GHS Classification Result

Chemical Name:Isophthalonitrile
CAS:626-17-5

Result:
ID: 967
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual (10 Feb, 2006)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Classification not possible - - - - No data available
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Classification not possible - - - - No data available
11 Self-heating substances and mixtures Classification not possible - - - - No data available
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not applicable - - - - Containing no oxygen , chlorine and fluorine.
15 Organic peroxides Not applicable - - - - Containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - Liquid at a test temperature, 55degC. Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ...
Rat LD50 value: 711mg/kg (the Health, Labor and Welfare Ministry reports, 2005) and >5000mg/kg (ACGIH 7th, 2001). Based on the values above, the lower value was adopoted, and it was classified to category 4.
1 Acute toxicity (Dermal) Classification not possible - - - - There was the description that rabbit LD50 value: >2000mg/kg (RTECS, 2005). But the existence of death by 2000mg/kg administration was unknown, it cannot be classified.
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Solid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - There was description that effect was not admitted by 1-hour exposure (4-hour equivalent 2.243mg/L) of 8.97mg/L to a rat (ACGIH (7th, 2001)). But there is no other data, and category was not specificked. Therefore, it cannot classify.
2 Skin corrosion/irritation Not classified - - - - From description that skin changes were not admitted in the test applied to the skin of the rabbit on ACGIH (7th, 2001), it was judged that there was no irritation and was carried out the outside of Category.
3 Serious eye damage/eye irritation Not classified - - - - Based on the description that no irritant property was acknowledged in the test applied to the eyes of the rabbits (ACGIH (7th, 2001)), we classified it as Out Of Category.
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Classification not possible - - - - No data available
5 Germ cell mutagenicity Classification not possible - - - - Since there is only negative data, it cannot be classified according to an in vitro examination (Ames test, chromosome aberration test).
6 Carcinogenicity Classification not possible - - - - No data available
7 Reproductive toxicity Classification not possible - - - - No data available
8 Specific target organ toxicity - Single exposure Classification not possible - - - - No data available.
9 Specific target organ toxicity - Repeated exposure Category 2 (liver, kidney) Warning H373: May cause damage to organs through prolonged or repeated exposure (liver, kidney) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
Based on the descriptions that the effects on the liver was observed with the dose within the guidance value range for Category 2 and the renal effects on male rats was observed with the dose within the guidance value range for Category 1 in the 28 day oral study on rats (the Health, Labor and Welfare Ministry reports (2005)), the target organ was thought to be liver and kidney. However, the hyaline droplets of proximal renal tubule as renal effects can be alpha 2u-globulin renal syndrome specific to male rats. As it could not fully be sure to justify the classification as Category 1, it was classified as Category 2 (liver, kidney).
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Classification not possible - - - - Insufficient data available.
11 Hazardous to the aquatic environment (Long-term) Classification not possible - - - - Classification not possible due to lack of data


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model SDS by MHLW

MHLW Website (in Japanese Only)


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