GHS Classification Result

Chemical Name：Esfenvalerate
CAS：66230-04-4

Result：
ID: 1218
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Classification not possible - - - - Classification not possible due to lack of experimental data, though "Flammable"(ICSC(J), 2004)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - Non-pyrophoric when in contact with air at a room temperature and used as agricultural chemicals.
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to solid (melting point <= 140degC) substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not applicable - - - - Organic compounds containing oxygen and chlorine and these elements are chemically bonded only to carbon (but not to other elements).
15 Organic peroxides Not applicable - - - - Organic compounds containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 3 Danger H301: Toxic if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the oral LD50 value of 90mg/kg in rats (JMPR (2002)), the substance was classified as Category 3. [Note] Also refer to fenvalerate (alpha-cyano-3-phenoxybenzyl = -2-(4-chlorophenyl)-3-methylbutyrate) (ID 269, Chemical Abstracts Service: 51630-58-1), which is the optical isomer of this substance.
1 Acute toxicity （Dermal） Classification not possible (Category 5 or Not classified) - Warning H313: May be harmful in contact with skin P312: Call a POISON CENTER or doctor/physician if you feel unwell. There is a report of rabbit dermal LD50 >2g/kg (JMPR (2002), HSDB (2003), RTECS (2004)) and rat dermal LD50 >5g/kg (JMPR (2002), RTECS (2004)). But Category cannot be specified, it cannot be classified (Category 5 or outside of Category).
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Solid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Dusts and mists） Category 2 Danger H330: Fatal if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P284: Wear respiratory protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P320: Specific treatment is urgent （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		It was set as Category 2 based on inhalation by mists in a rat LC50 (4hr) = 0.48mg/L (JMPR (2002)).
2 Skin corrosion/irritation Category 3 - Warning H316: Causes mild skin irritation P332+P313: If skin irritation occurs: Get medical advice/attention. Since there is description that human skin is stimulated slightly (ICSC (J), (2004)), and irritation was slightly indicated in the test using a rabbit (JMPR (2002)), it was set as Category 3. In addition, also refer to a fenvalerate (ID 269, Chemical Abstracts Service:51630-58-1).
3 Serious eye damage/eye irritation Category 2B - Warning H320: Causes eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling. 		There is description that the human eye is stimulated mildly (ICSC (J) (2004)), and mild stimulation for the eyes was admitted in the test using a rabbit (JMPR (2002)). So it was set as Category 2B. In addition, refer to a fenvalerate (ID269, CAS: 51630-58-1).
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ... 		By repetition or long-term contact to human, there is description (ICSC(J)(2004)) that skin sensitization may be caused, although individual reaction is slight, high sensitization rate is seen (JMPR (2002)) in the maximization test using a guinea pig, it was set to Category 1. In addition, negativity is reported by a guinea pig Buhler examination and another skin sensitization study (test unknown) (JMPR (2002)). Moreover, in the fenvalerate (CAS: ID269, 51630-58-1), skin sensitization is considered as Category 1.
5 Germ cell mutagenicity Not classified - - - - There is negative result in in vivo small core test using mouse bone marrow cells, and in in vitro mutagenicity test (the gene mutation test and chromosome aberration test using a cultured cell) (all being JMPR(s) (2002)). So it is classified as the out of the Category. In addition, the fenvalerate (ID 269, Chemical Abstracts Service:51630-58-1) is considered as the outside of Category.
6 Carcinogenicity Classification not possible - - - - Although it is considered as oncogenic by administration test of rat for two years (RTECS (2004)), data is insufficient and it cannot be classified. In addition, the fenvalerate (ID 269, Chemical Abstracts Service:51630-58-1) is carried out the outside of Category.
7 Reproductive toxicity Not classified - - - - In the two-generation reproduction toxicity studies using a rat, and the teratogenicity study using rats and rabbits, the clear reproductive and developmental toxicity in child animals was not acknowledged (all are JMPR (2002)), so it was set as the outside of Category. In addition, the fenvalerate (ID 269, CAS: 51630-58-1) is set as the outside of Category.
8 Specific target organ toxicity - Single exposure Category 1 (nervous system), Category 3 (respiratory tract irritation) Danger
Warning 		H370: Causes damage to organs (nervous system)
H335: May cause respiratory irritation (respiratory tract irritation) 		P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ...
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell. 		It was considered as Category 1(nerve systems) and Category 3 (respiratory irritant) based on the description that in a rat, at the dose which is equivalent to Category 1 in a guidance value the effect on unusual spasms, muscle fibrillation, ataxie, tremor and limb palsy, and nervous systems are observed (JMPR (2002)), and it affects the human nervous system, and stimulates mildly the airway (ICSC (2004)). In addition, also refer to a fenvalerate (ID 269, Chemical Abstracts Service: 51630-58-1).
9 Specific target organ toxicity - Repeated exposure Category 2 (nervous system) Warning H373: May cause damage to organs through prolonged or repeated exposure (nervous system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		Since there was description that the influence on nervous systems, such as salivation, tremor, vomiting, and twitching of extremities were observed in rats or mouse, with the dose which is equivalent to Category 2 with a guidance value(JMPR(2002)), it was classified into Category 2 (nervous systems). In addition, refer to a fenvalerate (ID269, CAS: 51630-58-1).
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		It was classified into Category 1 from 96-hour LC50=0.07ppb of fishes (Rainbow trout) (AQUIRE, 2003).
11 Hazardous to the aquatic environment （Long-term） Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Classified into Category 1, since acute toxicity is Category 1, supposed not rapidly degrading (BIOWIN), and bioaccumulative (log Kow=6.22 (PHYSPROP Database, 2005)).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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