Chemical Name：isopropyl 3-[[(ethylamino)methoxyphosphinothioyl]oxy]crotonate
CAS：31218-83-4

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Acute toxicity （Oral）	Category 3		Danger	H301: Toxic if swallowed	P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P330: Rinse mouth. P405: Store locked up. P501: Dispose of contents/container to ...	When we compared the LD50 values for male and female rats in two Oral Toxicity tests, the values were LD50 = 94.2mg/kg and LD50 = 96.4mg/kg respectively (drug application materials). Based on the lower of these two values, the substance was classified as Category 3.
1	Acute toxicity （Dermal）	Category 3		Danger	H311: Toxic in contact with skin	P302+P352: IF ON SKIN: Wash with plenty of soap and water. P280: Wear protective gloves/protective clothing/eye protection/face protection. P312: Call a POISON CENTER or doctor/physician if you feel unwell. P322: Specific treatment （see ... on this label）. P361: Remove/Take off immediately all contaminated clothing. P363: Wash contaminated clothing before reuse. P405: Store locked up. P501: Dispose of contents/container to ...	Based on lower rabbit LD50 = 486.4mg/kg (application documents for United States pesticide registration) among LD50s of rat and rabbit, it was set as Category 3.
1	Acute toxicity （Inhalation: Gases）	Not applicable	-	-	-	-	Liquid (GHS definition)
1	Acute toxicity （Inhalation: Vapours）	Classification not possible	-	-	-	-	No data available
1	Acute toxicity （Inhalation: Dusts and mists）	Category 4		Warning	H332: Harmful if inhaled	P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P312: Call a POISON CENTER or doctor/physician if you feel unwell.	If the lower one is taken among rat LC50 values of both sex in 4-hour inhalation toxicity study , they are LC50 = 3.02mg/L and LC50 = 3.3mg/L, respectively (drugs application materials). And it was set as Category 4 based on the lowest value LC50=3.02 mg/L..
2	Skin corrosion/irritation	Not classified	-	-	-	-	It carried out the outside of Category based on the description that each of erythema / crusta, or average scores of dropsy are less than 1.5 in two examinations in rabbits (drugs application materials, United States pesticide registration application documents).
3	Serious eye damage/eye irritation	Not classified	-	-	-	-	There is the descriptions in two examinations in the rabbit that acne cornea or opacity are not observed, iris is normal, no affluxion and edema are observed in conjunctiva (the documents of approval of new drug applications, the documents of United States registration application of insecticide). So it was not classified.
4	Respiratory sensitization	Classification not possible	-	-	-	-	No data available
4	Skin sensitization	Not classified	-	-	-	-	With the positive rate is 20% (drugs application materials) in the skin sensitization study (with adjuvant) by the Maximization method using a guinea pig, and the delayed hypersensitivity reaction examination results (without adjuvant) by the Buehler method, it is based on the description (United States pesticide registration application documents) that it is negative, it carried out the outside of Category.
5	Germ cell mutagenicity	Not classified	-	-	-	-	There is no data of human administration cost epidemiology, an administration cost mutagenicity test, and a productive cell in vivo mutagenicity test. Based on the statement (United States pesticide registration application documents) with negativity by the somatic cell in vivo mutagenicity test (in vivo chromosomal aberration test using the bone marrow cells of a rat). So it carried out the outside of Category.
6	Carcinogenicity	Not classified	-	-	-	-	Since in carcinogenicity test in rat and mouse treatment-related increased tumor was not observed (documents of approval of drug applications, documents of United States pesticide registration application), it was out of Category.
7	Reproductive toxicity	Not classified	-	-	-	-	In the reproduction test of a rat, effect of reproduction of dam and childcare, next-generation growth, development, and reproduction is not admitted by medication of the certain intoxicating dose in before pregnancy and beginning pregnancy, an organic formative period, a perinatal period, and the lactation period. But there is a description (drugs regulatory filing documents and U.S. pesticide registration application documents) that teratogenicity was not admitted by medication of the certain intoxicating doseb in teratogenicity test of rabbit. Based on the above mentioned description, it carried out the outside of Category.
8	Specific target organ toxicity - Single exposure	Category 1 (systemic toxicity, nervous system)		Danger	H370: Causes damage to organs (systemic toxicity, nervous system)	P307+P311: IF exposed: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ...	Symptoms, such as decrease in locomotor activity, ataxic gait, gait difficulty, tremors, lacrimation, salivation, constriction of the pupils, irregular breathing and convulsions, were observed in single-dose studies in rats and mice. The substance was classified as Category 1 (systemic, nervous system) based on the report that all those symptoms were observed at dosages (62.4-116.1mg/kg or 1.1-8.6mg/L) within the guidance values for Category 1 (drug application materials, U.S insecticide registration application materials).
9	Specific target organ toxicity - Repeated exposure	Classification not possible	-	-	-	-	It was considered that it cannot be classified based on the description that although in oral administration with the dose (0.34-0.70 mg/kg) of guidance value within the range of Category 1 to a rat, or in oral administration with the dose (0.176-0.692 mg/kg) of guidance value within the range of Category 1 to dog, inhibition of hemocyte and brain cholinesterase activity were observed and other toxic phenomena were not observed (documents of applications for drugs, registration application for pesticide in United States).
10	Aspiration hazard	Classification not possible	-	-	-	-	No data available

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
11	Hazardous to the aquatic environment （Acute）	Category 1		Warning	H400: Very toxic to aquatic life	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	It was classified into Category 1 from 48-hour LC50=0.0033mg/L of Crustacea (Daphnia magna), and others (the examination for the U.S. insecticide application, 1990) .
11	Hazardous to the aquatic environment （Long-term）	Category 1		Warning	H410: Very toxic to aquatic life with long lasting effects	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	Classified into Category 1, since acute toxicity was Category 1, supposed not rapidly degrading (BIOWIN), though supposed less bioaccumulative (log Kow=3.82(PHYSPROP Database, 2005)).