GHS Classification Result

Chemical Name:Triphenyl Phosphate
CAS:115-86-6

Result:
ID: 1010
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual (10 Feb, 2006)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Classification not possible - - - - No data available
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Classification not possible - - - - No data available
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid or solid substances at 140degC are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Classification not possible - - - - No data available
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Classification not possible - - - - No data available
15 Organic peroxides Not applicable - - - - Containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - No data available

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 5 - Warning H303: May be harmful if swallowed P312: Call a POISON CENTER or doctor/physician if you feel unwell. Rat LD50 value: 3500mg/kg (MOE Risk Assessment vol.4, 2005, EHC 111, 1991), 3800mg/kg (EHC 111, 1999, ACGIH 7th, 2001, DFGOT vol.2, 1991), 10800mg/kg (EHC 111, 1991, DFGOT vol.2, 1991), >5000mg/kg (EHC 111, 1991) and >6400mg/kg (PATTY 4th, 1994). Calculated based on the data above. Since the calculated values was 3723.1mg/kg, it was classified to category 5.
1 Acute toxicity (Dermal) Not classified - - - - Based on rabbit LD50 value: >7900mg/kg (MOE Risk Assessment the 4th volume, 2005, EHC 111, 1991, DFGOT vol.2, 1991), and >10000mg/kg (DFGOT vol.2, 1991), it was set as the outside of Category.
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Solid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - No data available
2 Skin corrosion/irritation Not classified - - - - From description that irritation was not admitted in the test applied to the skin of the rat for 4 hours on DFGOT (2 vol. 1991) and ACGIH (7th, 2001), it was carried out the outside of Category.
3 Serious eye damage/eye irritation Category 2B - Warning H320: Causes eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
We classified it as Category 2B based on the description that a slight conjunctival reddening was acknowledged and it disappeared within 7 days in the test applied to the eyes of the rabbits (DFGOT(vol.2,1991)).
4 Respiratory sensitization Classification not possible - - - - No data
4 Skin sensitization Classification not possible - - - - ACGIH (7th, 2001) and HSDB (2006) had description of the case report of allergic contact dermatitis, however, both of which were considered to be the same description of one case and did not have the report of two or more cases which is a judging standard of skin sensitization, and we thought the data was insufficient, therefore we presupposed that we could not classify it.
5 Germ cell mutagenicity Classification not possible - - - - Classification not possible due to lack of data
6 Carcinogenicity Not classified - - - - Since it was classified into A4 in ACGIH (ACGIH 7th, 2001), it was considered as the outside of Category.
7 Reproductive toxicity Not classified - - - - It was considered as out of Category based on the description that clear reproductive toxicity was not observed at the dose as which general toxicity is observed in parent animals in the test administered orally before mating till the term pregnancy using rat (MOE Risk Assessment 4th volume (2005), ACGIH (7th, 2001), and EHC 111 (1991)).
8 Specific target organ toxicity - Single exposure Classification not possible - - - - Insufficient data available.
9 Specific target organ toxicity - Repeated exposure Not classified - - - - We classified it into Out Of Category based on the description that in the oral study using the rat, the serious toxic effect was not observed with the dose which exceeds the guidance value range of Category 2 (MOE Risk Assessment The 4th volume (2005), EHC 111 (1991), DFGOT (vol.2, 1991) and ACGIH (7th, 2001)).
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
It was classified into Category 1 from 96-hour LC50=0.18-0.32mg/L of Crustacea (Mysid shrimp) (EHC111, 1991).
11 Hazardous to the aquatic environment (Long-term) Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
Classified into Category 1, since acute toxicity is Category 1, and supposedly bioaccumulative (log Kow=4.59(PHYSPROP Database, 2005)), though rapidly degrading (BOD: 90% (existing chemical substances safety inspections data)).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

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