GHS Classification Result

Chemical Name：1-Hexene
CAS：592-41-6

Result：
ID: 942
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Category 2 Danger H225: Highly flammable liquid and vapour P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P233: Keep container tightly closed.
P240: Ground/bond container and receiving equipment.
P241: Use explosion-proof electrical/ventilating/lighting/.../equipment.
P242: Use only non-sparking tools.
P243: Take precautionary measures against static discharge.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ... 		Flash point: <23degC, Initial boiling point: >35degC, UNRTDG Class: 3, PG II
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not classified - - - - Classified in UNRTDG Class: 3
9 Pyrophoric liquids Not classified - - - - Flash point: 253degC (ICSC (J), 1990)
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Organic compounds containing no oxygen, fluorine and chlorine.
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Containing no -0-0- structure
16 Corrosive to metals Not classified - - - - UNRTDG Class: 3

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Not classified - - - - SPECIES: Rat ENDPOINT: LD50 VALUE: > 5600 mg/kg REFERENCE SOURCE: SIDS (2000), ACGIH (2002)
1 Acute toxicity （Dermal） Not classified - - - - From the description that death was not observed at 2000mg/kg in the test using rabbits (SIDS (2000), ACGIH (2002)), it was set as the outside of Category.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Not classified - - - - Based on rat LC50 (4 hours) value: 32000ppm (equivalent: 109.92mg/L), which vapor pressure indicate steam with almost no mist. It was classified as out of Category by the ppm concentration standard.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available
2 Skin corrosion/irritation Not classified - - - - From description that the average Draize scores was 0-1.0 in the skin irritation test using the rabbit (SIDS (2000) and ACGIH (2002)), it was judged that there was no irritation and was carried out the outside of Category.
3 Serious eye damage/eye irritation Not classified - - - - Since change of the eyes which corresponded to the standard of irritant property was not acknowledged in the ocular irritation tests using the rabbits (SIDS (2000) and ACGIH (2002)), we classified it as Out Of Category.
4 Respiratory sensitization Classification not possible - - - - No data
4 Skin sensitization Not classified - - - - Based on the description that sensitizing property was not acknowledged in Buehler test using the guinea pigs of SIDS (2000), and the description that in the test using the guinea pigs of ACGIH (2002) sensitizing property was not acknowledged, we categorized it as Out Of Category.
5 Germ cell mutagenicity Not classified - - - - There is a negative result (SIDS, 2000; ACGIH, 2002) by the micronucleus test using the mouse erythrocyte, which is an in vivo mutagenicity test using a a somatic. So it carried out the outside of Category.
6 Carcinogenicity Classification not possible - - - - No data available
7 Reproductive toxicity Not classified - - - - It was considered as out of Category based on the description that reproduction toxicity was not observed at a 1000mg/kg high dose in the reproductive examination in the oral administration using rat (SIDS (2000), ACGIH (2002)).
8 Specific target organ toxicity - Single exposure Category 3 （Narcotic effects, Respiratory tract irritation） Warning H336: May cause drowsiness or dizziness (narcotic effects, respiratory tract irritation)
H335: May cause respiratory irritation (narcotic effects, respiratory tract irritation) 		P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Because of descriptions in SIDS (2000), ACGIH (2002), and PATTY (4th, 1994) referring to confirmation of central nervous system depressions, dizziness, nausea, cyanosis, and mucosal irritation through inhalation exposure to humans, they were judged as transient conditions which all has recovery properties, and determined to be Category 3 (anesthetic actions, respiratory irritant).
9 Specific target organ toxicity - Repeated exposure Not classified - - - - The toxicity was not acknowledged with the dosage of the guidance value range of Category 2 in the repeated oral administration test using the rat (SIDS, 2000), and in the 90-day inhalation exposure test using the rat (SIDS, 2000, ACGIH, 2002), therefore we categorized it as Out Of Category.
10 Aspiration hazard Category 1 Danger H304: May be fatal if swallowed and enters airways P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P331: Do NOT induce vomiting.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Category 1 because of a hydrocarbon and the dynamic viscosity: 0.39mm2/s at 25degC.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 2 - - H401: Toxic to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		It was classified into Category 2 from 96-hour LC50=5.6mg/L of fishes (Rainbow trout) (SIDS, 2004).
11 Hazardous to the aquatic environment （Long-term） Not classified - - - - Since rapidly degrading (BOD: 77% (existing chemical safety inspections data)), and less bio-accumulative (log Kow=3.39 (PHYSPROP Database, 2005)).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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