GHS Classification Result

Chemical Name：Benzo[a]pyrene
CAS：50-32-8

Result：
ID: 951
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Classification not possible - - - - No data available by regulated examination methods, though "Flammable" (ICSC (J) (1997))
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Classification not possible - - - - No data available
11 Self-heating substances and mixtures Classification not possible - - - - No data available
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not applicable - - - - Containing no oxygen , chlorine and fluorine.
15 Organic peroxides Not applicable - - - - Containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - Liquid at a test temperature, 55degC. Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Classification not possible - - - - The only LD50 value acquired is >1600mg/kg (EHC 202, 1998) in a mouse. This data might be considered as category 4, category 5 or out of category. But we concluded that the value could not be classified because we were not sure which choise was adequate.
1 Acute toxicity （Dermal） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Solid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P362: Take off contaminated clothing and wash before reuse. 		There was no concrete case report. But it was set as Category 2 from description that the irritation accompanied by erythema and burning sensations was in the skin in the humans (HSDB (2005), HSFS (1998), and SITTIG (4th, 2002)).
3 Serious eye damage/eye irritation Classification not possible - - - - Insufficient data available.
4 Respiratory sensitization Classification not possible - - - - Although there was description in CERI Hazard Data (1997) that it is told to be related to allergy as effect on humans, since there was no evidence showing to induce respiratory hypersensitivity by inhalation exposure to human, we presupposed that we could not classify for the insufficiency of data.
4 Skin sensitization Classification not possible - - - - Although there is description that contact sensitivity was acknowledged in the test using the guinea pigs and mouse of EHC 202 (1998) and ATSDR (1995), the positive rate was unknown, likewise, although there was description that it is said to be related to allergy as effect on human in CERI Hazard Data (1997), there was no evidence which shows that it induces hypersensitivity by skin contacts, therefore we presupposed that we could not classify it for the insufficiency of data.
5 Germ cell mutagenicity Category 1B Danger H340: May cause genetic defects P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		There is a positive result (EHC 202, 1998; ATSDR, 1995) by the dominant lethal test using a mouse, which is an in vivo multigeneration mutagenicity test using a germ cell. So it is set as Category 1B.
6 Carcinogenicity Category 1B Danger H350: May cause cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		It was classified into B-2 (IRIS, 2005) in EPA in 1994. But it was in group 2A (IARC Suppl.7, 1987) in IARC, 2A (industrial hygene academic society recommentation, 2005) in Japan Assoc. of Industrial Health and ACGIH, 2A (ACGIH 7th, 2001) in ACGIH, R (NTP RoC 11th, 2005) in NTP and the category 2 (EU-Annex I, 2005) in EU. So it was considered as Category 1B according to the classification of NTP which is latest assessment document.
7 Reproductive toxicity Category 1B Danger H360: May damage fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		It was considered as Category 1B based on the description that the impact on reproductive potential was acknowledged at the dose in which general toxicity is not observed in the dam animals by the oral administration examination in pregnancy mouse (EHC 202 (1998), CERI Hazard Data (1997), IARC 32 (1983), ATSDR (1995)), although there is the strain differences.
8 Specific target organ toxicity - Single exposure Classification not possible - - - - No data available.
9 Specific target organ toxicity - Repeated exposure Category 2 (bone marrow, respiratory system) Warning H373: May cause damage to organs through prolonged or repeated exposure (bone marrow, respiratory system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		Based on descriptions that the oral administration studies on mice, myelosuppression was observed with the administration within the guidance value range for Category 2 in spite of strain differences (EHC 202 (1998), CERI Hazard Data (1997), IARC 32 (1983) and ATSDR (1995)), it was classified into Category 2 (medullary). Moreover, although there is description that it is said to be related to respiratory disorders and pulmonary emphysema as a chronic effects on humans (CERI Hazard Data (1997)), there was no concrete case report, and since the classification to Category 1 could not be justified, it was classified as Category 2 (respiratory tracts).
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		It was classified into Category 1 from 24-hour EC50=40microg/L of Crustacea(Daphnia magna) (MOE Risk Assessment No.2, 2003).
11 Hazardous to the aquatic environment （Long-term） Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Classified into Category 1, since acute toxicity is Category 1, supposed not rapidly degrading (BIOWIN), and bioaccumulative (log Kow=6.13 (PHYSPROP Database, 2005)).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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