GHS Classification Result

Chemical Name:Uranyl acetate dihydrate
CAS:6159-44-0

Result:
ID: 1130
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual (10 Feb, 2006)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Not classified - - - - HSDB (2005) has the statement that the anhydride of this substance is "almost nonflammable" and it was classified as out of Category.
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - HSDB(2005) has a description that the anhydride of the this substance is "almost nonflammable", and it was defined as "out of Category".
11 Self-heating substances and mixtures Not classified - - - - HSDB (2005) has the description that the anhydride of the this product "is mostly nonflammable", and it was set to the outside of category.
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified - - - - Stable to water (soluble in water)
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Classification not possible - - - - No data available
15 Organic peroxides Not applicable - - - - Organic compounds containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 3 Danger H301: Toxic if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ...
Category 3 based on SPECIES: Rat; ENDPOINT: LD50; VALUE: 204 mg/kg; REFERENCE SOURCE: RTECS(1998)
1 Acute toxicity (Dermal) Classification not possible - - - - No data available
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Solid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - No data available
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment (see ... on this label).
P362: Take off contaminated clothing and wash before reuse.
Since there was description that human skin is stimulated (HSDB (2002)), it was set as 2.
3 Serious eye damage/eye irritation Category 2A-2B Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
Due to the description that it irritates to human eye (HSDB(2002)), it was classified into Category 2A-2B. In addition, it is difficult to subdivide the Category of this data.
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Classification not possible - - - - No data available
5 Germ cell mutagenicity Category 2 Warning H341: Suspected of causing genetic defects P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
Since the chromosomal abnormalities was acknowledged in the uranium compounds in peripheral lymphocyte of workers by which occupational exposure was carried out (PATTY (5th, 2001)), it was set as Category 2 according to classification guidelines.
6 Carcinogenicity Category 1A Danger H350: May cause cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
As uranium and its soluble and insoluble compounds, it was categorized into A1(IARC78 (2001)) in ACGIH, and as radionuclide which depoited in the body, it was categorized into 1 in A1 (ACGIH (7th, 2001)). So it was classified into Category 1A.
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
In administration in pregnant perinatal mice test, falling of average number of child, survival rates, childcare rate and pregnancy rate was observed (the toxicity to parent animals is unknown) and in tetis toxicity study and a mating trials with the non-taken female, the effects of father animal tetis was acknowledged only the highest concentrations. However, the thing for which the significant decline in a pregnancy rate was acknowledged in all 4 dose although there was no dose-dependent (toxicity to a father animal was only acknowledged by highest dosesignificant as weight decrease), (all PATTY(s) (5th, 2001)). And the dose which maternal toxicity (decrease of weight and intakes) is regarded as a teratogenicity study, increase of cleft palates and skeletal mutation was acknowledged (Catalog of teratogenic agents (2004), RTECS (1998)). So it was set as Category 2.
8 Specific target organ toxicity - Single exposure Category 1 (kidney), Category 3 (respiratory tract irritation) Danger
Warning
H370: Causes damage to organs (kidney)
H335: May cause respiratory irritation (respiratory tract irritation)
P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
The substance was classified as Category 1 (kidneys) because there is a report in Priority 1 of the effects on the kidneys, such as necrosis of the proximal convoluted tubules and collecting tubules, after exposure to the uranium compound in humans (ACGIH (7th, 2001)). The substance was also classified as Category 3 (airway irritant) because its dust causes irritation to nose and throat (HSDB (2002)).
9 Specific target organ toxicity - Repeated exposure Category 1 (kidney) Danger H372: Cause damage to organs through prolonged or repeated exposure (kidney) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
Since there is description that the major target organ of the chronic toxicity in a uranium compound was the kidney (mainly proximal tubule) (in Priority 1,ACGIH (7th, 2001)), it was classified into Category 1 (kidney).
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Classification not possible - - - - No data available
11 Hazardous to the aquatic environment (Long-term) Classification not possible - - - - No data available.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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