GHS Classification Result

Chemical Name:Sodium cyanate
CAS:917-61-3

Result:
ID: 1210
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual (10 Feb, 2006)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Not classified - - - - Non-combustible (BGIA, GESTIS-database on hazardous substancess, Accessed in June 2006)
8 Self-reactive substances and mixtures Not classified - - - - Although the grouping relevant to explosibility was not included and the grouping (unsaturated bonds) relevant to autoreactive was included. And it was used as pesticide, it was thought that there was no autoreactive and it was classified as outside of Category.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - Non-combustible (BGIA, GESTIS-database on hazardous substancess, Accessed in June 2006)
11 Self-heating substances and mixtures Not classified - - - - Non-combustible (BGIA, GESTIS-database on hazardous substances, accessed in June. 2006)
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified - - - - Stable to water (the water solubility is obtained)
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Classification not possible - - - - No data available
15 Organic peroxides Not applicable - - - - Inorganic compound
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ...
Based on the LD50 values in rats of 1500mg/kg (RTECS, 2006) and 1206.1mg/kg (preparation) (the Agrichemicals Newsletter Supplement No. 17, 1994), the lower value was adopted to classify the substance as Category 4.
1 Acute toxicity (Dermal) Classification not possible (Category 5 or Not classified) - Warning H313: May be harmful in contact with skin P312: Call a POISON CENTER or doctor/physician if you feel unwell. According to rat LD50 >2000mg/kg (the agricultural newsletter supplement No. 17, 1994)of a tablet, it cannot be classified (Category 5 or outside of Category).
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Solid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Not applicable - - - - The vapor pressure of this product is very low (it is less than 0.00001Pa at 20degC), and it was considered to be difficult to carry out vapor exposure. So it was outside of classification.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - Classification not possible due to lack of data
2 Skin corrosion/irritation Not classified - - - - In the primary skin irritation test in rabbits of the agricultural newsletter supplement No. (1994) 17, it disappeared in 24 hours although slight erythema was seen in all patients 1 hour afterward as a result of exposing 1.0g (0.5g as this product) of samples for 4 hours, it carried out the outside of Category.
3 Serious eye damage/eye irritation Category 2A Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
In rabbit eye primary irritation study of the agricultural newsletter supplement No.17 (1994), as a result of prescribing 0.1g of this product for the patient in conjunctival sacs, mild to moderate corneal opacity and conjunctival redness, etc. were seen. But symptoms resolved by 14 days in non-washing eyes group, and by 10 days in the washing eyes group. So it was set as Category 2A.
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Not classified - - - - Since it was negative in the skin sensitivity test (the Buehler method) of the guinea pig of the agricultural newsletter supplement No. (1994) 17, it carried out the outside of Category.
5 Germ cell mutagenicity Classification not possible - - - - Since it was negative in the small core test of the mouse of the agricultural newsletter supplement No. 17 (1994), and it is classified as the out of the Category. In addition, it was negative at the Ames test, and negative in chromosome aberration test in the in vitro mutagenicity test of the agricultural newsletter supplement No.17 (1994).
6 Carcinogenicity Classification not possible - - - - No data available
7 Reproductive toxicity Classification not possible - - - - Although teratogenic effects of this product was not acknowledged in the teratogenicity study of therabbit and rat (Agricultural newsletter supplement No. (1994) 17), the data of impact on reproductive potential is not found. And data is insufficient, it cannot classify.
8 Specific target organ toxicity - Single exposure Category 1 (central nervous system) Danger H370: Causes damage to organs (central nervous system) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
Since the seizure induction effect was observed at 100mg/kg of oral administration in the general pharmacology studies in the mouse of the agricultural newsletter supplement No. (1994) 17, it was considered as Category 1 (central nervous systems) by comparison with a guidance value.
9 Specific target organ toxicity - Repeated exposure Category 2 (nervous system) Warning H373: May cause damage to organs through prolonged or repeated exposure (nervous system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
There is a statement that the influence on an optic nerve (change of a visual field) was observed in human repeated exposure (RTECS (2006) of Priority 2 document). Moreover, although an exposure periods is less than (3-10 days) 14 days, there is a report that the influence on the peripheral nervous system and central nervous system (flaccid paralysis, and somnolence) was observed in the mouse and the guinea pig (RTECS, 2006). As mentioned above, it was classified into Category 2 (nervous systems).
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Classification not possible - - - - No data available
11 Hazardous to the aquatic environment (Long-term) Classification not possible - - - - No data available.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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