GHS Classification Result

Chemical Name：1-Propanol
CAS：71-23-8

Result：
ID: 927
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Classification not possible (Category 2 or Category 3) Danger H225: Highly flammable liquid and vapour P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P233: Keep container tightly closed.
P240: Ground/bond container and receiving equipment.
P241: Use explosion-proof electrical/ventilating/lighting/.../equipment.
P242: Use only non-sparking tools.
P243: Take precautionary measures against static discharge.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ... 		The data obtained from materials are distributed in two Categories. Therefore, if the flash point is not measured with a real sample, it cannot be judged. The acceptance criteria are as follows: (The initial boiling point is substituted with boiling point). Category 2: flash point <23 degC; Category 3: 23 degC<= flash point <=60 degC
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not classified - - - - Flash point: 371degC (ICSC (J), 1999)
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Organic compounds containing oxygen (but not chlorine and fluorine) chemically bonded only to carbon and hydrogen (but not to other elements).
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Containing no -0-0- structure
16 Corrosive to metals Not classified - - - - UNRTDG Class: 3

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 5 - Warning H303: May be harmful if swallowed P312: Call a POISON CENTER or doctor/physician if you feel unwell. Calculated based on the following values: Rat LD50 value: 1900mg/kg (ACGIH, 2004), 1870mg/kg (PATTY 4th, 1994, EHC 102, 1990), 5400mg/kg (PATTY 4th, 1994) and 6500mg/kg (PATTY 4th, 1994, EHC 102, 1990). Since the calculated values was 2695mg/kg, it was classified to category 5.
1 Acute toxicity （Dermal） Category 5 - Warning H313: May be harmful in contact with skin P312: Call a POISON CENTER or doctor/physician if you feel unwell. Calculated based on rabbit LD50 value: 6700mg/kg (PATTY 4th, 1994, ACGIH, 2004), 4060mg/kg (ACGIH, 2004), 4000mg/kg (PATTY 4th, 1994), and 4050mg/kg (EHC 102, 1990). Since the calculated values was 4031mg/kg, it was set as Category 5.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - There are descriptions that death was not observed in rat 1-hour exposure with 20000 ppm (4 hour equivalent: 24.531mg/L) (PATTY (4th, 1994)) and that 2 of 6 rats died with 4-hour exposure to 4000 ppm (9.84mg/L) (EHC 102 (1990) and PATTY (4th, 1994)). But LC50 value was not indicated, it cannot be classified due to data insufficiency.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P362: Take off contaminated clothing and wash before reuse. 		There is possibility of Category 3 from description that the skin of the rabbit was stimulated very slightly (PATTY (4th, 1994)). But it was set as Category 2 from description that erythema was accepted by 9 among 12 examples in the test applied to the skin of the humans (EHC 102 (1990)).
3 Serious eye damage/eye irritation Category 2A Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection. 		We classified it as Category 2A based on the descriptions that severe conjunctivitis, iritis, corneal opacity and ulcerations were acknowledged in the test applied to the eyes of the rabbits (ACGIH (2004) and PATTY (4th, 1994)).
4 Respiratory sensitization Classification not possible - - - - No data
4 Skin sensitization Classification not possible - - - - Although we found description of one case report in which the allergic response was acknowledged by the patch test in EHC 102 (1990), there was no other data and we presupposed that we could not classify it since data was insufficient.
5 Germ cell mutagenicity Classification not possible - - - - Classification not possible due to lack of data
6 Carcinogenicity Category 2 Warning H351: Suspected of causing cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Category 2 based on "A3" (ACGIH, 2004)
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		It was considered as Category 2. Based on the description that malformation increases was observed at the dose in which general toxicity is observed in the dam animals in the test which carried out inhalation exposure in the rat pregnant (ACGIH (2004), PATTY (4th, 1994)), and the description that the male reproduction ability fall and the deformed (crooked tail) increase in a child were observed at the dose in which general toxicity is observed in the inhalation exposure test using the male and female rats (ACGIH (2004), PATTY (4th, 1994), EHC 102 (1990)).
8 Specific target organ toxicity - Single exposure Category 3 （Narcotic effects, Respiratory tract irritation） Warning H335: May cause respiratory irritation (narcotic effects, respiratory tract irritation)
H336: May cause drowsiness or dizziness (narcotic effects, respiratory tract irritation) 		P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Because of descriptions in ACGIH (2004), EHC 102 (1990), and PATTY (4th, 1994) referring to the confirmation of anesthetic actions in inhalation exposure or oral administration examinations using rats, mice and rabbits, and of a description in EHC 102 (1990) referring to that a reduction of breathing rates indicating respiratory irritant was confirmed in an inhalation exposure test using mice, it was judged as Category 3 (anesthetic actions, respiratory irritant).
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - Classification not possible due to lack of data
10 Aspiration hazard Category 2 Warning H305: May be harmful if swallowed and enters airways P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P331: Do NOT induce vomiting.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Category 2 because of being a primary normal alcohol composed of carbon atoms (3<=n>=13).

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Not classified - - - - It carried out the outside of Category from 48-hour LC50=3025mg/L of Crustacea (Water flea) (EHC102, 1990).
11 Hazardous to the aquatic environment （Long-term） Not classified - - - - Since not water-insoluble (water solubility=1.00*106mg/L(PHYSPROP Database, 2005)) and acute toxicity is low.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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