Chemical Name:2,3-dihydro-2,2-dimethyl-7-benzofuryl 2,4-dimethyl-6-oxa-5-oxo-3-thia-2,4-diazadecanoate
CAS:65907-30-4
ID: | 1095 |
Classifier: | Inter-ministerial Committee on GHS |
Year Classified: | FY2006 |
Reference Manual: | GHS Classification Manual (10 Feb, 2006) |
Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
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1 | Explosives | Not applicable | - | - | - | - | There are no chemical groups associated with explosive properties present in the molecules. |
2 | Flammable gases (including chemically unstable gases) | Not applicable | - | - | - | - | Solid (GHS definition) |
3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products |
4 | Oxidizing gases | Not applicable | - | - | - | - | Solid (GHS definition) |
5 | Gases under pressure | Not applicable | - | - | - | - | Solid (GHS definition) |
6 | Flammable liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
7 | Flammable solids | Classification not possible | - | - | - | - | No data available |
8 | Self-reactive substances and mixtures | Not applicable | - | - | - | - | There are no chemical groups associated with explosive or self-reactive properties present in the molecule. |
9 | Pyrophoric liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
10 | Pyrophoric solids | Classification not possible | - | - | - | - | No data available |
11 | Self-heating substances and mixtures | Classification not possible | - | - | - | - | The test suitable for the solid of 140 degC or less of melting points is not established. (42.6 - 45.7 degC melting points) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | - | The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
13 | Oxidizing liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
14 | Oxidizing solids | Not applicable | - | - | - | - | Organic compounds containing oxygen (but not chlorine and fluorine) and the oxygen is chemically bonded only to carbon (but not to other elements). |
15 | Organic peroxides | Not applicable | - | - | - | - | Organic compounds containing no -0-0- structure |
16 | Corrosive to metals | Classification not possible | - | - | - | - | No data available (Melting point: 42.6-45.7degC) |
Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
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1 | Acute toxicity (Oral) | Category 2 | Danger | H300: Fatal if swallowed |
P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment (see ... on this label). P330: Rinse mouth. P405: Store locked up. P501: Dispose of contents/container to ... |
Among three LD50 value of oral administration examination for male and female rats (Agricultural Chemical Registration Data), the lower value of LD50=10 mg/kg was adopted to classify as category 2. | |
1 | Acute toxicity (Dermal) | Category 5 | - | Warning | H313: May be harmful in contact with skin | P312: Call a POISON CENTER or doctor/physician if you feel unwell. | It was set as Category 5 based on rat LD50 = 2020mg/kg of the dermal administration test (Agricultural Chemical Registration Data). |
1 | Acute toxicity (Inhalation: Gases) | Not applicable | - | - | - | - | Solid (GHS definition) |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible | - | - | - | - | No data available |
1 | Acute toxicity (Inhalation: Dusts and mists) | Category 2 | Danger | H330: Fatal if inhaled |
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P284: Wear respiratory protection. P310: Immediately call a POISON CENTER or doctor/physician. P320: Specific treatment is urgent (see ... on this label). P405: Store locked up. P501: Dispose of contents/container to ... |
It was set as Category 2 based on LC50 = 0.24mg/L.: this is the lower value of LC50 = 0.24mg/L. and LC50 = 0.16mg/L (Agricultural Chemical Registration Data) by the inhalation exposure test using rats. | |
2 | Skin corrosion/irritation | Classification not possible | - | - | - | - | No data available |
3 | Serious eye damage/eye irritation | Classification not possible | - | - | - | - | No data available |
4 | Respiratory sensitization | Classification not possible | - | - | - | - | No data available |
4 | Skin sensitization | Category 1 | Warning | H317: May cause an allergic skin reaction |
P302+P352: IF ON SKIN: Wash with plenty of soap and water. P333+P313: If skin irritation or rash occurs: Get medical advice/attention. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P272: Contaminated work clothing should not be allowed out of the workplace. P280: Wear protective gloves/protective clothing/eye protection/face protection. P321: Specific treatment (see ... on this label). P363: Wash contaminated clothing before reuse. P501: Dispose of contents/container to ... |
It was referred to as Category 1 based on the publication (Agricultural Chemical Registration Data) that the positive result was obtained in the skin sensitivity test using a guinea pig. | |
5 | Germ cell mutagenicity | Not classified | - | - | - | - | There is no data of human administration cost epidemiology, an administration cost mutagenicity test, and a productive cell in vivo mutagenicity test. And there is the statement (Agricultural Chemical Registration Data) with negativity in the somatic cell in vivo mutagenicity test (micronucleus test which used mouse bone marrow cells). So it carried out the outside of Category. |
6 | Carcinogenicity | Not classified | - | - | - | - | In the carcinogenicity tests using rat and mouse, based on the description that there is no treatment-related tumorigenesis (Agricultural Chemical Registration Data), it was out of the Category . |
7 | Reproductive toxicity | Not classified | - | - | - | - | In the two-generation reproductive examination using rats and the teratogenicity study using rats and rabbits, it was carried out the outside of Category based on the description that reproductive toxicity was not acknowledged (Agricultural Chemical Registration Data). |
8 | Specific target organ toxicity - Single exposure | Category 1 (systemic toxicity, nervous system) | Danger | H370: Causes damage to organs (systemic toxicity, nervous system) |
P307+P311: IF exposed: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment (see ... on this label). P405: Store locked up. P501: Dispose of contents/container to ... |
There is a report that symptoms, such as decrease in locomotor activity, motor ataxia, tremors, bloody tears, contraction of the pupil, protrusion of the eyeballs, gasping, lacrimation, convulsions, excessive urination, dyspnea, salivation, swelling of the neck, marks of bite wounds on the tongue, nasal discharge and bleeding in the mouth, were observed at the dosages (5.9-186.0mg/kg) within the guidance values of Category 1 (Agricultural Chemical Registration Data). It is also reported that symptoms, such as locomotor activity, motor ataxia, tremors, lacrimation, convulsions, excessive urination and salivation, were observed at the dosages (8.0-253.0mg/kg) within the guidance values for Category 1 (Agricultural Chemical Registration Data). The substance was classified as Category 1 (systemic, nervous system) based on this information. | |
9 | Specific target organ toxicity - Repeated exposure | Category 1 (blood), Category 2 (nervous system) |
Danger Warning |
H372: Cause damage to organs through prolonged or repeated exposure (blood) H373: May cause damage to organs through prolonged or repeated exposure (nervous system) |
P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ... |
It was classified into Category 1 (blood) and Category 2 (nerve systems) based on the descriptionthat in a rat, with the dose (6.95-8.38 mg/kg) of guidance value within the range of guidance value in Category 1, inhibition of plasma, red blood cell and brain cholinesterase, and tendency toward anemia were observed, and in the dose (36.81 mg/kg) within the range of guidance value in Category 2, the decreased weight gains, consumption decreases, inhibtion of plasma, red blood cell and brain cholinesterase, and an tendency toward anemia were observed (pesticide registration application documents) . | |
10 | Aspiration hazard | Classification not possible | - | - | - | - | No data available |
Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment (Acute) | Category 1 | Warning | H400: Very toxic to aquatic life |
P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ... |
It was classified into Category 1 from 48-hour LC50=1.8microg/L of Crustacea (Water fleas) (HSDB, 2004). | |
11 | Hazardous to the aquatic environment (Long-term) | Category 1 | Warning | H410: Very toxic to aquatic life with long lasting effects |
P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ... |
Classified into Category 1, since acute toxicity is Category 1, supposed not rapidly degrading (BIOWIN), and bioaccumulative (log Kow=4.7 (PHYSPROP Database, 2005)). |
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference Manual |
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Definitions / Abbreviations |
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Model Label by MHLW |
MHLW Website (in Japanese Only) |
Model SDS by MHLW |
MHLW Website (in Japanese Only) |