GHS Classification Result

Chemical Name:propaphos
CAS:7292-16-2

Result:
ID: 1242
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual (10 Feb, 2006)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Category 4 - Warning H227: Combustible liquid P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ...
Since the flash point was 76 degC (testing method unknown), it was classified as Category 4 (GHS standards: flash point being more than 60 degC and 93 degC or less).
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Classification not possible - - - - Classification not possible due to lack of data, though the substance contains N-O bonds as chemical groups with explosive or self-reactive properties present
9 Pyrophoric liquids Not classified - - - - Since the flash points is 76 degC, ignition temperature is judged to be 70 degC or more.
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified - - - - Since tests for such as water solubility and water soundness were performed (Agricultural Chemical Registration Data), it can be judged that it is stable in the water.
13 Oxidizing liquids Classification not possible - - - - No data available
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Organic compounds containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - No data available

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 3 Danger H301: Toxic if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ...
Based on the rat LD50 values : 79.8mg/kg (male) and 72.5mg/kg (female) (Agricultural Chemical Registration Data), we adopted the lower value (LD50=72.5mg/kg) to classify the substance as Category 3.
1 Acute toxicity (Dermal) Category 2 Danger H310: Fatal in contact with skin P302+P350: IF ON SKIN: Gently wash with plenty of soap and water.
P262: Do not get in eyes, on skin, or on clothing.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P322: Specific treatment (see ... on this label).
P361: Remove/Take off immediately all contaminated clothing.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ...
It was set as Category 2, based on LD50 = 72.0mg/kg ( the lower value among rat male LD50 = 88.5mg/kg and female LD50 = 72.0mg/kg (Agricultural Chemical Registration Data)).
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available
1 Acute toxicity (Inhalation: Dusts and mists) Category 1 Danger H330: Fatal if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P284: Wear respiratory protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P320: Specific treatment is urgent (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
It was set as Category 1 based on LC50 = 0.039mg/L on the both sex rat (Agricultural Chemical Registration Data).
2 Skin corrosion/irritation Classification not possible - - - - Since there was no data about an agricultural-chemicals field object, it was presupposed that it cannot classify.
3 Serious eye damage/eye irritation Classification not possible - - - - Since there was no data about a pesticide ingredients, it was presupposed that it cannot classify.
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Not classified - - - - By the skin sensitization study by the Maximization method in a guinea pig, based on a statement (Agricultural Chemical Registration Data) that a skin reaction was not accepted, it carried out the outside of Category.
5 Germ cell mutagenicity Classification not possible - - - - Although there is the description that it was negative in the chromosome aberration inducement test in the Chinese hamster cultured cell of in vitro and the reverse mutation test using the bacteria (Agricultural Chemical Registration Data), there is no result of human multi generation epidemiology, multi generation mutagenicity test, and germ cell in vivo mutagenicity test, the somatic cell in vivo mutagenicity test of in vitro. And there is no in vivo genotoxicity test of germ cell and somatic cell and there is no result of the multi index positive finding in in vitro mutagenicity test. So it cannot be classified
6 Carcinogenicity Not classified - - - - It carried out the outside of Category based on the statement (Agricultural Chemical Registration Data) that frequency of these neoplastic increase in the incidence and be earlier relevant to administration were not acknowledged in the carcinogenicity test of rats and mice.
7 Reproductive toxicity Not classified - - - - Based on the statement that although the general toxicity against parent animals was acknowledged in the three-generation reproduction study on rats and the reproductive toxicity examination on rats and rabbits, the effect on teratogenicity and reproductive potential was not acknowledged (Agricultural Chemical Registration Data). So it was set as the outside of Category.
8 Specific target organ toxicity - Single exposure Category 1 (systemic toxicity, nervous system, lung, liver) Danger H370: Causes damage to organs (systemic toxicity, nervous system, lung, liver) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
It was considered as Category 1 (systemicity, a nervous systems, lungs, liver) based on the description (Agricultural Chemical Registration Data ) that diminished spontaneous activity, tremor, salivation, dacryorrhea, blunting of outsaide responce, weakness like symptom, hematological adhesions of nasal periphery, bloody tears, the dirt of the abdomen, and downward recumbent position, the dirt of eyelids periphery, ataxia, respiration disorder, congestion or swelling of liver, distinguished blister formation in apicalus of pulmonary Clara cell at the dose within the range of guidance value in Category 1 (oral administration: 72.0-88.5mg/kg, inhalation (mist): 39.2 below mg/m3 ).
9 Specific target organ toxicity - Repeated exposure Category 1 (nervous system, liver) Danger H372: Cause damage to organs through prolonged or repeated exposure (nervous system, liver) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
Based on description that the decrease of serum cholinesterase activity and liver parenchymal cells diffuse fatty change degenerations were observed in the repeated administration study to a rat and a mouse with the given dose (0.5-10 mg/kg or less) of guidance value within the limits of Category 1 (Agricultural Chemical Registration Data), it was classified into Category 1 (nervous system, and liver).
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 2 - - H401: Toxic to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ...
It was classified into Category 2 from 96-hour LC50=5.2mg/L of fishes (Rainbow trout) (Agricultural Chemical Registration Data, 1983).
11 Hazardous to the aquatic environment (Long-term) Category 2 - H411: Toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
Classified into Category 2, since acute toxicity was Category 2 and supposed not rapidly degrading (BIOWIN), though supposed less bio-accumulative (log Kow=3.67(PHYSPROP Database, 2005)).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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