GHS Classification Result

Chemical Name：Tris(o-cresyl) phosphate
CAS：78-30-8

Result：
ID: 1008
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Not classified - - - - Flash point: >93degC
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not classified - - - - Flash point: 385degC (ICSC (J), 1994)
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Not classified - - - - UNRTDG Class: 6.1
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified - - - - UNRTDG Class: 6.1
13 Oxidizing liquids Not classified - - - - UNRTDG Class: 6.1
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Containing no -0-0- structure
16 Corrosive to metals Not classified - - - - UNRTDG Class: 6.1

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Not classified - - - - SPECIES: Rat ENDPOINT: LD50 VALUE: 3000-10000 mg/kg REFERENCE SOURCE: ACGIH (7th, 2001), PATTY (4th, 1994)
1 Acute toxicity （Dermal） Not classified - - - - It was set as the outside of Category based on rabbit LD50 value: >3700mg/kg (RTECS, 2006) and the description that a minimum lethal dose is within the range of 3160 - 5160mg/kg (HSDB, 2006).
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available
2 Skin corrosion/irritation Not classified - - - - From description that it is not the skin irritation on PATTY (4th, 1994), it was carried out the outside of Category.
3 Serious eye damage/eye irritation Classification not possible - - - - No data available
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Classification not possible - - - - No data available
5 Germ cell mutagenicity Classification not possible - - - - Although there is a positive result (RTECS, 2006) by the adduct bond test with somatic DNA of the rat (liver, kidney, lung, and heart) which is an in vivo genotoxicity study using a somatic, there is no positive result by in vitro mutagenicity test. So it cannot classify.
6 Carcinogenicity Not classified - - - - Since it was classified into A4 (ACGIH 7th, 2001) in ACGIH, it was considered as the outside of Category.
7 Reproductive toxicity Classification not possible - - - - Classification not possible due to lack of data
8 Specific target organ toxicity - Single exposure Category 1 (nervous system) Danger H370: Causes damage to organs (nervous system) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		The substance was classified as Category 1 (nervous system) based on the reports of effects on the nervous system in oral ingestion cases in humans (ACGIH (7th, 2001) and PATTY (4th, 1994)).
9 Specific target organ toxicity - Repeated exposure Category 1 (nervous system) Danger H372: Cause damage to organs through prolonged or repeated exposure (nervous system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		We classified it into Category 1 (nerve systems) based on the description that the effects on the nerve systems was observed in occupational exposure examples (ACGIH (7th, 2001) and PATTY (4th, 1994)). Moreover, in the oral study using a rat, the effects on the nervous system was observed with the given dose of the guidance value range of Category 2 (RTECS, 2006).
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Classification not possible - - - - Insufficient data available.
11 Hazardous to the aquatic environment （Long-term） Classification not possible - - - - Classification not possible due to lack of data


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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