GHS Classification Result

Chemical Name：tricalcium diarsenite
CAS：27152-57-4

Result：
ID: 1087
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Not classified - - - - It is classified into 6.1 and II according to the U.N. number (1574) as a mixture with calcium arsenate. Since 4.1 was not assigned, it was considered as out of Category.
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - It is classified into 6.1, II according to the U.N. number (1574) as a mixture with calcium arsenate. Since 4.2 was not attached, it was defined as "out of Category".
11 Self-heating substances and mixtures Not classified - - - - It is classified into 6.1 and II according to the U.N. number (1574) as a mixture with calcium arsenate. Since 4.2 was not attached, it carried out the outside of Category.
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified - - - - It is classified into 6.1 and II according to the U.N. number (1574) as a mixture with calcium arsenate. Since 4.3 was not attached, it carried out the outside of Category.
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not classified - - - - Not classified because of UNRTDG No. 1574 (compounds with calcium arsenate), Class: 6.1, PG II (not Class: 5.1).
15 Organic peroxides Not applicable - - - - Inorganic compound
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 1 Danger H300: Fatal if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ... 		SPECIES: Mouse; ENDPOINT: LD50; VALUE: 1mg/kg; REFERENCE SOURCE: RTECS (2004)
1 Acute toxicity （Dermal） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Solid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available
2 Skin corrosion/irritation Category 3 - Warning H316: Causes mild skin irritation P332+P313: If skin irritation occurs: Get medical advice/attention. From description that irritation is indicated as an inorganic arsenic compound (PIM 042, 1996;DFGOT vol.21, 2005), it was judged that it had slight irritation and it was set as Category 3.
3 Serious eye damage/eye irritation Category 2B - Warning H320: Causes eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling. 		Since there is the description that inorganic arsenic compounds particulate irritates to the eye (HSG 70, 1992; PIM 042, 1996), it was classified into Category 2B.
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Classification not possible - - - - It is not firm conclusions although skin sensitization may be shown to humans as an inorganic arsenic compound (ATSDR, 2005; PIM 42, 1996), in addition, the description in the humans "development of the skin sensitization of inorganic arsenic is rare"of EHC 224 (2001), and there is a negative report in a guinea pig examination (maximization test) as an inorganic arsenic compound (ATSDR, 2005; EHC 224, 2001), it was presupposed that it cannot classify according to the shortage of data.
5 Germ cell mutagenicity Category 2 Warning H341: Suspected of causing genetic defects P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Although there is no this product data, chromosome aberration or micronucleus is induced to humans (peripheral blood) or rodents (marrow) as an inorganic arsenic compound (DFGOT vol.21, 2005; EHC 224, 2001; PATTY 5th, 2001; IARC Suppl.7, 1987; IARC 84, 2004; ATSDR draft, 2005). So it is set as Category 2. In addition, the inorganic arsenic (As+3) was negative in the dominant fatality examination and the mouse energy proto-cell chromosomal aberration test (ATSDR draft, 2005).
6 Carcinogenicity Category 1A Danger H350: May cause cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		No finding of this product is observed. But inorganic arsenic compound is categorized into human carcinogen in IARC(IARC Suppl.7, 1987; IARC 84, 2004), ACGIH(ACGIH, 7th, 2001), DFG(MAK/BAT, 2005), NTP(NTP RoC 11th, 2005). Therefore, it was clasiffied into Category 1A.
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		There is no data of this product, but in ACGIH (7th, 2001), ATSDR (draft, 2005), EHC 224 (2001), and DFGOT vol.21 (2005) there was an opposite report. Since the reproductive and developmental toxicity knowledge by inorganic arsenic was indicated in laboratory animals, it was considered as category 2.
8 Specific target organ toxicity - Single exposure Category 2 (digestive system, cardiovascular system, kidney, nervous system), Category 3 (respiratory tract irritation) Warning H371: May cause damage to organs (digestive system, cardiovascular system, kidney, nervous system)
H335: May cause respiratory irritation (respiratory tract irritation) 		P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P405: Store locked up.
P501: Dispose of contents/container to ...
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell. 		Although there are no data for this substance itself, it was classified as Category 2 (gastrointestinal system, cardio-vascular system, kidneys, nervous system) and Category 3 (airway irritant). Based on the report of the effects of the substance in the form of an inorganic arsenic compound on the gastrointestinal system, cardio-vascular system, kidneys, liver and nervous system (EHC 224, 2001; HSG 70, 1992), and of its airway irritant properties (HSG 70, 1992; PIM 042, 1996).
9 Specific target organ toxicity - Repeated exposure Category 2 (skin, digestive system, nervous system, lung, liver, cardiovascular system) Warning H373: May cause damage to organs through prolonged or repeated exposure (skin, digestive system, nervous system, lung, liver, cardiovascular system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		Although there is no data of this product itself, since it effects on the skin, a gastrointestinal, nervous systems, lungs, liver, and a cardiovascular system by as inorganic arsenic compounds (EHC 224, 2001;HSG 70, 1992), it was classified into Category 2 (the skin, a gastrointestinal, a nervous systems, lungs, liver, cardiovascular system).
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Classification not possible - - - - No data available
11 Hazardous to the aquatic environment （Long-term） Classification not possible - - - - No data available.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

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Model SDS by MHLW

 MHLW Website （in Japanese Only）

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