GHS Classification Result

Chemical Name：calcium arsenate
CAS：7778-44-1

Result：
ID: 1074
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Not classified - - - - Non-combustible (ICSC (J) (1999))
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - Non-combustible (ICSC (J), 1999)
11 Self-heating substances and mixtures Not classified - - - - Not combustible (ICSC(J) (1999))
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified - - - - Stable to water (the water solubility is obtained)
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not classified - - - - UNRTDG No. 1573, Class: 6.1; PG II (Not 5.1).
15 Organic peroxides Not applicable - - - - Inorganic compound
16 Corrosive to metals Classification not possible - - - - Although HSDB (2002) has the description "corrosion behavior is slightly", test methods suitable for a solids material are not established.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 2 Danger H300: Fatal if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ... 		From rat LD50 value of 20mg/kg and 298mg/kg (HSDB, 2002) of the oral study, the lower value of 20mg/kg was adopted to classify as category 2.
1 Acute toxicity （Dermal） Category 5 - Warning H313: May be harmful in contact with skin P312: Call a POISON CENTER or doctor/physician if you feel unwell. It was set as Category 5 based on rat LD50 = 2400mg/kg (HSDB, 2002) of the dermal administration test.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Solid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available
2 Skin corrosion/irritation Category 3 - Warning H316: Causes mild skin irritation P332+P313: If skin irritation occurs: Get medical advice/attention. This product was set to Category 3 from description with redness which stimulated the skin (ICSC(J), 1999; SITTIG, 4th, 2002).
3 Serious eye damage/eye irritation Category 2B - Warning H320: Causes eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling. 		Since there are the descriptions that this product irritates to the eye, causes redness and pain (ICSC(J)1999; HSDB, 2003; SITTIG, 4th, 2002), it was classified into Category 2B.
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Classification not possible - - - - It is not a deterministic conclusion, although there is no knowledge of this product and skin sensitization may be indicated to humans as an inorganic arsenic (ATSDR, draft, 2005; HSG, 70, 1992), in addition, it was presupposed that it cannot classify from the description in the humans of EHC 224 (2001) "development of the skin sensitization of inorganic arsenic is rare" since data is insufficient.
5 Germ cell mutagenicity Classification not possible - - - - Without data. In addition, arsenic and inorganic arsenic compound are classified into the germ-cell mutagenicity category 3A (equivalent for GHS Category 1B-2) according to MAK/BAT (2005).
6 Carcinogenicity Category 1A Danger H350: May cause cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Since arsenic and arsenic compound are categorized into the human carcinogens in IARC Suppl.7 (1987), ACGIH-TLV (2005), and MAK/BAT (2005), it was classified into Category 1A.
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Although the specific data of this product was not observed within the range of investigation, since there is the description that this product is suggested the teratogenicity in humans based animal studies (ICSC (1999)), in addition, in ACGIH (7th, 2001), ATSDR (draft, 2005), EHC 224 (2001), and DFGOT vol.21 (2005), although there was an opposite report, the reproductive and developmental toxicity knowledge by inorganic arsenic was indicated to laboratory animals. So it was considered as Category 2.
8 Specific target organ toxicity - Single exposure Category 1 (digestive system, cardiovascular system, nervous system, kidney, liver, respiratory system) Danger H370: Causes damage to organs (digestive system, cardiovascular system, nervous system, kidney, liver, respiratory system) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		The substance was classified as Category 1 (gastrointestinal system, cardio-vascular system, nervous system, kidneys, liver, respiratory system) based on the following reports that in the forms of the arsenic and inorganic arsenic compounds it causes "symptoms in the gastrointestinal organs, disorders in the functions of the cardio-vascular and nervous systems, myelosuppression, alteration in the blood system and nephropathy" in humans (EHC 224 (2001)), and that it affects the liver, upper airways and lungs (ACGIH (7th, 2001)), and that it affects digestive tracts, circulatory system, central nervous system and kidney, and may cause serious gastroenteritis, body fluid and electrolyte losses, cardiac and renal problems and shock (ICSC (J) 1999).
9 Specific target organ toxicity - Repeated exposure Category 1 (digestive system, cardiovascular system, nervous system, kidney, liver, blood system, skin, respiratory system) Danger H372: Cause damage to organs through prolonged or repeated exposure (digestive system, cardiovascular system, nervous system, kidney, liver, blood system, skin, respiratory system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		The description in the humans of EHC 224 (2001) about arsenic and inorganic arsenics compounds, "disorders of gastrointestinal , neuropathy, effect to blood systems, abnormalities of cardiovascular systems, kidney, and liver were observed in the long term oral administration of inorganic arsenic. Target organ are gastrointestinal,heart,brains and kidney. The skin, marrow, and peripheral nerves are affected." It was classified into Category 1 (a digestive tract, a cardiovascular systems, a nervous systems, the kidney, liver, blood systems, skin, respiratory system) based on above discription and, in addition, the description of the effect on upper respiratory tracts and lungs (ACGIH (7th, 2001)), and the description that it affects the skin, mucosa, the peripheral nervous systems, marrow, and liver, pigmentation disorder, nasal septal perforation, neuropathy, damage to blood cells, and liver damage may occure (ICSC (J), 1999).
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Classification not possible - - - - Insufficient data available.
11 Hazardous to the aquatic environment （Long-term） Classification not possible - - - - Classification not possible due to lack of data


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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