GHS Classification Result

Chemical Name：4-[(Hydroxy)(methyl)phosphinyl]-L-Abu-L-Ala-L-Ala-ONa
CAS：71048-99-2

Result：
ID: 1116
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Classification not possible - - - - No data available
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - Non-pyrophoric when in contact with air at a room temperature and used as agricultural chemicals.
11 Self-heating substances and mixtures Classification not possible - - - - No data available
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified - - - - Stable to water. (The value of aqueous solubility is acquired. Moreover, as pesticide, many are produced commercially as a water-soluble powders.)
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Classification not possible - - - - No data available
15 Organic peroxides Not applicable - - - - Organic compounds containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 3 Danger H301: Toxic if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Because the LD50 in rats was 268mg/kg (RTECS (2004), the Journal of Pesticide Science (1987)), the substance was classified as Category 3.
1 Acute toxicity （Dermal） Category 5 - Warning H313: May be harmful in contact with skin P312: Call a POISON CENTER or doctor/physician if you feel unwell. It was set as Category 5 based on rat LD50 = 3g/kg (RTECS (2002) and Pesticide Science Society of Japan (1987)).
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Solid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - Rat LC50 value in inhalation is 2570mg/m3 (= 2.57mg/L, RTECS, 2002; Pesticide Science Society of Japan, 1987). But there was no description of steam or dust/mist, and also no vapor pressure data. It could not judge to be either, so it was presupposed that it cannot be classified due to data insufficiency. In addition, it is Category 3 if it is assumed to be steam, and it is Category 4 if it is assumed to be dust/mist.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - Rat LC50 value in inhalation is 2570mg/m3 (= 2.57mg/L, RTECS, 2002; Pesticide Science Society of Japan, 1987). But there was no description of steam or dust/mist, there was also no vapor pressure data, and it could not be judged either one. Therefore, it cannot be classifid since data was insufficient. In addition, it corresponds to category 3 if it assumes that it is steam, and category 4 if it assumes to be dust/mist.
2 Skin corrosion/irritation Not classified - - - - Since block paste of 0.5g of this product did not indicate irritation to the rabbit skin (Pesticide Science Society of Japan, 1987), it carried out the outside of Category.
3 Serious eye damage/eye irritation Category 2B - Warning H320: Causes eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling. 		Although the result of administeration to the rabbit eye of 0.1g of this product showed very slight stimulativeness, but it recovered after 48 hours (Pesticide Science Society of Japan, 1987). Therefore, it was classified into Category 2B.
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ... 		Since very slight causing sensitivity was acknowledged in the quality of a genuine article (Pesticide Science Society of Japan, 1987) with the Draize method using a guinea pigs, the ratio of the positive animal was set to Category 1 though it was unknown. In addition, the 20% water-soluble powders of this product did not indicate sensitizing by the maximization method which used the guinea pigs (Pesticide Science Society of Japan, 1987).
5 Germ cell mutagenicity Classification not possible - - - - Although it is negative in the in vitro mutagenicity test (Ames examination, and in vitro chromosomal aberration test) (Pesticide Science Society of Japan, 1987), there is no in vivo mutagenicity test data. So it cannot taxonomic according to lack of data.
6 Carcinogenicity Not classified - - - - In chronic toxicity and carcinogenicity test in rat and mouse, significant development of tumor was not observed (Journal of Pesticide Sci. Soc. of Japan, 1987). So it was out of Category.
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		In the effect test exerted on the next-generation using a rat (generation reproduction and teratogenicity), delayed ossification and decreasing in fetus weight was seen in the dose which indicated maternal toxicity (Pesticide Science Society of Japan (1987)), so it was set as Cayegory 2. On the other hand, in the teratogenicity study using rat and rabbit, it was negative (Pesticide Science Society of Japan (1987)).
8 Specific target organ toxicity - Single exposure Category 1 (central nervous system) Danger H370: Causes damage to organs (central nervous system) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		The substance was classified as Category 1 (central nervous system) because in a report which is equivalent to a Priority 1 document, there are inertia, salivation, clonic convulsions and increased irritability to outside stimuli in a rat acute oral administration test at the dosages within the guidance values (=<300mg/kg) of Category 1(Pesticide Science Society of Japan, 1987) .
9 Specific target organ toxicity - Repeated exposure Not classified - - - - Although in a document equivalent to priority 1, hypertrophy of the renal proximal tubule and the increase of kidney weights were observed in the subacute toxicity study for three months and the chronic toxicity and carcinogenicity test for 24 months of a rat, since degenerative change except renal dysfunction and increase of an smooth endoplasmic reticulum was not observed (Pesticide Science Society of Japan, 1987), it considered as the outside of Category.
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Classification not possible - - - - No data available
11 Hazardous to the aquatic environment （Long-term） Classification not possible - - - - No data available.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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