - | - | - | No data available |
| 2 | Skin corrosion/irritation | Category 2 |
|
Warning | H315: Causes skin irritation |
P302+P352: IF ON SKIN: Wash with plenty of soap and water. P332+P313: If skin irritation occurs: Get medical advice/attention. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection. P321: Specific treatment （see ... on this label）. P362: Take off contaminated clothing and wash before reuse. |
It was set as Category 2 from description that edema of the skin and blister formation are seen by humans evidence of exposure (DFGOT (4 vol. 1992), ATSDR (2003)). |
| 3 | Serious eye damage/eye irritation | Category 2A |
|
Warning | H319: Causes serious eye irritation |
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313: If eye irritation persists: Get medical advice/attention. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection. |
We classified it as Category 2A based on the descriptions that damage on the eyes was acknowledged in human exposure examples (DFGOT (4 vol. 1992) and ATSDR (2003)). |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | - | No data available |
| 4 | Skin sensitization | Classification not possible | - | - | - | - | No data available |
| 5 | Germ cell mutagenicity | Category 1B |
|
Danger | H340: May cause genetic defects |
P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ... |
Since there is a positive result (DFGOT vol.4, 1992, IARC 9, 1975, ATSDR, 2003) by the dominant lethal test using a rat, it is set as Category 1B. |
| 6 | Carcinogenicity | Category 1A |
|
Danger | H350: May cause cancer |
P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ... |
It was classified into group 1(IARC Suppl.7, 1987) in IARC, 1 (industrial hygene academic society recommentation, 2005) in Japan Assoc. of Industrial Health, and K (NTP RoC 11th, 2005) in NTP. So it was considered as Category 1A. |
| 7 | Reproductive toxicity | Category 1B |
|
Danger | H360: May damage fertility or the unborn child |
P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ... |
It was considered as Category 1B based on the description that the male reproductive function effects are indicated in the study for the humans of ATSDR (2003). |
| 8 | Specific target organ toxicity - Single exposure | Category 1 (systemic toxicity) |
|
Danger | H370: Causes damage to organs (systemic toxicity) |
P307+P311: IF exposed: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ... |
Although it is described in ATSDR (2003) that the target organs in acute exposure, in human exposures, are skin, eyes and airways, DFGOT (vol.4, 1992) has description that affect is seen in various organs, such as a brain, bone marrow, blood, an alimentary canal, and kidney, by enzyme inhibition. Since target organ could not be specified, it was set as Category 1 (systemic toxicity). |
| 9 | Specific target organ toxicity - Repeated exposure | Category 1 (respiratory system) |
|
Danger | H372: Cause damage to organs through prolonged or repeated exposure (respiratory system) |
P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ... |
We classified it to be Category 1 (respiratory tracts) based on the description that the impact on respiratory tracts is observed in occupational exposure examples (DFGOT (vol.4, 1992)). |
| 10 | Aspiration hazard | Classification not possible | - | - | - | - | No data available |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Classification not possible | - | - | - | - | Insufficient data available. |
| 11 | Hazardous to the aquatic environment （Long-term） | Classification not possible | - | - | - | - | Classification not possible due to lack of data |
NOTE:
|
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference：
|
Reference Manual |
|
|
Definitions / Abbreviations |
|
|
Model Label by MHLW |
MHLW Website （in Japanese Only） |
|
Model SDS by MHLW |
MHLW Website （in Japanese Only） |