GHS Classification Result

Chemical Name:Diethylphthalate
CAS:84-66-2

Result:
ID: 916
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual (10 Feb, 2006)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Not classified - - - - Flash point: >93degC
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not classified - - - - Flash point: 457degC (ICSC (J), 2001)
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Organic compounds containing oxygen (but not chlorine and fluorine) chemically bonded only to carbon and hydrogen (but not to other elements).
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - No data available

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Not classified - - - - Rat LD50 value: 8600mg/kg (MOE Risk Assessment the 3rd volume (2004), NTP TR429 (1995)), 9200 - 9500mg/kg (CICAD 52 (2003)) and 9500 - 31000mg/kg (ACGIH 7th (2001), Advice of Sanei Society (1995)). Based on the values above, it was considered as out of category.
1 Acute toxicity (Dermal) Not classified - - - - Based on rat LD50 value: >22400mg/kg and >11200mg/kg (IUCLID, 2000), it was set as the outside of Category.
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available
1 Acute toxicity (Inhalation: Dusts and mists) Not classified - - - - From description that death was not acknowledged in the test using the rat (PATTY 4th (1994)) by 511ppm of 6-hour exposure (4-hour equivalent 6.95mg/L), it was set as the outside of Category.
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment (see ... on this label).
P362: Take off contaminated clothing and wash before reuse.
There is description that human skin is not stimulated (NTP TR429 (1995) and PATTY (4th, 1994)), and that the irritation in the examination which used the animal is slight (NTP TR429 (1995), ATSDR (1995), and PATTY (4th, 1994)). But also there is description that irritation was admitted in 2 examples among 143 examples by the patch test for the humans (the 3rd volume of MOE Risk Assessment (2004) and CICAD 52 (2003)), and that dermatitis and eczema were admitted by adhesion on the skin (the 3rd volume of MOE Risk Assessment (2004) and Occupational Health Recommendation of Occupational Exposure Limits (1995)). So it was judged that there was skin irritation in some humans, and it was set as Category 2.
3 Serious eye damage/eye irritation Category 2B - Warning H320: Causes eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
We found a description that it had no irritant property in the test applied to the eyes of the rabbits (CICAD 52 (2003)), and a description that very slight irritation was acknowledged in the eyes of the rabbits (CICAD 52 (2003) and ATSDR (1995)). However, we found a description that it stimulated the eyes of the rabbits slightly and it stimulated the human eyes (NTP TR429 (1995)). Therefore we classified it as Category 2B.
4 Respiratory sensitization Classification not possible - - - - No data
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment (see ... on this label).
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ...
We found the description that sensitizing property was not acknowledged in Buehler test which used the guinea pigs, Draize test, Freund's complete adjuvant test, maximization test and open epicutaneous test in IUCLID (2000) or BUA 104 (1994), and we found the description that the allergic reactions was not acknowledged by the patch test for human in MOE Risk Assessment The 3rd volume (2004), CICAD 52 (2003), ATSDR (1995) and it is enrolled in PATTY (4th, 1994) that it has no sensitizing property, however, according to the descriptions of MOE Risk Assessment the 3rd volume (2004), CICAD 52 (2003), and ATSDR (1995), the allergic reactions was acknowledged by one example respectively in patch tests in different institutions, therefore we classified it as 1.
5 Germ cell mutagenicity Classification not possible - - - - Classification not possible due to lack of data
6 Carcinogenicity Not classified - - - - Since it was classified into A4 (ACGIH 7th, 2001) in ACGIH and D (IRIS, 2005)in EPA, it was considered as the outside of Category.
7 Reproductive toxicity Not classified - - - - It was considered as out of category based on the description that specific reproductive toxicity was not observed at the dose in which general toxicity is observed in parental animals in an oral administration examination during the pregnancy and a two-generation reproductive study using the rat and mouse (MOE Risk Assessment the 3rd volume (2004), CICAD 52 (2003), ACGIH (7th, 2001), NTP TR429 (1995), industrial hygene academic recommendation (1995) and ATSDR (1995)).
8 Specific target organ toxicity - Single exposure Category 3 (Respiratory tract irritation, Narcotic effects) Warning H335: May cause respiratory irritation (respiratory tract irritation, narcotic effects)
H336: May cause drowsiness or dizziness (respiratory tract irritation, narcotic effects)
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P405: Store locked up.
P501: Dispose of contents/container to ...
From description in MOE Risk Assessment the 3rd volume (2004), ACGIH (7th, 2001), Society for Occupational Health Recommendation of Occupational Exposure (1995) and PATTY (4th, 1994) that vapor stimulates respiratory tracts, description in MOE Risk Assessment the 3rd volume (2004) that when inhaling, giddiness and hypesthesia will be caused, and description in PATTY (4th, 1994) that the central nervous system may be restrained. So it was set as Category 3 (respiratory irritation, anesthesia action).
9 Specific target organ toxicity - Repeated exposure Not classified - - - - It was considered to be the Out Of Category based on the descriptions that toxic effects were not observed for the high doses which exceeds the guidance value range of Category 2 in oral or the dermal administration tests using the rat or mouse (MOE Risk Assessment 3rd volume (2004), CICAD 52 (2003), ACGIH (7th, 2001), NTP TR429 (1995), ATSDR (1995), and IRIS (2005)).
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 2 - - H401: Toxic to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ...
It was classified into Category 2 from 96-hour LC50=1200microg/L of fishes (Rainbow trout) (MOE Risk Assessment No.3, 2004).
11 Hazardous to the aquatic environment (Long-term) Not classified - - - - Since rapidly degrading (BOD: 88% (existing chemical safety inspections data)), and less bio-accumulative (log Kow=2.42 (PHYSPROP Database, 2005)).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model SDS by MHLW

MHLW Website (in Japanese Only)


To GHS Information