GHS Classification Result
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
Reference：
Chemical Name：Propanenitrile, 2-methyl-
CAS：78-82-0
Result：
| ID: | 1213 |
| Classifier: | Inter-ministerial Committee on GHS |
| Year Classified: | FY2006 |
| Reference Manual: | GHS Classification Manual （10 Feb, 2006） |
PHYSICAL HAZARDS
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable | - | - | - | - | There are no chemical groups associated with explosive properties present in the molecules. |
| 2 | Flammable gases （including chemically unstable gases） | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products |
| 4 | Oxidizing gases | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 5 | Gases under pressure | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 6 | Flammable liquids | Category 2 |
|
Danger | H225: Highly flammable liquid and vapour |
P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. P370+P378: In case of fire: Use ... for extinction. P403+P235: Store in a well-ventilated place. Keep cool. P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking. P233: Keep container tightly closed. P240: Ground/bond container and receiving equipment. P241: Use explosion-proof electrical/ventilating/lighting/.../equipment. P242: Use only non-sparking tools. P243: Take precautionary measures against static discharge. P280: Wear protective gloves/protective clothing/eye protection/face protection. P501: Dispose of contents/container to ... |
Category 2 because of UNRTDG No. 2284 Class: 3(6.1), PGII and its flash point: 8degC and initial boiling point (boiling point): 107degC (Sax, 11th, 2004). |
| 7 | Flammable solids | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 8 | Self-reactive substances and mixtures | Not applicable | - | - | - | - | There are no chemical groups associated with explosive or self-reactive properties present in the molecule. |
| 9 | Pyrophoric liquids | Not classified | - | - | - | - | Even if it contacts the normal temperature air, it does not ignite spontaneously (ignition points is 482 degC (NFPA, 13th, 2003)). |
| 10 | Pyrophoric solids | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 11 | Self-heating substances and mixtures | Not classified | - | - | - | - | CHRIS-Chemical Hazard Response Information System (U. S.DOT/U.S.Coast Guard, 1999) has the description "it is stable during transportation", and it carried out the outside of Category. |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | - | The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
| 13 | Oxidizing liquids | Not applicable | - | - | - | - | Organic compounds containing no oxygen, fluorine and chlorine. |
| 14 | Oxidizing solids | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 15 | Organic peroxides | Not applicable | - | - | - | - | Organic compounds containing no -0-0- structure |
| 16 | Corrosive to metals | Classification not possible | - | - | - | - | No data available |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Category 3 |
|
Danger | H301: Toxic if swallowed |
P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P330: Rinse mouth. P405: Store locked up. P501: Dispose of contents/container to ... |
Based on the LD50 value of 50-100mg/kg in rats (PATTY (5th, 2001)), the substance was classified as Category 3. There are also mentions of LD50= 50mg/kg (RTECS(1997)) and 100mg/kg (HSDB(2003)). |
| 1 | Acute toxicity （Dermal） | Category 2 |
|
Danger | H310: Fatal in contact with skin |
P302+P350: IF ON SKIN: Gently wash with plenty of soap and water. P262: Do not get in eyes, on skin, or on clothing. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P280: Wear protective gloves/protective clothing/eye protection/face protection. P310: Immediately call a POISON CENTER or doctor/physician. P322: Specific treatment （see ... on this label）. P361: Remove/Take off immediately all contaminated clothing. P363: Wash contaminated clothing before reuse. P405: Store locked up. P501: Dispose of contents/container to ... |
Rabbit dermal LD50 = 200mg/kg (RTECS (1997)) and 310 mg/kg (HSDB (2003)). The higher toxic value (LD50 = 200mg/kg) was adopted, and it was set as Category 2. |
| 1 | Acute toxicity （Inhalation: Gases） | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 1 | Acute toxicity （Inhalation: Vapours） | Category 3 |
|
Danger | H331: Toxic if inhaled |
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P311: Call a POISON CENTER or doctor/physician. P321: Specific treatment （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ... |
There are descriptions that all rat died with about 1 hour inhalation administration of vapor with 5500ppm (5500ppm/1H = >3.9mg/L/4H: Category 3 range) (PATTY (5th, 2001)) and that lowest lethal concentration of rat inhalation exposure is 1000ppm/4H (it is 2.8mg/L/4H as steam equivalent: Category 3 range). It was not LC50 value, but it was guessed that an acute toxicities estimates in the range of Category 3, it was classified as Category 3. |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Classification not possible | - | - | - | - | No data available |
| 2 | Skin corrosion/irritation | Category 3 | - | Warning | H316: Causes mild skin irritation | P332+P313: If skin irritation occurs: Get medical advice/attention. | Since there was description that there is slight (Mild) irritation is indicated by Draize's method which carried out open application to the rabbit (RTECS (1997)), and the description that humans skin is stimulated (HSDB (2003), HSFS (2000)), it was set as category 3. |
| 3 | Serious eye damage/eye irritation | Category 2A-2B |
|
Warning | H319: Causes serious eye irritation |
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313: If eye irritation persists: Get medical advice/attention. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection. |
There is the description that "blister and watering eye, reddens eyelid and reddens conjunctiva" are caused to eyes of rabbit (RTECS (1997)), and there is stimulant also to human eyes (HSDB (2003), HSFS and (2000)). So it is set as Category 2A-2B. In addition, the detailed categorization from this data is difficult. |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | - | No data available |
| 4 | Skin sensitization | Classification not possible | - | - | - | - | No data available |
| 5 | Germ cell mutagenicity | Classification not possible | - | - | - | - | No data available |
| 6 | Carcinogenicity | Classification not possible | - | - | - | - | No data available |
| 7 | Reproductive toxicity | Classification not possible | - | - | - | - | Although there is description that the fetal death/fetal toxicity in concentration with clear maternal toxicity were seen in rat inhalation developmental toxicity studies. (PATTY (5th, 2001). However, according to PATTY, there was no maternal toxicity while the original text says that there was maternal toxicity.) Since there is no other data, and data is insufficient, it cannot be classified. |
| 8 | Specific target organ toxicity - Single exposure | Category 2 (liver), Category 3 (respiratory tract irritation) |
|
Warning |
H371: May cause damage to organs (liver) H335: May cause respiratory irritation (respiratory tract irritation) |
P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P405: Store locked up. P501: Dispose of contents/container to ... P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P312: Call a POISON CENTER or doctor/physician if you feel unwell. |
When the amount which corresponds to Category 1 in a guidance value is administered orally to a rat, the description that it has impact on liver were seen (HSDB (2003)) but it is data of Priority 2 document and was considered as Category 2 (liver) according to the technical indicator since it does not suit the acceptance criteria for classifying into Category 1. Moreover, since the throat was stimulated by inhalation to humans (HSDB (2003), HSFS (2000)), it was considered as Category 3 (respiratory irritant). In addition, description that the this product affects the human heart in the document of Priority 2 were seen (SITTIG (4th, 2001)), but the data which is supported was not found. |
| 9 | Specific target organ toxicity - Repeated exposure | Classification not possible | - | - | - | - | Insufficient data available |
| 10 | Aspiration hazard | Classification not possible | - | - | - | - | No data available |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Classification not possible | - | - | - | - | No data available |
| 11 | Hazardous to the aquatic environment （Long-term） | Classification not possible | - | - | - | - | No data available. |
NOTE:
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* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference：
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Reference Manual |
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Definitions / Abbreviations |
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Model Label by MHLW |
MHLW Website （in Japanese Only） |
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Model SDS by MHLW |
MHLW Website （in Japanese Only） |