GHS Classification Result

Chemical Name：1-[(6-Chloro-3-pyridyl)methyl]imidazolidine-2-(N-nitro)imine
CAS：105827-78-9

Result：
ID: 1186
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not classified - - - - Not Classified because of "The exothermic decomposition energy is lower than 300J/g and the exothermal temperature of decomposition starts lower than 500degC"(Agricultural Chemicals Registration Data, Bayer CropScience), though the substance contains nitrogen atoms adjacent to each other and N-O bonds as chemical groups associated with explosive properties present and has the oxygen balance calculated at -128.3, higher than -200 of the criteria.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Classification not possible - - - - No data available
8 Self-reactive substances and mixtures Classification not possible - - - - Classification not possible due to lack of data, though the substance contains nitrogen atoms adjacent to each other and N-O bonds as chemical groups with explosive or self-reactive properties present
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Classification not possible - - - - No data available
11 Self-heating substances and mixtures Classification not possible - - - - No data available
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Classification not possible - - - - No data available
15 Organic peroxides Not applicable - - - - Organic compounds containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available (Melting point: 144degC)

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		By the technical guidelines, we compared the LD50 values for male and female rats in two tests (Agricultural Chemical Registration Data). Then we selected the lower value for each test (424mg/kg and 410mg/kg). Based on the lower of these two values (LD50=410mg/kg), the substance was classified as Category 4.
1 Acute toxicity （Dermal） Not classified - - - - It was set as the outside of Category based on LD50 >2000mg/kg and LD50 >5000mg/kg in two rat examinations (Agricultural Chemical Registration Data).
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Solid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - There was an examination of a rat Agricultural Chemical Registration Data. But it cannot be classified since LC50 value is not acquired.
2 Skin corrosion/irritation Not classified - - - - It was carried out the outside of Category based on the statement that it did not acknowledge the skin observation in any animal in rabbit test (Agricultural Chemical Registration Data).
3 Serious eye damage/eye irritation Not classified - - - - Due to the description that ocular symptoms was not observed in each animal in rabbits test (Agricultural Chemical Registration Data), it was set as the out of Category.
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Not classified - - - - In the Maximization method using a guinea pig, based on the description (Agricultural Chemical Registration Data) that the positive rate of skin sensitization was 0%, it carried out the outside of Category.
5 Germ cell mutagenicity Not classified - - - - There is no result of human multi generation epidemiology, multi generation mutagenicity test, and germ cell in vivo mutagenicity test, and there is the description that it is negative in the somatic cell in vivo mutagenicity tet (small core test using mouse bone marrow cells) (Agricultural Chemical Registration Data). So it is classified as the out of the Category.
6 Carcinogenicity Not classified - - - - In two examinations in rat, and two examinations in mouse, due to the description that carcinogenicity was not observed in each examination (Agricultural Chemical Registration Data), It was out of the Category.
7 Reproductive toxicity Not classified - - - - Although there was a statement that inhibitation of infant's weight gains was seen in rat while infant's weight reductions and ossification delayed were seen in rabbit in the dose in which general toxicity was seen in parent animals (Agricultural Chemical Registration Data). And the other toxicity was not indicated, it was set as the outside of Category.
8 Specific target organ toxicity - Single exposure Category 1 (nervous system) Danger H370: Causes damage to organs (nervous system) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		It was considered as Category 1 (nerve systems) based on the descrption (Agricultural Chemical Registration Data ) that indifference, constrained respiration, hypomobility, transient shaking, the transient spasm, sedation, and breathing abnormality were observed in oral administration in rats at the dose within the range of guidance value in Category 1 (100mg/kg and more than 260mg/kg).
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - In rats, toxicity is not confirmed with the dosage of 60.9mg/kg within the limit of guidance value in Category 2, but with more than the dosage (300.2mg/kg), there is confirmation of decreased weight gain and effects on liver (unicellular necroses, circumscribed necroses, and round cell infiltration) (Agricultural Chemical Registration Data). Because it cannot be denied the toxicity within the guidance value limits in Category 2 for above data, no classification is available for lack of data.
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 3 - - H402: Harmful to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		It was classified into Category 3 from 48-hour EC50=85mg/L of Crustacea (Daphnia magna) (Agricultural Chemical Registration Data, 2004).
11 Hazardous to the aquatic environment （Long-term） Category 3 - - H412: Harmful to aquatic life with long lasting effects P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		Classified into Category 3, since acute toxicity was Category 3 and rapid degradability and bioaccumulation potential are unknown.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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