GHS Classification Result

Chemical Name：1-Butanol
CAS：71-36-3

Result：
ID: 912
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Category 3 Warning H226: Flammable liquid and vapour P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P233: Keep container tightly closed.
P240: Ground/bond container and receiving equipment.
P241: Use explosion-proof electrical/ventilating/lighting/.../equipment.
P242: Use only non-sparking tools.
P243: Take precautionary measures against static discharge.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ... 		Flash point: >=23degC and <=60degC, UNRTDG Class: 3, PGIII
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not classified - - - - Flash point: 343degC (NFPA (12th, 1997) p325-20)
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Not classified - - - - UNRTDG Class: 3
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Organic compounds containing oxygen (but not chlorine and fluorine) chemically bonded only to carbon and hydrogen (but not to other elements).
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Containing no -0-0- structure
16 Corrosive to metals Not classified - - - - UNRTDG Class: 3

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		Calculated based on the following values: Rat LD50 value = 790mg/kg ((3rd volume of MOE Risk Assessment (2004), SIDS (2004), EHC 65 (1987)), 4360mg/kg ((SIDS (2004), ACGIH (2002), PATTY (4th, 1994)), 2290mg/kg (SIDS (2004)), 2510mg/kg (SIDS (2004), ACGIH (2002), PATTY (4th, 1994)), 2100mg/kg (EHC 65 (1987), DFGOT vol.19 (2003)), and 700mg/kg (EHC 65 (1987), DFGOT vol.19 (2003)). Since the calculated values was 1227mg/kg, it was classified to category 4.
1 Acute toxicity （Dermal） Category 5 - Warning H313: May be harmful in contact with skin P312: Call a POISON CENTER or doctor/physician if you feel unwell. Calculated based on rabbit LD50 value = 3402mg/kg (SIDS (2004), DFGOT vol.19 (2003)), 5300mg/kg (SIDS (2004), EHC 65 (1987), ACGIH (2002), DFGOT vol.19 (2003), PATTY (4th, 1994)), and 4200mg/kg (EHC 65 (1987), PATTY (4th, 1994)). Since the calculated values was 3636mg/kg, it was set as Category 5.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Not classified - - - - There are description that death was not observed on rats with 4-hour exposure to 8000ppm (equivalent: 24.2mg/L) (SIDS (2004), EHC 65 (1987), ACGIH (2002), DFGOT vol.19 (2003) and PATTY (4th, 1994)), it was classified as out of Category. 24.2mg/L suggests that mist is intermingled from vapor pressure.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P362: Take off contaminated clothing and wash before reuse. 		From description that the moderate irritation was acknowledged by 24-hour patch test using the rabbit (SIDS (2004), EHC 65 (1987), DFGOT vol.19 (2003)), and from description that dermatitis was acknowledged in employment evidence of exposure (SIDS (2004), ACGIH (2002), DFGOT vol.19 (2003)), it was set as Category 2.
3 Serious eye damage/eye irritation Category 2A Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection. 		The middle to severe stimulativeness was acknowledged by the test using the rabbits and it did not recover within seven days, but it recovered completely within 21 days (ECETOC TR 48 (1992)). Therefore we classified it as Category 2A. We found the descriptions that eye irritational property, such as keratoconjunctivitis, was acknowledged also by occupational exposure (exposure to vapor) in human cases (MOE Risk Assessment The 3rd volume (2004), SIDS (2004), EHC 65 (1987), ACGIH (2002), DFGOT vol.19 (2003), and Japan Society for Occupational Health Recommendation of Occupational Exposure Limits (1993)).
4 Respiratory sensitization Classification not possible - - - - Classification not possible due to lack of data
4 Skin sensitization Classification not possible - - - - Classification not possible due to lack of data
5 Germ cell mutagenicity Not classified - - - - Since there was a negative result (SIDS (2004), ACGIH (2002)) by the micronucleus test with the mammalian erythrocyte , which is an in vivo mutagenicity tests using a somatic, it carried out the outside of Category.
6 Carcinogenicity Not classified - - - - Since it was classified into D in EPA, it was considered as the outside of Category.
7 Reproductive toxicity Not classified - - - - It is considered as out of Category according to the guideline since only the frame variation (cervical rib) in a fetus was observed at the exposure concentrations in which dam toxicity is observed in the inhalation exposure test to the pregnant rats (MOE Risk Assessment the 3rd volume (2004), SIDS (2004), ACGIH (2002), DFGOT vol.19 (2003), and PATTY (4th, 1994)).
8 Specific target organ toxicity - Single exposure Category 3 （Respiratory tract irritation, Narcotic effects） Warning H335: May cause respiratory irritation (respiratory tract irritation, narcotic effects)
H336: May cause drowsiness or dizziness (respiratory tract irritation, narcotic effects) 		P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P405: Store locked up.
P501: Dispose of contents/container to ... 		From description in MOE Risk Assessment the 3rd volume (2004) and DFGOT vol.19 (2003) that the slight stimulus was seen in human pharynx in inhalation exposure, it was considered to be respiratory irritant and was set as Category 3. Moreover, from description in SIDS (2004), EHC 65 (1987), ACGIH (2002), DFGOT vol.19 (2003) and PATTY (4th, 1994) that anesthetic actions or central nervous system depression was seen in animal experiments, and from description in MOE Risk Assessment the 3rd volume (2004) and DFGOT vol.19 (2003) that headache was seen in human inhalation exposure, it was thought that there was an anesthetic actions and was set as Category 3.
9 Specific target organ toxicity - Repeated exposure Category 1 (central nervous system, auditory organ) Danger H372: Cause damage to organs through prolonged or repeated exposure (central nervous system, auditory organ) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		Based on the descriptions that dizziness and headache were observed in human occupational exposure examples ( MOE Risk Assessment The 3rd volume (2004), EHC 65 (1987), ACGIH (2002), DFGOT vol.19 (2003), PATTY (4th, 1994) and Japan Society for Occupational Health advice (1993)), and based on the descriptions that hearing loss was observed in human occupational exposure examples (EHC 65 (1987), DFGOT vol.19 (2003),PATTY (4th, 1994) and Japan Society for Occupational Health advice (1993)), the central nervous system and the auditory organ were considered to be target organ, and we categorized both of them as Category 1.
10 Aspiration hazard Category 2 Warning H305: May be harmful if swallowed and enters airways P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P331: Do NOT induce vomiting.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Category 2 because of being a primary normal alcohol composed of carbon atoms (3<=n>=13) and containing an isobutyl alcohol and ketone composed of carbon atoms (n>=13).

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Not classified - - - - It carried out the outside of Category from 96-hour LC50>100mg/L of fishes (Oryzias latipes) (MOE eco-toxicity tests of chemicals, 1996).
11 Hazardous to the aquatic environment （Long-term） Not classified - - - - Since not water-insoluble (aqueous solubility =63200mg/L(PHYSPROP Database, 2005)) and acute toxicity is low.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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