GHS Classification Result

Chemical Name：ethoprophos
CAS：13194-48-4

Result：
ID: 1025
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Not classified - - - - Not classified because of its flash point: 140degC(closed cup) (PM 13th, 2003)
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not classified - - - - Uses are agricultural chemicals, and even if it contacts the normal temperature air, it does not ignite spontaneously.
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified - - - - Stable to wate (PM, 13th, 2003)
13 Oxidizing liquids Classification not possible - - - - No data available
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Organic compounds containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - Classification not possible due to lack of data. Non-corrosive to metals (HSDB, 2004)

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 2 Danger H300: Fatal if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ... 		After calculation based on the rat oral LD50 value (52, 33 and 56mg/kg) (JMPR 629 (1983), JMPR961 (1999)), it was classified as category 2.
1 Acute toxicity （Dermal） Category 1 Danger H310: Fatal in contact with skin P302+P350: IF ON SKIN: Gently wash with plenty of soap and water.
P262: Do not get in eyes, on skin, or on clothing.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P322: Specific treatment （see ... on this label）.
P361: Remove/Take off immediately all contaminated clothing.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Rat dermal LD50 = 226mg/kg. (Since LD50 value based on three data (226, 1280 amd 424mg/kg) (JMPR 961 (1999)) was lower than the lowest value of the used data, the lowest value of used data was adopted.) Moreover, rabbit dermal LD50 = 8.5mg/kg. (Since LD50 value = 26mg/kg (PDS 70 (1988)) and 8.5mg/kg (JMPR 961 (1999)), and high toxicity value is adopted.) Both were compared and it was set as Category 1 from the value with a lower numerical value (8.5mg/kg).
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Dusts and mists） Category 2 Danger H330: Fatal if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P284: Wear respiratory protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P320: Specific treatment is urgent （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Category 2 because of "SPECIES: Rat; ENDPOINT: LC50(4hr.); VALUE:0.250 mg/L"(JMPR 961, 1999)
2 Skin corrosion/irritation Category 3 - Warning H316: Causes mild skin irritation P332+P313: If skin irritation occurs: Get medical advice/attention. Since the slight stimulus (slight irritation) was seen with the rabbit, it was set as Category 3.
3 Serious eye damage/eye irritation Category 2A-2B Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection. 		Since actinic erythema (moderate) and the scleral and angiogenesis of nictitating membrane were observed in eyes of rabbits, it was classified into Category 2A-2B. [Indication] 2A is recommended based on the safety, when the Category needs to subdivide.
4 Respiratory sensitization Classification not possible - - - - No data
4 Skin sensitization Classification not possible - - - - It was classified as R43 according to the Risk epigrams of EU and it was suggested that it had skin sensitization property, however, there was no data which upholds this information concretely, therefore we presupposed that we could not classify it.
5 Germ cell mutagenicity Not classified - - - - The result of the in vivo mutagenicity (the chromosomal aberration test using rat marrow cell, the dominant fatality examination using a rat) is negative (one in the dominant fatality examination using a rat is equivocal) (JMPR 629(1983), JMPR 961(1999)), it carried out the outside of Category by the classification guidelines.
6 Carcinogenicity Classification not possible - - - - There is data in which male rats show the increase in thyroid C-cell adenoid tumor and adrenal gland malignant brown androblastoma (JMPR 629 (1983), PDS 70 (1988), HSDB (2004)), and increase of endometrial polyps is shown by a female rats (HSDB (2004)). But there was no data which leads to human's carcinogenicity directly and evaluation by evaluation organization was not conducted. So it was presupposed that it cannot be classified.
7 Reproductive toxicity Not classified - - - - Even the result of the animal experiments using rat or rabbit is uninfluential, or impact is seen, the extent is small (ossification insufficiency etc.), moreover, since impact was not seen in the two-generation test of rat and the rabbit carried out by GLP based on the OECD guideline. So it was considered as the outside of Category (PDS 70 (1988), JMPR 629 (1983), JMPR 961 (1999)).
8 Specific target organ toxicity - Single exposure Category 1 (nervous system) Danger H370: Causes damage to organs (nervous system) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		The substance was classified as Category 1 (nervous system). Because there is a report in a Priority document that effects on the nerves originating from cholinesterase inhibition (tremors, protrusion of the eyeballs, impaired coordination and excessive salivation) were observed in rats after exposure to an amount equivalent to the guidance value of Category 1 (JMPR 961(1999)).
9 Specific target organ toxicity - Repeated exposure Category 1 (liver), Category 2 (nervous system) Danger
Warning 		H372: Cause damage to organs through prolonged or repeated exposure (liver)
H373: May cause damage to organs through prolonged or repeated exposure (nervous system) 		P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		In the document of Priority 1,we found the finding which suggests hepatotoxicity to a dog with the dose which is equivalent to Category 1 in the guidance value range (JMPR 765 (1987)), therefore we classified it into Category 1 (liver). Furthermore, in the document of Priority 1, the subtle changes (vomiting, a loose stool, etc.) which are considered to be based on cholinesterase inhibition were observed to a rat with the dose which is equivalent to Category 2 in the guidance value range (JMPR 629 (1983)), therefore we classified it into Category 2 (nervous systems).
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		It was classified into Category 1 from 96-hour LC50=0.02ppm of Crustacea (Mysid shrimp) (HSDB, 2004).
11 Hazardous to the aquatic environment （Long-term） Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Classified into Category 1, since acute toxicity was Category 1, supposed not rapidly degrading (BIOWIN), though supposed less bioaccumulative (log Kow=3.59(PHYSPROP Database, 2005)).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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