GHS Classification Result

Chemical Name：pirimicarb
CAS：23103-98-2

Result：
ID: 1244
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Classification not possible - - - - No data available
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - Non-pyrophoric when in contact with air at a room temperature and used as agricultural chemicals.
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to solid (melting point <= 140degC) substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not applicable - - - - Organic compounds containing oxygen and the oxygen is chemically bonded only to carbon (but not to other elements).
15 Organic peroxides Not applicable - - - - Organic compounds containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 3 Danger H301: Toxic if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Because the rat oral LD50s: 68, 147-210, 101-147 and 165-221mg/kg (JMPR375 (1976)) are all within the range of Category 3, the substance was classified as Category 3.
1 Acute toxicity （Dermal） Category 3 Danger H311: Toxic in contact with skin P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P322: Specific treatment （see ... on this label）.
P361: Remove/Take off immediately all contaminated clothing.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Dermal LD50 = 500mg/kg in rats and rabbits (both. RTECS (2003)), it was set as Category 3.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Solid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Dusts and mists） Category 2 Danger H330: Fatal if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P284: Wear respiratory protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P320: Specific treatment is urgent （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the value (0.5mg/L) converted from oral LC50 (6h) = 0.3mg/L (JMPR375 (1976), HSDB (2003)) in a rat into exposure for 4 hours, it was set as category 2. In addition, the saturated concentration of this product is about 4*10^(-5)mg/L (4*10^(-3)ppm), it is presumed that the experiment was conducted in the state of the particulate.
2 Skin corrosion/irritation Not classified - - - - Since irritation was not acknowledged when the this product (5%, 25%, 50% of content) was applied to skin of rabbits (JMPR375 (1976)), it carried out the outside of Category.
3 Serious eye damage/eye irritation Category 2B - Warning H320: Causes eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling. 		Since, as for this material formulations (contents is 5%, 25%, 50%), "Mild"irritation was acknowledged for the eyes of the rabbit (JMPR375(1976)), it was set as Category 2B.
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Not classified - - - - In the test (test unknown) using a guinea pig, since there is a description that the sensitization response was not induced (JMPR375(1976), HSDB(2003)), it was taken as the outside of Category.
5 Germ cell mutagenicity Not classified - - - - There is the negative result in the dominant fatality test using mouse (JMPR599 (1982)), and the in vivo small core test using rat bone marrow cells (JMPR375 (1976)). So it is classified as the out of the Category. In addition, by Ames test, it is considered as negative, and by in vitro chromosome aberration test, it is considered as positive (JMPR560 (1981)).
6 Carcinogenicity Classification not possible - - - - The increase of the rate of incidence of a lung tumor (JMPR375 (1976)) or lymph sarcoma (JMPR599 (1982)) were seen in mouse. But it was negative in rats, and the information which will conclude if this substance is carcinogenic was not acquired. Therefore, it was presupposed that data is insufficient and it cannot be classified.
7 Reproductive toxicity Not classified - - - - In the reproduction and development tests using rats, mice or rabbit, since the teratogenicity and impact on reproductive potential was not acknowledged (JMPR375 (1976), HSDB (2003)), it was set as the outside of Category.
8 Specific target organ toxicity - Single exposure Category 2 (nervous system) Warning H371: May cause damage to organs (nervous system) P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P405: Store locked up.
P501: Dispose of contents/container to ... 		It is known that this product is carbamate pesticides and inhibit cholinesterase activity. Since reduction in cholinesterase activities in humans and rats (JMPR375 (1976), HSDB (2003)) and cholinergic symptoms in human (HSDB (2003)) were observed, it was considered as Category 2 (nervous systems).
9 Specific target organ toxicity - Repeated exposure Category 2 (nervous system, blood system) Warning H373: May cause damage to organs through prolonged or repeated exposure (nervous system, blood system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		Since vomiting, salivation, and anemia (decrease of hemoglobin, blood cell volume and erythrocytes etc.) were observed in the repeated administration with the dose level being equivalent to Category 2 with a guidance value to a dog (JMPR375 (1976), JMPR449 (1978), and HSDB (2003)), it was classified into Category 2 (nervous systems, and blood systems).
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		It was classified into Category 1 from 48-hour EC50=0.016mg/L of Crustacea (Daphnia magna) (ECETOC TR91, 2003).
11 Hazardous to the aquatic environment （Long-term） Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Classified into Category 1, since acute toxicity was Category 1, supposed not rapidly degrading (BIOWIN), though supposed less bioaccumulative (log Kow=1.7 (PHYSPROP Database, 2005)).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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