GHS Classification Result

Chemical Name：Ethane, hexachloro-
CAS：67-72-1

Result：
ID: 936
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Not classified - - - - Non-combustible (ICSC (J), 1993; etc.)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - Non-combustible (ICSC (J), 1993; etc.)
11 Self-heating substances and mixtures Not classified - - - - Non-combustible (ICSC(J) (1993); etc)
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not applicable - - - - Organic compounds containing chlorine (but not oxygen and fluorine) and the chlorine is chemically bonded only to carbon and hydrogen (but not to other elements).
15 Organic peroxides Not applicable - - - - Containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - Although a potential of corroding iron is suggested (ICSC (J) (1993)), test methods suitable for a solids material are not established.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 5 - Warning H303: May be harmful if swallowed P312: Call a POISON CENTER or doctor/physician if you feel unwell. Rat LD50 value: 4460mg/kg (ACGIH 7th (2001), PATTY 4th (1994), ATSDR (1997), NTP TR361(1989)), 7080mg/kg (PATTY 4th (1994), ATSDR (1997), NTP TR361 (1989)), 5900mg/kg (PATTY 4th (1994), NTP TR361 (1989)), 4489mg/kg (ATSDR (1997)) and 6000mg/kg (NTP TR361 (1989)). calculated based on the values above. Since the calculated values was 4767mg/kg, it was classified to category 5.
1 Acute toxicity （Dermal） Not classified - - - - Based on rabbit LD50 values: 32000mg/kg or >32000mg/kg (ACGIH 7th, 2001, PATTY 4th, 1994, NTP TR361, 1989, ATSDR, 1997), it was set as the outside of Category.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Solid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Dusts and mists） Not classified - - - - LC50 value was not indicated from description that two examples died among six examples in the test using the rat by 5900ppm 8-hour exposure (4-hour equivalent 114 mg/L) (IARC 73 (1999), ATSDR (1997)). But lethal concentration was over 20 times of the limit of 4. Therefore, it was judged as the outside of category.
2 Skin corrosion/irritation Category 3 - Warning H316: Causes mild skin irritation P332+P313: If skin irritation occurs: Get medical advice/attention. There is description that irritation was not acknowledged in the test applied to the skin of the rabbit (PATTY (4th, 1994), NTP TR361 (1989), and ATSDR (1997)). But it was set as Category 3 from description that slight skin irritation was acknowledged in the example of repetitive exposure of the humans (IARC 73 (1999), ATSDR (1997)).
3 Serious eye damage/eye irritation Category 2B - Warning H320: Causes eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling. 		There is the descriptions that in the test applied to the eyes of the rabbit, the ocular irritant property which recovered 72 hours after administration was acknowledged (PATTY (4th, 1994), NTP TR361 (1989) and ATSDR (1997)). Therefore we judged that ocular irritant property was slight and classified it as Category 2B.
4 Respiratory sensitization Classification not possible - - - - No data
4 Skin sensitization Not classified - - - - Based on the description that sensitizing property was not acknowledged in the skin sensitivity test using the guinea pigs in ACGIH (7th, 2001), PATTY (4th, 1994), NTP TR361 (1989) and ATSDR (1997), we classified it to be Out Of Category.
5 Germ cell mutagenicity Classification not possible - - - - Although there is a positive result (IARC 73, 1999) in a joint examination with somatic DNA of a rat and a mouse which is an in vivo genotoxicity study using a somatic, there is no positive result by in vitro mutagenicity test. So it cannot classify
6 Carcinogenicity Category 2 Warning H351: Suspected of causing cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		It was classified into C (IRIS, 2006) in EPA in 1994. But it was classified in group 2B (IARC 73, 1999) in IARC, A3 (ACGIH 7th, 2001) in ACGIH, and R (NTP RoC 11th, 2005) in NTP. So it was considered as Category 2 according to ACGIH which is latest assessment document.
7 Reproductive toxicity Not classified - - - - It was considered as out of Category based on the description that specific reproductive toxicity was not observed at the dose in which general toxicity is observed in a dam animals in oral administration and an inhalation exposure test using pregnancy rat (ACGIH (7th, 2001), PATTY (4th, 1994), IARC 73 (1999), IRIS (2006), ATSDR (1997), NTP TR361 (1989)).
8 Specific target organ toxicity - Single exposure Classification not possible - - - - Insufficient data available.
9 Specific target organ toxicity - Repeated exposure Category 2 (kidney, nervous system) Warning H373: May cause damage to organs through prolonged or repeated exposure (kidney, nervous system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		Based on the description that the influence on the kidney was observed among male and females with the dose of the guidance value range of Category 2 in the oral study using the rats (ACGIH (7th, 2001), PATTY (4th, 1994), IARC 73 (1999), NTP TR361 (1989), IRIS (2006), ATSDR (1997)), and based on the description that the effects on the nervous system was observed with the concentration of the guidance value range of Category 2 in the inhalation exposure test using the dogs (ACGIH (7th, 2001), IARC 73 (1999), NTP TR361 (1989), IRIS (2006), and ATSDR (1997)), we cateforized it as Category 2 (the kidney, nervous system).
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		It was classified into Category 1 from 96-hour LC50=0.97mg/L of fishes (Bluegill) (ECETOC TR91, 2003).
11 Hazardous to the aquatic environment （Long-term） Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Classified into Category 1, Classified into Category 1, since acute toxicity was Category 1, and not rapidly degrading (BOD: 0% (existing chemical safety inspections data)), though less bio-accumulative (BCF=8.5 (existing chemical safety inspections data)).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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