Chemical Name：ethyl N-[2,3-dihydro-2,2-dimethylbenzofuran-7-yloxycarbonyl(methyl)aminothio]-N-isopropyl-beta-alaninate
CAS：82560-54-1

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Acute toxicity （Oral）	Category 3		Danger	H301: Toxic if swallowed	P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P330: Rinse mouth. P405: Store locked up. P501: Dispose of contents/container to ...	We compared the rat LD50s in male (110mg/kg) and female (105mg/kg)in the oral administration test (Agricultural Chemical Registration Data). Based on the lower of these two values, the substance was classified as Category 3.
1	Acute toxicity （Dermal）	Not classified	-	-	-	-	It was set as the outside of Category. Based on rat LD50 >2000mg/kg in the dermal toxicity tests, and the description that there is no death (Agricultural Chemical Registration Data).
1	Acute toxicity （Inhalation: Gases）	Not applicable	-	-	-	-	Liquid (GHS definition)
1	Acute toxicity （Inhalation: Vapours）	Classification not possible	-	-	-	-	No data available
1	Acute toxicity （Inhalation: Dusts and mists）	Category 2		Danger	H330: Fatal if inhaled	P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P284: Wear respiratory protection. P310: Immediately call a POISON CENTER or doctor/physician. P320: Specific treatment is urgent （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ...	It was set as Category 2 based on rat LC50 = 0.15mg/L (Agricultural Chemical Registration Data) in the inhalation exposure test (dust and mists).
2	Skin corrosion/irritation	Not classified	-	-	-	-	In the skin irritation test of rabbits, it carried out the outside of Category based on the statement that skin irritation is not admitted (Agricultural Chemical Registration Data).
3	Serious eye damage/eye irritation	Category 2B	-	Warning	H320: Causes eye irritation	P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313: If eye irritation persists: Get medical advice/attention. P264: Wash ... thoroughly after handling.	In the eye irritation tests using a rabbit, mild redness of a conjunctiva and mild to moderate swelling were observed. And it disappeared within 24 to 48 hours after applying eyedrop (Agricultural Chemical Registration Data). So it was set as Category 2B.
4	Respiratory sensitization	Classification not possible	-	-	-	-	No data available
4	Skin sensitization	Not classified	-	-	-	-	In the skin sensitization test by guinea pig, it carried out the outside of Category based on the statement (Agricultural Chemical Registration Data) that sensitizing was not admitted.
5	Germ cell mutagenicity	Not classified	-	-	-	-	There is no result of human multi generation epidemiology, multi generation mutagenicity test, and germ cell in vivo mutagenicity test. And there is the description that it is negative result in all of the somatic cell in vivo mutagenicity test (chromosome aberration test using rat bone marrow cells and the small core test using mouse PCE stem cell) (Agricultural Chemical Registration Data). So it is classified as the out of the Category.
6	Carcinogenicity	Not classified	-	-	-	-	In the carcinogenicity tests using a mouse, it carried out the outside of Category based on the statement (Agricultural Chemical Registration Data) that tumor production and increased by medication were not seen.
7	Reproductive toxicity	Not classified	-	-	-	-	Based on the statement that although the toxicity by secondary effect was seen to the fetal animals in the two-generation reproduction test and teratogenicity test using a rat in the dose as which the general toxicity on parental animals was seen, the mischief on parental animals' sexual function or reproductive potential was not seen, and the mischief on generating of the fetal animals and teratogenicity were not acknowledged (Agricultural Chemical Registration Data). So it was set as the outside of Category.
8	Specific target organ toxicity - Single exposure	Category 1 (nervous system)		Danger	H370: Causes damage to organs (nervous system)	P307+P311: IF exposed: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ...	It was considered as Category 1(nerve systems) based on the description (Agricultural Chemical Registration Data ) that in mice and rats at the dose within the range of guidance value in Category 1 (more than 64mg/kg), entire body shivering, salivation, proneness position accompanied by dacryorrhea and a clonic convulsion, respiration depressed, protrusion of eyeballs, corneal reflex fall, and bloody tears were observed.
9	Specific target organ toxicity - Repeated exposure	Classification not possible	-	-	-	-	Since in mouse test, NOAEL=47.1-62.7 mg/kg is in the guidance value range of Category 2 (10-100 mg/kg), and although there is a description that toxic symptoms, such as decreased weight gain and accompanied decrease of organ weight, tranquility, piloerection and eyelid ptosis are observed in 162-222 mg/kg outside the range (Agricultural Chemical Registration Data), it cannot be classified only according to these data.
10	Aspiration hazard	Classification not possible	-	-	-	-	No data available

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
11	Hazardous to the aquatic environment （Acute）	Category 1		Warning	H400: Very toxic to aquatic life	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	It was classified into Category 1 from 48-hour EC50=0.0099 mg/L of Crustacea (Daphnia magna) (Agricultural Chemical Registration Data, 2004).
11	Hazardous to the aquatic environment （Long-term）	Category 1		Warning	H410: Very toxic to aquatic life with long lasting effects	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	Classified into Category 1, since acute toxicity was Category 1, and supposed not rapidly degrading (BIOWIN), though supposed less bioaccumulative (BCF=90 (Agricultural Chemical Registration Data, 1989))).