GHS Classification Result

Chemical Name：Benzene, 1-chloro-2-nitro-
CAS：88-73-3

Result：
ID: 1184
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not classified - - - - Not classified because of UNRTDG No. 1578, Class: 6.1, PG II (Not Class: 1), though the substance contains N-O bonds as chemical groups associated with explosive properties present and "There is a possibility of the dust explosion." (ICSC(J), 2002)
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Not classified - - - - Although ICSC (J) (2002) has description of "inflammability", UNRTDG is classified into 6.1 and II according to the UNRTDG No. (1578). Since 4.1 was not assigned, it was classified as out of Category.
8 Self-reactive substances and mixtures Not classified - - - - Not classified in UNRTDG Class: 4.1, but UNRTDG No. 1578, Class: 6.1, PGIII
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - Ignition temperature is 487 degC (ICSC (J), 2002), and even if it contacts the air of normal temperature, it does not ignite spontaneously.
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to solid (melting point <= 140degC) substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not applicable - - - - The organic compound which forms no chemical bond with any elements other than carbon although it contains chlorine. However, ICSC (J) (2001) has the description of a "strong oxidizer."
15 Organic peroxides Not applicable - - - - Organic compounds containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - UNRTDG is classified into 6.1 and II according to the UNRTDG No. (1578). Although 8 is not attached, since the data which negates corrosion behavior is not found, it cannot be classified.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 3 Danger H301: Toxic if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the LD50 = 203mg/kg calculated from the LD50 values in rats (251, 263, 560, 144, 270 and 268mg/kg) (SIDS (2001), DFGOT Vol.4 (1992), IARC(1996) and RTECS (2003)), the substance was classified as Category 3.
1 Acute toxicity （Dermal） Category 3 Danger H311: Toxic in contact with skin P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P322: Specific treatment （see ... on this label）.
P361: Remove/Take off immediately all contaminated clothing.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Rat LD50 = 655mg/kg (SIDS (2001)) (higher toxicity at comparison with 1320 mg/kg). And the rabbit LD50 = 376mg/kg (calculated from rabbit LD50 = 400, 445, 355, 450mg/kg (SIDS (2001), RTECS (2003))). The lower one (LD50=376 mg/kg) was adopted, and it was set as Category 3.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Solid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Dusts and mists） Category 4 Warning H332: Harmful if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell. 		It was set as Category 4 based on rat LC50 (4hr) = 495ppm (equivalent 3.18mg/L) (SIDS (2001)). In addition, the saturated concentration of this product is 24ppm, and it is presumed that the inhalation study was done in dust and mists conditions.
2 Skin corrosion/irritation Not classified - - - - One test indicated minor irritations in rabbit experiments. But it carried out the outside of category since effect was not acknowledged by two another examinations and they concluded "it had no proof of skin irritation (SIDS (2001))".
3 Serious eye damage/eye irritation Category 2B - Warning H320: Causes eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling. 		Since there were the descriptions that the slight stimulus is produced to the eye in experiments against rabbits (SIDS (2001)), and to the human eye lightly (ICSC (J), (2002)), it was classified into Category 2B.
4 Respiratory sensitization Classification not possible - - - - Although the causing sensitivity in the examination using a rat is reported (SIDS, 2001;DFGOT 4, 1992; CERI Hazard Data, 1999), since there is no knowledge to humans, data is insufficient and it cannot classify.
4 Skin sensitization Classification not possible - - - - Although the positive was obtained in the test using a guinea pig, since it had not concluded that there is finally sensitizing from information gaps (SIDS (2001)), it was presupposed that data is insufficient and it cannot classify.
5 Germ cell mutagenicity Category 2 Warning H341: Suspected of causing genetic defects P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		There is no result of in vivo mutagenicity test, and there is positive reaction (liver, kidney, brain) in the DNA damage test using mouse though it is done with the medication in the abdominal cavity. And there is the positive report in Ames test and chromosome aberration in the in vitro mutagenicity test (IARC 65 (1996); CERI Hazard Data(1999); SIDS(2001); DFGOT Vol.4(1992)). So it is classified into Category 2 according to the category flow of technical guidelines.
6 Carcinogenicity Not classified - - - - Since it was classified into Group 3 according to IARC (IARC 65 (1996)), it was out of the Category..
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		In inhalation study for rats and mice, by the level to which general toxicity appears in parental animals, the fall of male testicular weight and reduction of the sperm count were seen (CERI Hazard Data (1999); IARC 65(1996); SIDS (2001)). So it was set as Category 2.
8 Specific target organ toxicity - Single exposure Category 2 (blood) Warning H371: May cause damage to organs (blood) P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P405: Store locked up.
P501: Dispose of contents/container to ... 		It was considered as Category 2 (blood) based on the description "It effects on human blood and methemoglobin is generated" (ICSC (J) (2002)) in Priority 2.
9 Specific target organ toxicity - Repeated exposure Category 1 (blood, liver) Danger H372: Cause damage to organs through prolonged or repeated exposure (blood, liver) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		Because of the description in document of Priority 1 that effects such as increasing methemoglobin concentration and hepatocellular necrosis with concentration lower than the guidance value classified in Category 1 in the inhalation study with rats and mice (CERI Hazard Data (1999); IARC 65 (1996); SIDS (2001)), it was classified into Category 1 (blood, liver).
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		It was classified into Category 1 from 96-hour LC50=0.55 mg/L of fishes (Bluegill) (CERI Hazard Data, 1999).
11 Hazardous to the aquatic environment （Long-term） Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Classified into Category 1, since acute toxicity was Category 1, not rapidly degrading (BOD: 0% (existing chemical safety inspections data)), though less bioaccumulative (BCF=22.3 (existing chemical safety inspections data)).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

To GHS Information