GHS Classification Result

Chemical Name：bromacil
CAS：314-40-9

Result：
ID: 935
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Not classified - - - - Non-combustible (ICSC (J) (2003))
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - Non-combustible (ICSC (J), 2003)
11 Self-heating substances and mixtures Not classified - - - - Not combustible (ICSC(J) (2003))
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not applicable - - - - Organic compounds containing oxygen (but not chlorine and fluorine) and the oxygen is chemically bonded only to carbon and hydrogen (but not to other elements).
15 Organic peroxides Not applicable - - - - Containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - Liquid at a test temperature, 55degC. Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		SPECIES: Rat (female) ENDPOINT: LD50 VALUE: 691 mg/kg REFERENCE SOURCE: Agricultural Chemicals abstracts
1 Acute toxicity （Dermal） Not classified - - - - It was set as the outside of Category. Since rat LD50 value is >2000mg/kg and death is not observed at 2000mg/kg (Agricultural-Chemicals abstracts).
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Solid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - Rat LC50 (4 hours) value is >4.2mg/L (Agricultural-Chemicals abstracts). But the category could not be specified only by this data, it cannot be classified since data is insufficient.
2 Skin corrosion/irritation Category 3 - Warning H316: Causes mild skin irritation P332+P313: If skin irritation occurs: Get medical advice/attention. In the skin irritation test using a guinea pigs, it was the effects of exposure, mild irritation was seen for 24 hours (Agricultural -Chemicals abstracts). So it was set as Category 3.
3 Serious eye damage/eye irritation Category 2B - Warning H320: Causes eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling. 		The moderate irritant property was seen in the ocular irritation tests using the rabbits. However, the symptom disappeared after 7 days after administration (Agrichemical-Chemicals abstracts), therefore we classified it as Category 2B.
4 Respiratory sensitization Classification not possible - - - - No data
4 Skin sensitization Not classified - - - - Since positive rate was 0% in the Buehler method test using the guinea pigs (Agrichemical Abstracts), we classified it to be Out Of Category.
5 Germ cell mutagenicity Not classified - - - - There is a negative result in the micronucleus test which used the mouse marrow, which is an in vivo mutagenicity test using a somatic (Agricultural-Chemicals abstracts). So it considered as the outside of Category.
6 Carcinogenicity Category 2 Warning H351: Suspected of causing cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Since it was classified into A3 (ACGIH 7th, 2001) in ACGIH, it was considered as Category 2.
7 Reproductive toxicity Not classified - - - - In the teratogenicity study using rats and rabbits, reproductive toxicity was not observed at the dose in which general toxicity is observed in parent animals (Agricaltural-Chemicals abstracts). Therefore, it was out of the Category. Moreover, although it is an examination at the dose in which general toxicity is not observed in a parental animals, the effects on fertility is not observed in the reproduction study using a rat (Agricaltural-Chemicals abstracts).
8 Specific target organ toxicity - Single exposure Category 3 （Narcotic effects） Warning H336: May cause drowsiness or dizziness (narcotic effects) P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Because of confirmation of sedation and comas in an oral administration study using rats, and confirmation of immediate lethargy after in a inhalation exposure test (Agricultural-Chemical abstracts), it was judged as Category 3 (anesthetic actions).
9 Specific target organ toxicity - Repeated exposure Not classified - - - - In the repeated oral administration test using rats and dogs, toxicity was not observed with the dose of the guidance value range of Category 2, and since the significant toxicity which indicates the classification also with the dose exceeding the guidance value of Category 2 in the rats (feeding administration for 90 days) was not observed (Agrichemical Abstracts), it was judged to be Out Of Category.
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		It was classified into Category 1 from 72-hour EbC50=0.00844mg/L of algae (Green algae) (Agricultural Chemical Registration Data, 2005).
11 Hazardous to the aquatic environment （Long-term） Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Classified into Category 1, since acute toxicity was Category 1, supposed not rapidly degrading (BIOWIN), though supposed less bioaccumulative (log Kow=2.11 (PHYSPROP Database, 2005)).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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