GHS Classification Result

Chemical Name：1,3-Benzenediol
CAS：108-46-3

Result：
ID: 1011
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Not classified - - - - UNRTDG Class: 6.1
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - Flash point: 585degC (Hommel, 1991, Card No.890)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid or solid substances at 140degC are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not applicable - - - - Organic compounds containing oxygen (but not chlorine and fluorine) and the oxygen is chemically bonded only to carbon and hydrogen (but not to other elements).
15 Organic peroxides Not applicable - - - - Containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - Liquid at a test temperature, 55degC. Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		Rat LD50 value: 980mg/kg (NTP TR 403, 1992, ACGIH 7th., 2001, PATTY 4th., 1994, DFGOT 20, 2003), 202mg/kg, 301mg/kg, 370mg/kg, 489mg/kg, 334mg/kg, 349mg/kg and 502mg/kg (all the data from DFGOT 20, 2003). Based on the toxicity value of 302mg/kg calculated from the data above, it was classified as category 4.
1 Acute toxicity （Dermal） Category 5 - Warning H313: May be harmful in contact with skin P312: Call a POISON CENTER or doctor/physician if you feel unwell. It was set as Category 5 based on rabbit LD50 value: 3360mg/kg (NTP TR 403, 1992, and ACGIH 7th, 2001, DFGOT 20, 2003, PATTY 4th., 1994), and 3830mg/kg (DFGOT 20, 2003).
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Solid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Dusts and mists） Category 5 - Warning H333: May be harmful if inhaled P304+P312: IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell. Based on rat LC50 value by 1 hour exposure: 21.3mg/L (4 hour equivalent: 5.33mg/L (IUCLID 2000)), it was set as Category 5.
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P362: Take off contaminated clothing and wash before reuse. 		From statement that less to moderate irritating was acknowledged in the normal skin in 6-time-as much exposure time as a GHS definitions by the skin irritation test using a rabbit (ACGIH 7th., 2001, DFGOT 20, 2003, PATTY 4th., 1994), it was judged that the strength of skin irritation in a rabbit was moderate or weaker than that, and from statement that skin irritation was acknowledged by occupational exposure in humans (NTP TR 403, 1992, and PATTY 4th., 1994, ACGIH 7th., 2001, International Agency for Res. on Cancer 15, and 1977), it was judged that there was skin irritation in this product, and it was set as Category 2.
3 Serious eye damage/eye irritation Category 1 Danger H318: Causes serious eye damage P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician. 		We classified it as Category 1 based on the descriptions that it caused the irreversible ulcer on the cornea in the eye irritation tests using the rabbits (ACGIH 7th., 2001, DFGOT 20, 2003).
4 Respiratory sensitization Classification not possible - - - - No data
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ... 		Based on the description that there were many case reports that sensitizing was acknowledged in human, and based on description that it was positive (the rate of a positive: 70%) in the test (the Maximization method) using the guinea pig (DFGOT 20, 2003, both human and animal), we classified it to be Category 1.
5 Germ cell mutagenicity Not classified - - - - From description that all are negative by the small core examination which uses the mouse and rat marrow cell which is the in vivo mutagenicity test using a somatic, and the sister chromatid exchange test using a rat marrow cell (NTP TR 403, 1992, ACGIH 7th., 2001, DFGOT 20, 2003, IARC 71, 1999), it carried out the outside of Category. In addition, in the DNA synthesis inhibitory effect test using the mouse spermary cell which is a productive cell in vivo heredity toxicity examination, it is negative (NTP TR 403, 1992, ACGIH 7th., 2001). Moreover, there is description that it is positive in the chromosomal aberration test and gene mutation assay using a mammalian cultured cell among the in vitro mutagenicity test (NTP TR 403, 1992, ACGIH 7th., 2001, DFGOT 20, 2003, IARC 71, 1999, NTP DB 2006), and it is negative in the mutation examination using bacteria (NTP TR 403, 1992, ACGIH 7th., 2001, DFGOT 20, 2003, IARC 15, 1977).
6 Carcinogenicity Not classified - - - - It was considered as the outside of Category based on being classified into Group 3 (IARC 71, 1999) in IARC, A4 (ACGIH 7th.2001) in ACGIH,
7 Reproductive toxicity Classification not possible - - - - It cannot be classified due to the unknown effects on the generative function etc., although in the study it was administered orally to the fetal organ formative period in the pregnant rat and mouse, and fetus toxicity and teratogenicity were not observed even in the dose which indicates inbitation of weight gains to dam (NTP TR 403, 1992; ACGIH 7th., 2001; DFGOT 20, 2003; IARC 71, 1999).
8 Specific target organ toxicity - Single exposure Category 1 (blood, central nervous system, respiratory system, cardiovascular system) Danger H370: Causes damage to organs (blood, central nervous system, respiratory system, cardiovascular system) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		It was judged that the target organs of this substance were blood, central nervous system, respiratory system and cardio-vascular system because it is reported that oral inoculation or percutaneous exposure may cause death in humans after showing restlessness, methemoglobinemia, cyanosis, dizziness, drowsiness, convulsions, tachycardia, dyspnea, decrease of body temperature, decrease of blood pressure and respiratory rate, and jaundice (PATTY 4th., 1994). So it was classified as Category 1 (blood, central nervous system, respiratory system, cardio-vascular system).
9 Specific target organ toxicity - Repeated exposure Category 1 (thyroid) Danger H372: Cause damage to organs through prolonged or repeated exposure (thyroid) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		In the test of drinking water administration to the rat for 12 weeks, with the dosage of guidance value range of Category 1, the average height of the follicular cell of the thyroid gland increased significantly, and the mean diameter of the follicle was significantly small. Since the author considered it as the precursor stage for the onset of goiter, the effect to thyroid function was not clear, however, we judged that the thyroid might be affected and we classified it into Category 1 (thyroid).
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 3 - - H402: Harmful to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		It was classified into Category 3 from 96-hour LC50=32.7mg/L of Crustacea (glass shrimp) (ECETOC TR91, 2003).
11 Hazardous to the aquatic environment （Long-term） Not classified - - - - Since rapidly degrading (BOD: 66.7% (existing chemical safety inspections data)), and less bio-accumulative (log Kow=0.8 (PHYSPROP Database, 2005)).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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