Chemical Name:lead arsenite
CAS:10031-13-7
ID: | 1089 |
Classifier: | Inter-ministerial Committee on GHS |
Year Classified: | FY2006 |
Reference Manual: | GHS Classification Manual (10 Feb, 2006) |
Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
---|---|---|---|---|---|---|---|
1 | Explosives | Not applicable | - | - | - | - | There are no chemical groups associated with explosive properties present in the molecules. |
2 | Flammable gases (including chemically unstable gases) | Not applicable | - | - | - | - | Solid (GHS definition) |
3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products |
4 | Oxidizing gases | Not applicable | - | - | - | - | Solid (GHS definition) |
5 | Gases under pressure | Not applicable | - | - | - | - | Solid (GHS definition) |
6 | Flammable liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
7 | Flammable solids | Not classified | - | - | - | - | Non-combustible (ICSC (J) (1999)) |
8 | Self-reactive substances and mixtures | Not applicable | - | - | - | - | There are no chemical groups associated with explosive or self-reactive properties present in the molecule. |
9 | Pyrophoric liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
10 | Pyrophoric solids | Not classified | - | - | - | - | Non-combustible (ICSC (J), 1999) |
11 | Self-heating substances and mixtures | Not classified | - | - | - | - | Not combustible (ICSC(J) (1999)) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified | - | - | - | - | Stable to water (insoluble in water) |
13 | Oxidizing liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
14 | Oxidizing solids | Not classified | - | - | - | - | UNRTDG No. 1618, Class: 6.1; PG II (Not 5.1). |
15 | Organic peroxides | Not applicable | - | - | - | - | Inorganic compound |
16 | Corrosive to metals | Classification not possible | - | - | - | - | Test methods applicable to solid substances are not available. |
Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Classification not possible | - | - | - | - | No data available |
1 | Acute toxicity (Dermal) | Classification not possible | - | - | - | - | No data available |
1 | Acute toxicity (Inhalation: Gases) | Not applicable | - | - | - | - | Solid (GHS definition) |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible | - | - | - | - | No data available |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible | - | - | - | - | No data available |
2 | Skin corrosion/irritation | Category 3 | - | Warning | H316: Causes mild skin irritation | P332+P313: If skin irritation occurs: Get medical advice/attention. | From the description that irritation is indicated in the human skin (ICSC, 1999;HSFS, 2001), and the description that irritation is indicated as an inorganic arsenic (PIM 042, 1996;DFGOT vol.21, 2005) , it was judged that it had slight irritation and was set as category 3. |
3 | Serious eye damage/eye irritation | Category 2B | - | Warning | H320: Causes eye irritation |
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313: If eye irritation persists: Get medical advice/attention. P264: Wash ... thoroughly after handling. |
Due to the descriptions that it irritates to human eyes (ICSC, 1999; HSFS, 2001), and that inorganic arsenic dust shows eye irritation (HSG 70, 1992-IM 042, 1996), it was classified into Category 2B. |
4 | Respiratory sensitization | Classification not possible | - | - | - | - | No data available |
4 | Skin sensitization | Classification not possible | - | - | - | - | By the this substance (ICSC, 1999), or it is not firm conclusions although skin sensitization may be shown to humans as an inorganic arsenic compound (ATSDR, 2005; PIM 42, 1996), in addition, the description in the humans "development of the skin sensitization of inorganic arsenic is rare"of EHC 224 (2001), and there is a negative report in a guinea pig examination (maximization test) as an inorganic arsenic compound (ATSDR, 2005; EHC 224, 2001), it was presupposed that it cannot classify according to the shortage of data. |
5 | Germ cell mutagenicity | Category 2 | Warning | H341: Suspected of causing genetic defects |
P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ... |
There is no this product data, chromosome aberration or micronucleus is induced to humans (peripheral blood) or rodents (marrow) as an inorganic arsenic compound (DFGOT vol.21, 2005; EHC 224, 2001; PATTY 5th, 2001; IARC Suppl.7, 1987; IARC 84, 2004; ATSDR draft, 2005). And a lead (inorganic lead compound) induces a human heterochromosome in ATSDR, and the inorganic arsenic compound and the inorganic lead compound are classified into 3A in MAK/BAT(2005). So it is set as 2. In addition, the inorganic arsenic (As+3) was negative in the dominant fatality examination and the mouse energy proto-cell chromosomal aberration test (ATSDR draft, 2005). | |
6 | Carcinogenicity | Category 1A | Danger | H350: May cause cancer |
P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ... |
No finding of this product is observed. But inorganic arsenic compound is categorized into human carcinogen in IARC(IARC Suppl.7, 1987; IARC 84, 2004), ACGIH(ACGIH, 7th, 2001), DFG(MAK/BAT, 2005), NTP(NTP RoC 11th, 2005). Therefore, it was clasiffied into Category 1A. In addition, as lead compound (inorganic), it corresponds to Category 1B (Group 2A) in IARC 87 (2004), it corresponds to Category 1B-2 in NTP RoC (11th, 2005) (Reasonably anticipated to be human carcinogens), and it corresponds to Category 2 (B-2, A3, respectively) in IRIS (1993) and ACGIH-TLV (2005),. | |
7 | Reproductive toxicity | Category 1B | Danger | H360: May damage fertility or the unborn child |
P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ... |
Although the specific knowledge about this product was not observed, this product will induce the reproductive toxicity seriously for humans (ICSC, 1999). And although there is a report which conflicts in ACGIH (7th, 2001), ATSDR (draft, 2005), EHC 224 (2001) and DFGOT vol.21 (2005) as an inorganic arsenic, the knowledge of the reproductive and developmental toxicity is indicated to laboratory animals, in addition, about a lead (inorganic lead compound), in ACGIH-TLV (2005), Proposition 65 (California EPA, 2005), ATSDR (draft, 2005), etc., was indicated reproductive toxicity to humans. So it was considered as Category 1B. | |
8 | Specific target organ toxicity - Single exposure | Category 2 (central nervous system, digestive system, cardiovascular system, kidney), Category 3 (respiratory tract irritation) | Warning |
H371: May cause damage to organs (central nervous system, digestive system, cardiovascular system, kidney) H335: May cause respiratory irritation (respiratory tract irritation) |
P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P405: Store locked up. P501: Dispose of contents/container to ... P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P312: Call a POISON CENTER or doctor/physician if you feel unwell. |
The substance was classified as Category 2 (central nervous system, gastrointestinal system, cardio-vascular system, kidneys) and Category 3 (airway irritant) based on the reports of the effects on the central nervous system, gastrointestinal system, cardio-vascular system and kidneys, and of its airway irritant properties in humans (ICSC, 1999; HSFS, 2001). | |
9 | Specific target organ toxicity - Repeated exposure | Category 2 (skin, blood, cardiovascular system, kidney, liver, nervous system) | Warning | H373: May cause damage to organs through prolonged or repeated exposure (skin, blood, cardiovascular system, kidney, liver, nervous system) |
P260: Do not breathe dust/fume/gas/mist/vapours/spray. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ... |
It was classified into Category 2 (the skin, blood, a cardiovascular systems, the kidney, liver, nervous system) based on the description that the influence on skin, mucosa, marrow, blood, cardiovascular systems, kidney, liver, and a nervous system to humans (ICSC, 1999;HSFS, 2001). | |
10 | Aspiration hazard | Classification not possible | - | - | - | - | No data available |
Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment (Acute) | Classification not possible | - | - | - | - | No data available |
11 | Hazardous to the aquatic environment (Long-term) | Classification not possible | - | - | - | - | No data available. |
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference Manual |
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Definitions / Abbreviations |
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Model Label by MHLW |
MHLW Website (in Japanese Only) |
Model SDS by MHLW |
MHLW Website (in Japanese Only) |