GHS Classification Result

Chemical Name：Disodium peroxydisulfate
CAS：7775-27-1

Result：
ID: 949
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not classified - - - - UNRTDG Class: 5.1
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Not classified - - - - Non-combustible (ICSC (J) (2002))
8 Self-reactive substances and mixtures Not applicable - - - - Classified in oxidizing solids
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - Non-combustible (ICSC (J), 2002)
11 Self-heating substances and mixtures Not classified - - - - Not combustible (ICSC(J) (2002))
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified - - - - UNRTDG Class: 5.1
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Category 3 Warning H272: May intensity fire; oxidizer P370+P378: In case of fire: Use ... for extinction.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P220: Keep/Store away from clothing/.../combustible materials.
P221: Take any precaution to avoid mixing with combustibles/...
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ... 		UNRTDG Class: 5.1; PG III
15 Organic peroxides Not applicable - - - - Inorganic substance
16 Corrosive to metals Classification not possible - - - - There is no data including the melting point data used as the judgment material of examination propriety.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		Category 4 based on SPECIES: Rat; ENDPOINT: LD50; VALUE: :920mg/kg and 895mg/kg; REFERENCE SOURCE: NICNAS (2001)
1 Acute toxicity （Dermal） Not classified - - - - Based on rabbit LD50 value: >10000mg/kg (NICNAS, 2001), it was set as the outside of Category.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Solid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Dusts and mists） Not classified - - - - Based on rat LC50 (4 hours) value : >5.1mg/L and >21.6mg/L (NICNAS, 2001), LC50 (1 hour) value: >191.7mg/L (4-hour equivalent >47.93mg/L) (NICNAS, 2001), it was set as the outside of Category.
2 Skin corrosion/irritation Category 3 - Warning H316: Causes mild skin irritation P332+P313: If skin irritation occurs: Get medical advice/attention. From description that the skin was stimulated (ICSC (J), (2002), and HSFS (1999)), and description that mild irritation was admitted in the test applied to the skin of the rabbit (NICNAS (2001)), it was judged that irritation was slight and was set as Category 3.
3 Serious eye damage/eye irritation Category 2B - Warning H320: Causes eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling. 		We thought that it was incompatible for the acceptance criteria of irritation based on the description that only mild conjunctivitis was acknowledged in the test applied to the eyes of the rabbits (NICNAS (2001)). However, we found the descriptions that it stimulated the eyes (ICSC (J), (2002) and HSFS (1999)). Therefore we judged that it had mild ocular irritant property and classified it as Category 2B.
4 Respiratory sensitization Category 1 Danger H334: May cause allergy or asthma symptoms or breathing difficulties if inhaled P304+P341: IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342+P311: If experiencing respiratory symptoms: Call a POISON CENTER or doctor/physician.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P285: In case of inadequate ventilation wear respiratory protection.
P501: Dispose of contents/container to ... 		There was a case report in NICNAS (2001) that asthma symptoms was induced by inhalation exposure in human, and in NICNAS (2001) it was concluded to be positive for respiratory sensitizing properties, therefore we classified it as Category 1.
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ... 		There were reports of two or more cases which gave the positive reaction by Patch test in NICNAS (2001), and it was concluded that the skin sensitizing was positive in NICNAS (2001), furthermore, we found the description that 30% or more indicated the positive in Optimization Test using the guinea pigs in NICNAS (2001), therefore we classified it to be Category 1.
5 Germ cell mutagenicity Not classified - - - - Although the performing sector was unknown, there was a negative result (NICNAS, 2001) in the micronucleus test which used the mouse, which is an in vivo mutagenicity test. So it carried out the outside of Category.
6 Carcinogenicity Classification not possible - - - - No data available
7 Reproductive toxicity Classification not possible - - - - No data available
8 Specific target organ toxicity - Single exposure Category 3 （Respiratory tract irritation） Warning H335: May cause respiratory irritation (respiratory tract irritation) P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P405: Store locked up.
P501: Dispose of contents/container to ... 		It was judged as Category 3 (respiratory irritation) because of a description in NICNAS (2001) referring to confirmation of changes in respiration indicating respiratory irritant through a inhalation exposure test using mice.
9 Specific target organ toxicity - Repeated exposure Not classified - - - - From description that toxicity was not observed with the dose which exceeds the guidance value range for Category 2 in 90 day feeding oral administration test on rats (NICNAS (2001) and ACGIH (7th, 2001)), it was classified as out of Category.
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Not classified - - - - It carried out the outside of Category from 96-hour LC50>100mg/L of fishes (Oryzias latipes) (MOE eco-toxicity tests of chemicals, 1999).
11 Hazardous to the aquatic environment （Long-term） Not classified - - - - Since not water-insoluble (aqueous solubility =55.6g/100mL(ICSC, 1993)) and acute toxicity is low.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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