GHS Classification Result

Chemical Name:C.I. Pigment Red 104
CAS:12656-85-8

Result:
ID: 1173
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual (10 Feb, 2006)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Not classified - - - - Non-combustible (BGIA, GESTIS-database on hazardous substancess, Accessed in 2006)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - Non-combustible (BGIA, GESTIS-database on hazardous substancess, Accessed in 2006)
11 Self-heating substances and mixtures Not classified - - - - Non-combustible (GESTIS-database on hazardous substances, accessed in 2006)
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified - - - - Stable to water (the water solubility is obtained)
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Classification not possible - - - - No data available
15 Organic peroxides Not applicable - - - - Inorganic compound
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Not classified - - - - SPECIES: Rat ENDPOINT: LD50 VALUE: > 5000 mg/kg REFERENCE SOURCE: IUCLID (2000)
1 Acute toxicity (Dermal) Classification not possible - - - - No data available
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Solid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - No data available
2 Skin corrosion/irritation Classification not possible - - - - There is the test using a rabbit that reports "there is no irritation"(IUCLID (2000)). But it cannot be classified since the detail were not understood and the data is insufficient.
3 Serious eye damage/eye irritation Classification not possible - - - - Although there is the description that "it has no irritation" in the test using rabbit (IUCLID (2000)), the details are insufficient. Hence it cannot be classified.
4 Respiratory sensitization Category 1 Danger H334: May cause allergy or asthma symptoms or breathing difficulties if inhaled P304+P341: IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342+P311: If experiencing respiratory symptoms: Call a POISON CENTER or doctor/physician.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P285: In case of inadequate ventilation wear respiratory protection.
P501: Dispose of contents/container to ...
Although there is no report of this material itself, chromium and chromium compound were classified into "the 2nd group (material considered that there is probably sensitizing to human)" in Japan Association of Industrial Health, and chromium was classified into the material with respiratory sensitization in Japanese Society of Occupational Allergy Special Committee, this product thought that it had respiratory sensitization and was set to Category 1.
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment (see ... on this label).
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ...
In Japan Society for Occupational Health, although there was no report of this material itself, since chromium and chromium compound were classified into "the 1st group (material which has sensitizing clearly to human)", this product thought that it had skin sensitization, and was set to Category 1.
5 Germ cell mutagenicity Classification not possible - - - - No data. In addition, although this product is the insoluble hexavalent chromium compounds, the mutagenicity knowledge in in vivo is indicated about many flood solubility hexavalent chromium compounds (NTP RoC (11th, 2005), IARC49 (1990), EU-RAR (2005)). Refer to potassium dichromate (ID 262, Chemical Abstracts Service:7778-50-9). Moreover, inorganic lead compounds describes that a chromosome aberration is induced to humans in ATSDR (draft, 2005), and is classified into the germ cell mutagenicities 3A (equivalent to GHS Category 1B-2) in MAK/BAT (2005).
6 Carcinogenicity Category 1A Danger H350: May cause cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
As hexavalent chromium compounds, since it was was classified K (Chromium hexavalent (VI) compounds) in NTP (2005), group 1 (Chromium(VI)) in IARC (1990), and A (Chromium(VI), Inhalation route) in EPA (1986), respectively. So it was classified into Category 1A.
7 Reproductive toxicity Category 1A Danger H360: May damage fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
Although there is no this product data, there is the description that a lead (inorganic lead compound) shows humans reproductive toxicity (ATSDR (draft, 2005), Chemically Induced Birth Defects (3rd ed, 2000)), and it was set as Category 1A due to the category of reproductive toxicity has been done also by ACGIH (ACGIH-TLV (2005)). In addition, also refer to potassium dichromate (ID 262, CAS: 7778-50-9) as reproductive toxicity of hexavalent chromium compounds.
8 Specific target organ toxicity - Single exposure Category 1 (central nervous system, blood, kidney) Danger H370: Causes damage to organs (central nervous system, blood, kidney) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
Although there is no data about this product, since "symptom that the acute influence of inorganic leads and chronic influence are almost the same is observed " about humans, as toxicity of the inorganic lead compounds (CERI Hazard Data 2001-9, 2002), in ACGIH-TLV (2005), it effects on the central nervous systems, blood, and renal as inorganic leads compound, it was considered as Category 1 (a central nervous system, blood, kidney). In addition, there is description that when oral or percutaneous absorption is carried out as acute toxicities of the hexavalent chromium compound, vomiting, diarrhea, a spasm, a hemorrhagic nephritis, etc. are caused (DFGOT vol.3 (1992), DHP (13th, 2002)). Moreover, the influence on blood (anemia) (PATTY (5th, 2001)) and respiratory irritant (HSDB (2003)) are mentioned as toxicity of molybdenum.
9 Specific target organ toxicity - Repeated exposure Category 1 (central nervous system, blood, kidney) Danger H372: Cause damage to organs through prolonged or repeated exposure (central nervous system, blood, kidney) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
Although there was no data of this product, as an inorganic lead compound, it effects on central nervous systems, blood, and kidney (ACGIH-TLV (2005) in Priority 1 document). It was classified into Category 1 (central nervous system, blood, kidney). In addition, there is a description of effects on kidneys, nasal septum perforation, ulcers, etc. as chronic toxicity of hexavalent chromium compounds (ACGIH (7th, 2001), IRIS (1998), DHP (13th, 2002)). Moreover, as toxicity of molybdenum, effects on blood (anemia) and lungs (pneumoconiosis) are mentioned (PATTY (5th, 2001), HSDB (2003)).
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Classification not possible - - - - Insufficient data available.
11 Hazardous to the aquatic environment (Long-term) Category 4 - - H413: May cause long lasting harmful effects to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ...
Classified into Category 4, since it is a metallic compound, and behavior in water is unknown, though no acute toxicity is reported within the saturated aqueous solution.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


To GHS Information