GHS Classification Result

Chemical Name:dinocap
CAS:39300-45-3

Result:
ID: 1241
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual (10 Feb, 2006)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not classified - - - - Not classified because of no appropriate data on an explosibility, though the substance contains N-O bonds as chemical groups with explosive properties present and has the oxygen balance calculated at -184.4, higher than -200 of the criteria.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Category 4 - Warning H227: Combustible liquid P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ...
Category 4 because of its flash point: 67degC (PM, 13th, 2003, Pensky-Martens closed cup)
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not classified - - - - Although the grouping relevant to explosive (N-O) was included, the grouping relevant to autoreactive was not included and the data in which autoreactive is indicated was not found, either. So it was considered outside of Category.
9 Pyrophoric liquids Not classified - - - - Uses are agricultural chemicals, and even if it contacts the normal temperature air, it does not ignite spontaneously.
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Classification not possible - - - - No data available
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Organic compounds containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - No data available

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ...
Based on the value of LD50 = 834mg/kg calculated from the rat oral LD50 values : 980 (RTECS (2003), HSDB (2003)), 766 (RTECS (2003)) and 950mg/kg (HSDB (2003)), the substance was classified as Category 4.
1 Acute toxicity (Dermal) Not classified - - - - Considering rabbit dermal LD50 = 9400mg/kg (RTECS (2003)), it was set as the outside of Category.
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available
1 Acute toxicity (Inhalation: Dusts and mists) Category 2 Danger H330: Fatal if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P284: Wear respiratory protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P320: Specific treatment is urgent (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
It was set as category 2 based on rat LC50 (4h) = 0.36mg/L (RTECS (2003)). In addition, it is presumed that the saturated concentration of this product is very low, and the inhalation test is done in mist conditions.
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment (see ... on this label).
P362: Take off contaminated clothing and wash before reuse.
Since there is the description that human skin is stimulated (ICSC (J), (1997), HSDB (2003)), it was set as category 2.
3 Serious eye damage/eye irritation Classification not possible - - - - No data available
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment (see ... on this label).
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ...
By repetition or the long-term contact to the human skin, since there is a report of a patch test positivity (HSDB(2003)) in addition to there is a description that sensitization of the skin may be carried out (ICSC(J)(1997)), it was referred to as Category 1.
5 Germ cell mutagenicity Classification not possible - - - - Although there is the positive report in Ames test reporting (RTECS (2003)), other test results containing in vivo cannot be found. So it cannot be classified because of insufficient data
6 Carcinogenicity Classification not possible - - - - There is the report which suggests carcinogenic in a mouse (RTECS (2003)) and reports denies was seen (HSDB (2003)). But data is insufficient and it cannot taxonomic.
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
Since teratogenicity (cleft palate, torticollis, etc) was seen in fetal animals (Catalog of teratogenic agents (2004), RTECS (2003), HSDB (2003)) in the test on mice and hamsters, a possibility of causing malformation to humans was suggested in the animal studies (ICSC (J), (1997)). So it was set as Category 2.
8 Specific target organ toxicity - Single exposure Classification not possible - - - - Insufficient data available.
9 Specific target organ toxicity - Repeated exposure Category 2 (liver) Warning H373: May cause damage to organs through prolonged or repeated exposure (liver) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
Since there is a report that effect was observed in the liver function as a result of occupational exposure of this product (HSDB (2003) the document of Priority 2), and , that the hepatocyte necrosis was observed in the rat with given dose of the range of Category 2 in a guidance value (RTECS (2003) the document of Priority 2), it was classified into Category 2 (liver).
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
It was classified into Category 1 from 48-hour EC50=4.2ppb of Crustacea (Daphnia magna) (AQUIRE, 2003).
11 Hazardous to the aquatic environment (Long-term) Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
Classified into Category 1, since acute toxicity is Category 1, supposed not rapidly degrading (BIOWIN), and bioaccumulative (log Kow=5.98 (PHYSPROP Database, 2005)).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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