Chemical Name：N1-[(6-Chloro-3-pyridyl)methyl]-N2-cyano-N1-methylacetamidine
CAS：160430-64-8

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Acute toxicity （Oral）	Category 3		Danger	H301: Toxic if swallowed	P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P330: Rinse mouth. P405: Store locked up. P501: Dispose of contents/container to ...	In two Acute Oral Toxicity tests in rats, we compared the LD50 values for male and female rats. Then for the lower of these groups we compared the LD50 values between the two tests, and selected the lower of the two. Based on the value LD50 = 146mg/kg (Agricultural Chemical Registration Data), which was the lower value of the data from the two tests, the substance was classified as Category 3.
1	Acute toxicity （Dermal）	Not classified	-	-	-	-	It was set as the outside of Category based on the description (Agricultural Chemical Registration Data) that rat dermal LD50 >2000mg/kg and there is no death.
1	Acute toxicity （Inhalation: Gases）	Not applicable	-	-	-	-	Solid (GHS definition)
1	Acute toxicity （Inhalation: Vapours）	Classification not possible	-	-	-	-	No data available
1	Acute toxicity （Inhalation: Dusts and mists）	Classification not possible	-	-	-	-	There are all 2 examinations of rat acute inhalation study. But they are not able to calculate LC50 value (EU Endpoints List Agricultural Chemical Registration Data), it cannot be classified.
2	Skin corrosion/irritation	Not classified	-	-	-	-	In the primary skin irritation test using a rabbit, it carried out the outside of Category based on the statement that there is no irritation (Agricultural Chemical Registration Data).
3	Serious eye damage/eye irritation	Not classified	-	-	-	-	Due to the description that it has no irritation in the eye irritation tests using rabbit (Agricultural Chemical Registration Data), it was set as the out of Category.
4	Respiratory sensitization	Classification not possible	-	-	-	-	No data available
4	Skin sensitization	Not classified	-	-	-	-	Based on the statement (Agricultural Chemical Registration Data) with negativity by the Maximization method of a guinea pig, it carried out the outside of Category.
5	Germ cell mutagenicity	Not classified	-	-	-	-	There is no data of human multi generation epidemiology, multi generation mutagenicity test, and germ cell in vivo mutagenicity test, and there is the description that both of the result of 2 somatic cell in vivo mutagenicity test are negative (chromosome aberration using rat bone marrow cells and small core test using mouse bone marrow cells) (Agricultural Chemical Registration Data). So it is classified as the out of the Category.
6	Carcinogenicity	Not classified	-	-	-	-	In two carcinogenicity tests in rat and mouse, based on the description that generating of treatment-related increased tumor was not observed in each examination (Agricultural Chemical Registration Data), it was out of the Category.
7	Reproductive toxicity	Not classified	-	-	-	-	By two teratogenicity tests using rats and rabbits, there is a publication that teratogenicity was not admitted by all (Agricultural Chemical Registration Data). Moreover, although there was a statement the inhibition of fetal animals' weight gains and hepatocyte hypertrophy were seen in two reproduction toxicity examinations using a rat in the dose which indicates general toxicity to parental animals, but no influence on reproduction was seen (Agricultural Chemical Registration Data, EPA FACT SHEET). The effect on a child animal was considered as a secondary effect of general toxicity on parental animals. Based on the above information, it was set as the outside of Category.
8	Specific target organ toxicity - Single exposure	Category 1 (nervous system)		Danger	H370: Causes damage to organs (nervous system)	P307+P311: IF exposed: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ...	It was considered as Category 1(nerve systems) based on the description (Agricultural Chemical Registration Data ) that tremor, squatting position, hyporeactivity, decubitus position, abdominal position, salivation, urinary incontinence, ataxy, dacryorrhea, dilatation of pupil, and clonic convulsion were observed in a rat at the dose within the range of guidance value in Category 1 (less than 300mg/kg).
9	Specific target organ toxicity - Repeated exposure	Category 2 (liver, thyroid)		Warning	H373: May cause damage to organs through prolonged or repeated exposure (liver, thyroid)	P260: Do not breathe dust/fume/gas/mist/vapours/spray. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ...	Because of the description that confirmation of increases in thyroid and liver weights, hepatocyte hypertrophy, decreased weight gain, and an increase of total cholesterol, with doses within the limits of the guidance value (10 - 100mg/kg) in Category 2 and higher in the repeated dose oral toxicity study with rats and mice (Agricultural Chemical Registration Data), it was classified into Category 2 (liver, thyroid gland).
10	Aspiration hazard	Classification not possible	-	-	-	-	No data available