NITE - Chemical Management Field

GHS Classification Result

Chemical Name：Sodium chlorite
CAS：7758-19-2

Result：


ID:	1109
Classifier:	Inter-ministerial Committee on GHS
Year Classified:	FY2006
Reference Manual:	GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Explosives	Not classified	-	-	-	-	Not classified based on UNRTDG No. 1496, Class: 5.1, PGIII, though containing O-Halogen bonds as chemical groups associated with explosive properties present.
2	Flammable gases （including chemically unstable gases）	Not applicable	-	-	-	-	Solid (GHS definition)
3	Aerosols	Not applicable	-	-	-	-	Not aerosol products
4	Oxidizing gases	Not applicable	-	-	-	-	Solid (GHS definition)
5	Gases under pressure	Not applicable	-	-	-	-	Solid (GHS definition)
6	Flammable liquids	Not applicable	-	-	-	-	Solid (GHS definition)
7	Flammable solids	Not classified	-	-	-	-	Non-combustible (ICSC (J) (2000))
8	Self-reactive substances and mixtures	Not applicable	-	-	-	-	Classified in oxidizing solids
9	Pyrophoric liquids	Not applicable	-	-	-	-	Solid (GHS definition)
10	Pyrophoric solids	Not classified	-	-	-	-	Non-combustible (ICSC (J), 2000)
11	Self-heating substances and mixtures	Not classified	-	-	-	-	Not combustible (ICSC(J) (2000))
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified	-	-	-	-	Stable to water (the water solubility is obtained)
13	Oxidizing liquids	Not applicable	-	-	-	-	Solid (GHS definition)
14	Oxidizing solids	Category 2		Danger	H272: May intensity fire; oxidizer	P370+P378: In case of fire: Use ... for extinction. P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking. P220: Keep/Store away from clothing/.../combustible materials. P221: Take any precaution to avoid mixing with combustibles/... P280: Wear protective gloves/protective clothing/eye protection/face protection. P501: Dispose of contents/container to ...	UNRTDG No. 1496, Class: 5.1; PG II.
15	Organic peroxides	Not applicable	-	-	-	-	Inorganic compound
16	Corrosive to metals	Classification not possible	-	-	-	-	Test methods applicable to solid substances are not available.

HEALTH HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Acute toxicity （Oral）	Category 3		Danger	H301: Toxic if swallowed	P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P330: Rinse mouth. P405: Store locked up. P501: Dispose of contents/container to ...	We had two LD50 values in rats, 350mg/kg and 165mg/kg (RTECS(2003)), so we adopted 165mg/kg which is the higher toxicity value, and classified the substance as Category 3.
1	Acute toxicity （Dermal）	Category 2		Danger	H310: Fatal in contact with skin	P302+P350: IF ON SKIN: Gently wash with plenty of soap and water. P262: Do not get in eyes, on skin, or on clothing. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P280: Wear protective gloves/protective clothing/eye protection/face protection. P310: Immediately call a POISON CENTER or doctor/physician. P322: Specific treatment （see ... on this label）. P361: Remove/Take off immediately all contaminated clothing. P363: Wash contaminated clothing before reuse. P405: Store locked up. P501: Dispose of contents/container to ...	The purity reduced values of LD50 values are rabbit 107.2mg/kg (=1340.8) and rat 157.5mg/kg (=3150.5) of IUCLID (2000). High purity with high toxicity of 107.2mg/kg was adopted, and it was set as Category 2.
1	Acute toxicity （Inhalation: Gases）	Not applicable	-	-	-	-	Solid (GHS definition)
1	Acute toxicity （Inhalation: Vapours）	Classification not possible	-	-	-	-	No data. (It is a solid. But there is no vapor pressure information, and it is unknown whether exposure to vapor is possible.)
1	Acute toxicity （Inhalation: Dusts and mists）	Category 2		Danger	H330: Fatal if inhaled	P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P284: Wear respiratory protection. P310: Immediately call a POISON CENTER or doctor/physician. P320: Specific treatment is urgent （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ...	Since there are two rat LC50 values: 0.23mg/L (the original is 230mg/m3) (RTECS (2003)) and purity equivalent 0.235mg/L (=0.29*0.809) (IUCLID (2000)), 0.23mg/L of higher toxicity was adopted and set to category 2.
2	Skin corrosion/irritation	Category 2		Warning	H315: Causes skin irritation	P302+P352: IF ON SKIN: Wash with plenty of soap and water. P332+P313: If skin irritation occurs: Get medical advice/attention. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection. P321: Specific treatment （see ... on this label）. P362: Take off contaminated clothing and wash before reuse.	The data (which is weak stimulative) of ECETOC TR66 (1995) in the rabbit corresponds to category 3. But it was set as category 2 since comparatively stronger stimulativeness could be considered from "a stimulus and chemical burn" (HSFS (2000)) and "a strong stimulative" (HSDB (2002)) in the human impact.
3	Serious eye damage/eye irritation	Category 2A-2B		Warning	H319: Causes serious eye irritation	P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313: If eye irritation persists: Get medical advice/attention. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection.	There is the descriptions in human effects (having irritation) (ICSC(J)(2000), HSFS(2000), HSDB(2002)), and two data in rabit (having irritation) (IUCLID(2000)), it is clear its irritation. Since the examination data used as the index of subdivision was not found in IUCLID, it was classified into Category 2A-2B. [Indication] 2A is recommended based on the safety, when the Category needs to subdivide.
4	Respiratory sensitization	Classification not possible	-	-	-	-	No data available
4	Skin sensitization	Classification not possible	-	-	-	-	No data available
5	Germ cell mutagenicity	Category 2		Warning	H341: Suspected of causing genetic defects	P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ...	It was set as Category 2 from the positive example (oral administration negative) by the medication in the abdominal cavity in the in vivo small core examination of a mouse (IARC52 (1991), IRIS (2000)).
6	Carcinogenicity	Not classified	-	-	-	-	Based on the classification (Group 3) in IARC52 (1991) and (D) in IRIS (2000), it was out of the Category.
7	Reproductive toxicity	Not classified	-	-	-	-	From the description in rat and mouse "the slightly impact on reproductive was observed"(IARC52 (1991)), it is thought that reproductive toxicity is slight, and in the report of the rabbit of ATSDR (2004), some findings are observed but it does not think that it relate to administration directly, in addition, there was description that "there was no evidence of reproductive toxicity" in rat (JAT (2000) (RTECS (2003) original literature of prescription data), it carried out the outside of Category.
8	Specific target organ toxicity - Single exposure	Category 2 (respiratory system, kidney)		Warning	H371: May cause damage to organs (respiratory system, kidney)	P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P405: Store locked up. P501: Dispose of contents/container to ...	The substance was classified as Category 2 (respiratory system, kidneys) because of the reports of the effects (cyanosis resulting from the effects on the respiratory system, renal failure) on humans in RTECS (2003), in Priority 2, and of pulmonary edema, dyspnea and airway irritant properties in HSFS (2000), and of airway irritant properties in ICSC (J) (2000).
9	Specific target organ toxicity - Repeated exposure	Category 2 (heart, blood)		Warning	H373: May cause damage to organs through prolonged or repeated exposure (heart, blood)	P260: Do not breathe dust/fume/gas/mist/vapours/spray. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ...	It was classified into Category 2 (heart, blood) based on the description of ATSDR (2004)(Priority 1) (influence on the significant blood in administration) and the description of RTECS (2003)(Priority 2) (cardiomyopathy) in rat, and the dose of each toxic view.
10	Aspiration hazard	Classification not possible	-	-	-	-	No data available

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
11	Hazardous to the aquatic environment （Acute）	Category 1		Warning	H400: Very toxic to aquatic life	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	It was classified into Category 1 from 48-hour EC50=0.0146ppm of EC of Crustacea (Daphnia magna) (AQUIRE, 2003).
11	Hazardous to the aquatic environment （Long-term）	Category 1		Warning	H410: Very toxic to aquatic life with long lasting effects	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	Classified into Category 1, since acute toxicity was Category 1, and behavior in water and bioaccumulative potential are unknown.

NOTE:

* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：

Reference Manual
Definitions / Abbreviations
Model SDS by MHLW	MHLW Website （in Japanese Only）