GHS Classification Result
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
Reference：
Chemical Name：Benzonitrile
CAS：100-47-0
Result：
| ID: | 1221 |
| Classifier: | Inter-ministerial Committee on GHS |
| Year Classified: | FY2006 |
| Reference Manual: | GHS Classification Manual （10 Feb, 2006） |
PHYSICAL HAZARDS
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable | - | - | - | - | There are no chemical groups associated with explosive properties present in the molecules. |
| 2 | Flammable gases （including chemically unstable gases） | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products |
| 4 | Oxidizing gases | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 5 | Gases under pressure | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 6 | Flammable liquids | Category 4 | - | Warning | H227: Combustible liquid |
P370+P378: In case of fire: Use ... for extinction. P403+P235: Store in a well-ventilated place. Keep cool. P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking. P280: Wear protective gloves/protective clothing/eye protection/face protection. P501: Dispose of contents/container to ... |
Flash point: 75degC(C.C.) (ICSC(J), 1999). |
| 7 | Flammable solids | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 8 | Self-reactive substances and mixtures | Not applicable | - | - | - | - | There are no chemical groups associated with explosive or self-reactive properties present in the molecule. |
| 9 | Pyrophoric liquids | Not classified | - | - | - | - | The ignition points is 550 degC (ICSC (J), 1999), and even if it contacts the air of normal temperature, it does not ignite spontaneously. |
| 10 | Pyrophoric solids | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 11 | Self-heating substances and mixtures | Not classified | - | - | - | - | The intended use is as solvent, and it is considered that there is no self-febrility, and was set to the outside of category. |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | - | The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
| 13 | Oxidizing liquids | Not applicable | - | - | - | - | Organic compounds containing no oxygen, fluorine and chlorine. |
| 14 | Oxidizing solids | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 15 | Organic peroxides | Not applicable | - | - | - | - | Organic compounds containing no -0-0- structure |
| 16 | Corrosive to metals | Classification not possible | - | - | - | - | No data available |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Category 4 |
|
Warning | H302: Harmful if swallowed |
P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P330: Rinse mouth. P501: Dispose of contents/container to ... |
Based on the value of LD50 = 848mg/kg calculated by the rat oral LD50 values : 1500, 720, 1000, 800 and 840mg/kg (IUCLID (2000)) and 700, 1500 and 1300mg/kg (HSDB(2003)), the substance was classified as Category 4. |
| 1 | Acute toxicity （Dermal） | Category 4 |
|
Warning | H312: Harmful in contact with skin |
P302+P352: IF ON SKIN: Wash with plenty of soap and water. P280: Wear protective gloves/protective clothing/eye protection/face protection. P312: Call a POISON CENTER or doctor/physician if you feel unwell. P322: Specific treatment （see ... on this label）. P363: Wash contaminated clothing before reuse. P501: Dispose of contents/container to ... |
Rat dermal LD50 = 1200mg/kg (IUCLID (2000), RTECS (2000), HSDB (2003)). Rabbit dermal LD50 = 1250mg/kg (IUCLID (2000), RTECS (2000), HSDB (2003)). The lower one (LD50=1200 mg/kg) was adopted, and it was set as Category 4. |
| 1 | Acute toxicity （Inhalation: Gases） | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 1 | Acute toxicity （Inhalation: Vapours） | Category 3 |
|
Danger | H331: Toxic if inhaled |
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P311: Call a POISON CENTER or doctor/physician. P321: Specific treatment （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ... |
Based on LC50 = 1900ppm (equivalent 8mg/L) which is obtained by having converted rat inhalation LC50 value (8hr, 950ppm) for 4 hours, it was classified as Category 3. In addition, the saturated concentration of this product is 1000ppm, and it is presumed that the inhalation test is done in the state of steam. |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Classification not possible | - | - | - | - | No data available |
| 2 | Skin corrosion/irritation | Category 2 |
|
Warning | H315: Causes skin irritation |
P302+P352: IF ON SKIN: Wash with plenty of soap and water. P332+P313: If skin irritation occurs: Get medical advice/attention. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection. P321: Specific treatment （see ... on this label）. P362: Take off contaminated clothing and wash before reuse. |
Since there was description that it stimulates to "Moderate (moderately)" as a result of the standard Draize's method for a rabbit (RTECS and (2000), HSDB (2003)) and the human skin is stimulated (ICSC (J), (1999), SITTIG (4th, 2002), HSFS (2000)), it was set as category 2. |
| 3 | Serious eye damage/eye irritation | Category 2A-2B |
|
Warning | H319: Causes serious eye irritation |
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313: If eye irritation persists: Get medical advice/attention. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection. |
Since stimulus condition like the redness of a conjunctiva and conjunctiva dropsy is acknowledged as a result of the injections against eyes of rabbit (IUCLID (2000)), and there is the description that a human ocular is stimulated (ICSC (J), (1999), SITTIG (4th, 2002), and HSFS (2000)), it is set as Category 2A-2B. In addition, the detailed categorization from the acquired information is difficult. |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | - | No data available |
| 4 | Skin sensitization | Classification not possible | - | - | - | - | Although there is a report that there was no causing sensitivity (HSDB(2003)) as a result of doing a patch test to a volunteer, there is no other data, and data is insufficient and it cannot classify. |
| 5 | Germ cell mutagenicity | Classification not possible | - | - | - | - | There is only the result of the Ames test negative in in vitro (IUCLID (2000)), and it cannot be classified because of insufficient data |
| 6 | Carcinogenicity | Classification not possible | - | - | - | - | No data available |
| 7 | Reproductive toxicity | Classification not possible | - | - | - | - | No data available |
| 8 | Specific target organ toxicity - Single exposure | Category 2 (central nervous system), Category 3 (respiratory tract irritation) |
|
Warning |
H371: May cause damage to organs (central nervous system) H335: May cause respiratory irritation (respiratory tract irritation) |
P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P405: Store locked up. P501: Dispose of contents/container to ... P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P312: Call a POISON CENTER or doctor/physician if you feel unwell. |
Since there is description that it has influence of distraction, headache, nausea, vomiting, etc., in the document of Priority 2 as a result of human exposures (ICSC (J) (1999), SITTIG (4th, 2002), HSFS (2000)), and the symptom (a coma, limbs spasm, etc.) which derives in control of central nervous system by dose to rats and mice (dose course, amount of dose are unknown) was observed (HSDB (2003)), it was considered as Category 2 (central nervous system). Furthermore, since the respiratory tracts was stimulated (ICSC (J) (1999), HSFS (2000)), it was considered as Category 3 (respiratory irritation). |
| 9 | Specific target organ toxicity - Repeated exposure | Category 2 (central nervous system, liver) |
|
Warning | H373: May cause damage to organs through prolonged or repeated exposure (central nervous system, liver) |
P260: Do not breathe dust/fume/gas/mist/vapours/spray. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ... |
Since there is description that disorder is occured on central nervous system and liver in the inhalation exposure experiment (steam) in a rat, exposure of the dosage which is equivalent to Category 2 with a guidance value (IUCLID(2000), and RTECS(2000)), it was classified into Category 2 (central nervous system, and liver). |
| 10 | Aspiration hazard | Classification not possible | - | - | - | - | No data available |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Category 3 | - | - | H402: Harmful to aquatic life |
P273: Avoid release to the environment. P501: Dispose of contents/container to ... |
It was classified into Category 3 from 24-hour EC50=30930microg/L(AQUIRE, 2003) of Crustacea (Water fleas). |
| 11 | Hazardous to the aquatic environment （Long-term） | Not classified | - | - | - | - | Since rapidly degrading (BOD: 63.4% (existing chemical safety inspections data)), and less bio-accumulative (log Kow=1.56 (PHYSPROP Database, 2005)). |
NOTE:
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* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference：
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Reference Manual |
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Definitions / Abbreviations |
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Model Label by MHLW |
MHLW Website （in Japanese Only） |
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Model SDS by MHLW |
MHLW Website （in Japanese Only） |