GHS Classification Result

Chemical Name:pyraclofos
CAS:89784-60-1

Result:
ID: 1188
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual (10 Feb, 2006)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Classification not possible - - - - Classification not possible due to lack of data, though the substance contains nitrogen atoms adjacent to each other as chemical groups with explosive properties present and has the oxygen balance calculated at -168.5, higher than -200 of the criteria.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Classification not possible - - - - No data available
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Classification not possible - - - - Classification not possible due to lack of data, though the substance contains nitrogen atoms adjacent to each other and P-O bonds as chemical groups with explosive or self-reactive properties present
9 Pyrophoric liquids Classification not possible - - - - No data available
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available
12 Substances and mixtures which, in contact with water, emit flammable gases Classification not possible - - - - No data available
13 Oxidizing liquids Classification not possible - - - - No data available
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Organic compounds containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - No data available

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 3 Danger H301: Toxic if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ...
SPECIES: Rat ENDPOINT: LD50 VALUE: 237 mg/kg REFERENCE SOURCE: Agricultural Chemical Registration Data
1 Acute toxicity (Dermal) Not classified - - - - It was set as the outside of Category based on rat LD50 >2000mg/kg and that (Agricultural Chemical Registration Data) death is not observed at less than 2000mg/kg.
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available
1 Acute toxicity (Inhalation: Dusts and mists) Category 4 Warning H332: Harmful if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
It was set as category 4 based on rat LC50 = 1.46mg/L (Agricultural Chemical Registration Data) of 4-hour exposure.
2 Skin corrosion/irritation Not classified - - - - It carried out the outside of Category based on the statement that an irritant effect was not admitted in the skin irritation test using rabbits (Agricultural Chemical Registration Data).
3 Serious eye damage/eye irritation Not classified - - - - Based on the description that irritative changes were not observed in the eye irritation tests using rabbit (Agricultural Chemical Registration Data), it was set as the out of the Category.
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Not classified - - - - By the skin sensitivity test using a guinea pig, it carried out the outside of Category based on the statement (Agricultural Chemical Registration Data) that sensitizing was not acknowledged.
5 Germ cell mutagenicity Not classified - - - - There are no result of human multi generation epidemiology, multi generation mutagenicity test, and germ cell in vivo mutagenicity test, and there is the description that it is negative in the somatic cell in vivo mutagenicity test (mouse small core test) (Agricultural Chemical Registration Data (un-submitting)). So it is classified as the out of the Category.
6 Carcinogenicity Not classified - - - - In the examination of rat and mouse, based on the description that generating of treatment-related increased tumor was not observed in each examination (Agricultural Chemical Registration Data), it was out of the Category.
7 Reproductive toxicity Not classified - - - - Based on the statement that the reproductive function, reproductive potential, and the mischief on a child's generating were not acknowledged in the two-generation reproductive examination using rats and the medication examination during the pregnancy using rats and rabbits (Agricultural Chemical Registration Data). So it was set as the outside of Category.
8 Specific target organ toxicity - Single exposure Category 1 (nervous system) Danger H370: Causes damage to organs (nervous system) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
It was considered as Category 1 (nerve systems) based on the descrption (Agricultural Chemical Registration Data ) that diminished spontaneous activity, gait abnormality, diarrhea, salivation, tremor, lacrimation, ocular proptosis, and breathing abnormality were observed in the oral administration examination using rats and mice and the inhalation examination using rats at the dose within the range of guidance value in Category 1 (oral: 137-231mg/kg, Inhalation: 0.51-0.66 mg/L).
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - In the feeding oral administration tests for three months using rats, mice and dogs, inhibition of plasma, hemocyte, and brain cholinesterase activity, and the decrease of erythrocyte numbers, hemoglobin concentration, and a hematocrit value was observed in exposure of the guidance value range (more than 0.55 mg/kg) of Category 1, although there is a statement that there was no associated symptom (Agricultural Chemical Registration Data ), but since there is no data in other given doses, it cannot classify.
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
It was classified into Category 1 from 48-hour EC50=0.0032mg/L of Crustacea (Daphnia magna) (Agricultural Chemical Registration Data, 1992).
11 Hazardous to the aquatic environment (Long-term) Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
Classified into Category 1, since acute toxicity was Category 1, supposed less bioaccumulative (log Kow=3.79 (Agricultural Chemical Registration Data)), though rapid degradability is unknown.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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