GHS Classification Result

Chemical Name：disodium hydrogenarsenate
CAS：7778-43-0

Result：
ID: 1079
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Not classified - - - - Non-combustible (ICSC (J) (1999))
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - Non-combustible (ICSC (J), 1999)
11 Self-heating substances and mixtures Not classified - - - - Not combustible (ICSC(J) (1999))
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified - - - - Stable to water (the water solubility is obtained)
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not classified - - - - UNRTDG No. 1685, Class: 6.1; PG II (Not 5.1).
15 Organic peroxides Not applicable - - - - Inorganic compound
16 Corrosive to metals Classification not possible - - - - Test methods suitable for a solids material are not established. In addition, ICSC (J) (1999) have the description "it corrodes much metal, such as iron, aluminum and zinc under presence of water, and toxic fumes (arsenic, arsine) is generated."

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Classification not possible - - - - No data available
1 Acute toxicity （Dermal） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Solid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P362: Take off contaminated clothing and wash before reuse. 		This product was set to Category 2 from description with redness, the pain which stimulated the skin (ICSC(J), 1999; SITTIG, 4th, 2002).
3 Serious eye damage/eye irritation Category 2B - Warning H320: Causes eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling. 		Since there are the descriptions that this product irritates to the eye, causes redness and pain (ICSC(J)1999; HSDB, 2003; SITTIG, 4th, 2002), it was classified into Category 2B.
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Classification not possible - - - - Although there is no data of this substance itself, skin sensitization may be indicated to humans as an inorganic arsenic, but it is not a deterministic conclusion (ATSDR, 2005;HSG, 1992), in addition, it was presupposed that it cannot classify from the description in the humans of EHC 224 (2001) "development of the skin sensitization of inorganic arsenic is rare" since data is insufficient.
5 Germ cell mutagenicity Classification not possible - - - - Without data. In addition, arsenic and inorganic arsenic compound are classified into the germ-cell mutagenicity category 3A (equivalent for GHS Category 1B-2) according to DFG (MAK/BAT, 2005).
6 Carcinogenicity Category 1A Danger H350: May cause cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Since arsenic and arsenic compound are categorized into the human carcinogens in IARC Suppl.7 (1987), ACGIH-TLV (2004), and MAK/BAT (2004), it was classified into Category 1A.
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		In "a possibility that the human baby will cause malformation in an animal experiments" in ICSC (J) (1999) of Priority 2 document, and in ACGIH (7th, 2001), ATSDR (draft, 2005), EHC 224 (2001), and DFGOT Vol.21 (2005), although there was an opposite report, the reproductive and developmental toxicity knowledge by inorganic arsenic was indicated to laboratory animals. So it was considered as Category 2.
8 Specific target organ toxicity - Single exposure Category 1 (digestive system, cardiovascular system, nervous system, kidney, liver, respiratory system) Danger H370: Causes damage to organs (digestive system, cardiovascular system, nervous system, kidney, liver, respiratory system) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		The substance was classified as Category 1 (gastrointestinal system, cardio-vascular system, nervous system, kidneys, liver, respiratory system). Based on the following reports that it affects gastrointestinal tracts, cardio-vascular system, central nervous system and kidneys, and may cause serious gastroenteritis, and body fluid and electrolyte losses, cardiac and renal damages, collapse and shock (ICSC (J) 1999), and that in the forms of the arsenic and inorganic arsenic compounds it causes "symptoms in the gastrointestinal organs, disorders in the functions of the cardio-vascular and nervous systems, myelosuppression, alteration in the blood system and nephropathy" in humans (EHC 224 (2001)), and that it affects the liver, upper airways and lungs (ACGIH (7th, 2001)).
9 Specific target organ toxicity - Repeated exposure Category 1 (digestive system, cardiovascular system, nervous system, kidney, liver, blood system, skin, respiratory system) Danger H372: Cause damage to organs through prolonged or repeated exposure (digestive system, cardiovascular system, nervous system, kidney, liver, blood system, skin, respiratory system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		Since this product affects the peripheral nervous system, the skin, mucosa, marrow, the kidney, and liver, neuropathy, pigmentation disorder, nasal septal perforation, disorder of blood cells and kidney, and cirrhosis may be occured (ICSC (J) 1999), and the description in human of EHC 224 (2001) about arsenic and inorganic arsenics compounds, "the abnormalities of gastrointestinal disturbances, neuropathy, and the effect on blood systems, a cardiovascular systems, the kidney, and liver were observed. Target organ are gastrointestinal,heart,brains and kidney. Skin,marrow and peripheral nerves were also affected " and in addition, based on the description of effect on the upper respiratory tract and lungs (ACGIH (7th, 2001)) it was classified into Category 1 (digestive tract, cardiovascular systems, nervous systems, kidney, liver, blood systems, skin, respiratory system).
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 2 - - H401: Toxic to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		It was classified into Category 2 from 96-hour LC50=1.74mg/L of Crustacea (Mysid shrimp) (ECETOC TR91, 2003).
11 Hazardous to the aquatic environment （Long-term） Category 2 - H411: Toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Classified into Category 2, since acute toxicity was Category 2 and it is a metallic compound, behavior in water and bioaccumulative potential are unknown.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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