GHS Classification Result

Chemical Name：anilinium chloride
CAS：142-04-1

Result：
ID: 1114
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Not classified - - - - Although it is flammable, UNRTDG is classified into 6.1 and III according to the UNRTDG No.(1548). Since 4.1 was not assigned, it was classified as out of Category.
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - Not classified because of UNRTDG No. 1548, Class: 6.1, III (not Class: 4.2)
11 Self-heating substances and mixtures Not classified - - - - UNRTDG is classified into 6.1 and III according to the U.N. number (1548) peculiar to a substance. Since 4.2 was not attached, it carried out the outside of Category.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not classified - - - - UNRTDG No. 1548, Class: 6.1; PG III (Not 5.1).
15 Organic peroxides Not applicable - - - - Organic compounds containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		Because the LD50 in rats was 840mg/kg (RTECS (2004)), the substance was classified as Category 4. [Note] Since there may be information about aniline instead of aniline hydrochloride, also refer to aniline (ID_No. 0007, CAS_No. 62-53-3) for the following items related to health hazards.
1 Acute toxicity （Dermal） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Solid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P362: Take off contaminated clothing and wash before reuse. 		It was set as Category 2 from the description that there is irritation to humans (Moderate, RTECS (2004)), and the result that Standard Draize Test to rabbit (ICSC (J), (2001), HSFS (2003)).
3 Serious eye damage/eye irritation Category 2A-2B Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection. 		Due to the descriptions that it irritates to human eyes, and that the result of Standard Draize Test of aniline hydrochloride using the rabit (Moderate, RTECS (2004)), it was classified into Category 2A-2B. In addition, although it correspond to R41 (severe damages on the eye) in the EU risk epigram, this was classified based on the evaluations to anilines, and the information about aniline hydrochloride was restricted. Therefore, it was not made into the classified evidence. [Indication] 2A is recommended based on the safety, when the Category needs to subdivide.
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Classification not possible - - - - Although there is description (sensitization of the skin may be carried out by repetition or long-term contactICSC(J)(2001)) which suggests skin sensitization, there is no data which meets the classification standards of GHS, and since data is insufficient, it cannot classify.
5 Germ cell mutagenicity Category 2 Warning H341: Suspected of causing genetic defects P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Although each is negative (IARC 27 (1982), EU-RAR (2004)) in the in vivo chromosomal aberration test using rat myeloid and mouse cells, a positive result is accepted in the in vivo small core examination using rat myeloid and mouse cells (EU-RAR (2004)). If it classifies based on technical guidelines flow from the above result, it can classify with Category 2. Furthermore, in evaluation of EU-RAR to aniline (the result of aniline hydrochloride is also used in part), they are Category 3 and the risk phrases R68, and this is also equivalent to the Category 2 of a GHS classification. So it is judged that Category 2 is appropriate.
6 Carcinogenicity Category 2 Warning H351: Suspected of causing cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		It is categorized into Group 3 which corresponds to outer GHS Category as anilines and aniline hydrochloride in IARC (IARC 27(1982); IARC Suppl.7 (1987)). But it is categorized into Category 3 which corresponds to GHS Category 2 as aniline according to evaluation of the latest EU (EU-RAR (2004)). So it was classified into Category 2. In addition, the carcinogenicity tests in NTP (NTP TR-130 (1978)) is performed using aniline hydrochloride, and negative result in mouse and positive result in rat are obtained. IARC and EU use this evaluation.
7 Reproductive toxicity Classification not possible - - - - Although there is a report (EU-RAR (2004), Catalog of Teratogenic Agents, 11th ed. (2004)) that the effect originating in the blood poison to dam of aniline hydrochloride arises in fetus by administration to pregnant female rats, there is no fertility data. And data is insufficient, it cannot classify.
8 Specific target organ toxicity - Single exposure Category 2 (blood), Category 3 (respiratory tract irritation) Warning H371: May cause damage to organs (blood)
H335: May cause respiratory irritation (respiratory tract irritation) 		P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P405: Store locked up.
P501: Dispose of contents/container to ...
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell. 		The substance was classified as Category 2 (blood) and Category 3 (airway irritant) based on the reports in Priority 2 (ICSC (J) (2001), HSFS (2003)) that"it causes irritation to airways, and may affect the blood and form methemoglobin" in humans.
9 Specific target organ toxicity - Repeated exposure Category 2 (blood, spleen, testis) Warning H373: May cause damage to organs through prolonged or repeated exposure (blood, spleen, testis) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		Since in Priority2, within the range of the guidance value which is classified into Category 2, the effect on spleen, testis and blood of male rats (RTECS (2004)) and human blood is affected (ICSC (J), (2001)), it was classified into Category 2 (blood,spleen,teste).
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Classification not possible - - - - Insufficient data available.
11 Hazardous to the aquatic environment （Long-term） Classification not possible - - - - Classification not possible due to lack of data


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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